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2-Oxetanone

2-Oxetanone
2-Oxetanone structure
CAS No.
57-57-8
Chemical Name:
2-Oxetanone
Synonyms
Betaprone;NSC-21626;Oxetanone;Propanlide;OXETANONE-2;Propanilide;Propanolide;2-OXETANONE;2-Oxooxetane;Oxetan-2-one
CBNumber:
CB0275433
Molecular Formula:
C3H4O2
Formula Weight:
72.06
MOL File:
57-57-8.mol

2-Oxetanone Properties

Melting point:
−33 °C(lit.)
Boiling point:
162 °C(lit.)
Density 
1.146 g/mL at 25 °C(lit.)
vapor pressure 
3 at 25 °C (NIOSH, 1997)
refractive index 
n20/D 1.412(lit.)
Flash point:
158 °F
storage temp. 
2-8°C
solubility 
Miscible with acetone, alcohol, chloroform, and ether (Windholz et al., 1983)
form 
Liquid
color 
Colorless liquid with a sweet but irritating odor
Water Solubility 
37 g/100 mL
Sensitive 
Moisture Sensitive
Merck 
14,7820
Henry's Law Constant
7.6 at 25 °C (approximate - calculated from water solubility and vapor pressure)
InChIKey
VEZXCJBBBCKRPI-UHFFFAOYSA-N
Indirect Additives used in Food Contact Substances
PROPIOLACTONE
FDA 21 CFR
175.105
CAS DataBase Reference
57-57-8(CAS DataBase Reference)
EWG's Food Scores
5
FDA UNII
6RC3ZT4HB0
NIST Chemistry Reference
«beta»-Propiolactone(57-57-8)
Proposition 65 List
beta-Propiolactone
EPA Substance Registry System
beta-Propiolactone (57-57-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H315-H319-H330-H350-H227
Precautionary statements  P210e-P304+P340-P320-P405-P501a-P201-P260-P284-P305+P351+P338-P310
Hazard Codes  T+
Risk Statements  45-26-36/38
Safety Statements  53-45-99
RIDADR  UN 3382 6.1/PG 1
WGK Germany  3
RTECS  RQ7350000
TSCA  Yes
HazardClass  6.1
PackingGroup  I
HS Code  29322090
Toxicity LC50 (inhalation) for rats 25 ppm/6-h (quoted, RTECS, 1985).
NFPA 704
2
0 0

2-Oxetanone price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P5648 β-Propiolactone Grade II, ≥90% 57-57-8 1ml $81.9 2019-12-02 Buy
Sigma-Aldrich P5648 β-Propiolactone Grade II, ≥90% 57-57-8 5ml $156 2019-12-02 Buy
Alfa Aesar B23197 beta-Propiolactone, 97% 57-57-8 5g $143 2020-06-24 Buy
Alfa Aesar B23197 beta-Propiolactone, 97% 57-57-8 1g $58 2020-06-24 Buy
Sigma-Aldrich P5648 β-Propiolactone Grade II, ≥90% 57-57-8 50ml $1080 2019-12-02 Buy

2-Oxetanone Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liqui

Chemical Properties

β-Propiolactone is a colorless liquid which slowly hydrolyzes to hydracrylic acid and must be cooled to remain stable.

Uses

Reacts with bacteriphage DNA causing inactivation, repair and recombination

Uses

antiandrogen

Uses

Versatile intermediate in organic synthesis.

brand name

Betaprone (Forest).

General Description

A colorless liquid with a slightly sweetish, pungent odor. Used as an intermediate in organic synthesis; disinfectant, sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments.

Air & Water Reactions

Slow reaction with water to form beta- hydroxypropionic acid.

Reactivity Profile

2-Oxetanone is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. 2-Oxetanone may be incompatible with alkalis.

Hazard

Strong skin and upper respiratory tract irri- tant, skin cancer. Possible carcinogen. Worker expo- sure should be minimized.

Health Hazard

The toxicity potential of 2-Oxetanone via inhalation or ingestion is high; may cause death or permanent injury after very short exposures to small quantities. It is a carcinogen.

Fire Hazard

Containers may explode. When heated to decomposition, 2-Oxetanone emits acrid smoke and fumes. Stable when stored at 41F. Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard. Tends to polymerize on storage. Avoid elevated temperatures.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by inhalation. Moderately toxic by intraperitoneal route. An initiator. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

β-Propiolactone is used as a chemical intermediate in synthesis of acrylic acid and esters, acrylate plastics; as a vapor sterilizing agent; phase disinfectant; and a viricidal agent.

Carcinogenicity

β-Propiolactone is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Chemical/Physical. Slowly hydrolyzes to hydracrylic acid (Windholz et al., 1983). In a reactor heated to 250 °C and a pressure of 12 mmHg, β-propiolactone decomposed to give equal amounts of ethylene and carbon dioxide (James and Wellington, 1969).

Shipping

UN3382 Toxic by inhalation liquid, n.o.s. with an LC 50 ≤1000 mL/m 3 and saturated vapor concentration ≥10 LC 50 , Hazard class: 6.1; Labels: 6.1 Technical Name Required, Inhalation Hazard Zone B. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Fractionally distil the lactone from sodium under reduced pressure. It gives an acidic solution in H2O. It irritates the skin and is a possib

Incompatibilities

Reacts with water, causing decomposi- tion and forming 3-hydroxypropionic acid (CAS: 503-66- 3), an irritant. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Incompatible with acet- ates, halogens, thiocyanates, thiosulfates, strong oxidizers; strong bases. Forms explosive mixture with air above 75℃. May polymerize upon storage or due to warming. Stable if kept under refrigeration @ 5 to 10 ℃/40 to 50 ℃.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

2-Oxetanone Preparation Products And Raw materials

Raw materials

Preparation Products


2-Oxetanone Suppliers

Global( 116)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21837 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
+8613111626072 zzwenxi@126.com CHINA 7497 58
Shijiazhuang Suking Biotechnology Co .,Ltd. Co., Ltd.
18732196011
18732196011 sales2@sxbiology.com CHINA 307 58
Zhengzhou Alfa Chemical Co.,Ltd
+86 13343822234
sales5@alfachem.cn;sales9@alfachem.cn;sale1@alfachem.cn CHINA 9751 58
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32444 55

View Lastest Price from 2-Oxetanone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-29 β-propiolactone
57-57-8
US $100.00 / g/Bag 100g/Bag Above 99% 20ton/month Shijiazhuang Suking Biotechnology Co .,Ltd. Co., Ltd.
2020-04-26 2-Oxetanone
57-57-8
US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
2019-07-10 2-Oxetanone
57-57-8
US $1.00 / KG 1KG 98% 1kg,5kg,100kg career henan chemical co

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