Cravatt Reagent
- CAS No.
- 1438416-21-7
- Chemical Name:
- Cravatt Reagent
- Synonyms
- KT195;KT109;HT-01;KT172;MJN110;Cravatt Reagent;MJN110 >=98% (HPLC);BEADRWVIFHOSGN-UHFFFAOYSA-N;MAGL,MJN 110,Inhibitor,Monoacylglycerol lipase,MJN110,MJN-110,inhibit;2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate
- CBNumber:
- CB02750604
- Molecular Formula:
- C22H21Cl2N3O4
- Molecular Weight:
- 462.33
- MDL Number:
- MFCD26960823
- MOL File:
- 1438416-21-7.mol
- MSDS File:
- SDS
Cravatt Reagent price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0872 | MJN110 ≥98% (HPLC) | 1438416-21-7 | 5mg | $120 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0872 | MJN110 ≥98% (HPLC) | 1438416-21-7 | 25mg | $194.8 | 2024-03-01 | Buy |
| Cayman Chemical | 17583 | MJN110 ≥95% | 1438416-21-7 | 5mg | $82 | 2024-03-01 | Buy |
| Cayman Chemical | 17583 | MJN110 ≥95% | 1438416-21-7 | 100mg | $808 | 2024-03-01 | Buy |
| Cayman Chemical | 17583 | MJN110 ≥95% | 1438416-21-7 | 1mg | $25 | 2021-12-16 | Buy |
Cravatt Reagent Chemical Properties,Uses,Production
Uses
Endocannabinoids such as 2-arachidonoyl glycerol (2-AG; ) and arachidonoyl ethanolamide (AEA; ) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. MJN110 is an N-hydroxysuccinimidyl carbamate that inhibits MAGL (IC50 = 9.1 nM) and to a lesser extent ABHD6 with potent selectivity over FAAH (IC50 > 10 μM) and other brain serine hydrolases. It can inhibit 2-AG hydrolysis (IC50 = 2.1 nM) with no effect on AEA hydrolysis up to 50 μM. At 5 mg/kg, MJN110 has been shown to alleviate mechanical allodynia in a rat model of diabetic neuropathy.[Cayman Chemical]
Uses
MJN110 has been used as a monoacylglycerol lipase (MAGL) inhibitor to study its effect on aggressive grooming in rats. It has also been used to inhibit lipid droplet formation.
Biochem/physiol Actions
MJN110 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) with >10,000 selectivity over FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA). MJN110 inhibits rat, mouse and human MAGL with IC50 values ranging from < 100 nM in rat to an IC50 of ~1 nM with 10- and 100-fold selectivity over closely related ABHD6, a serine hydrolase that acts as an alternative hydrolase of 2-AG, and LYPLA1/2 in human PC3 cells. MJN110 showed potent anti-hyperalgesic activity in a rat model of diabetic neuropathy, showing a therapeutic potential for treating diabetes chronic pain.
Cravatt Reagent Preparation Products And Raw materials
Raw materials
Preparation Products
Cravatt Reagent Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9374 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Yu Ben Biotechnology Co., Ltd. | 15502154572 | yuben012@sina.com | China | 505 | 58 |