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5-PAHSA

CAS No.
1481636-41-2
Chemical Name:
5-PAHSA
Synonyms
5-PAHSA;QBGKCWKQYJQHJX-UHFFFAOYSA-N;Octadecanoic acid, 5-[(1-oxohexadecyl)oxy]-
CBNumber:
CB02756121
Molecular Formula:
C34H66O4
Molecular Weight:
538.89
MDL Number:
MOL File:
1481636-41-2.mol
Last updated:2024-07-02 08:54:57

5-PAHSA Properties

storage temp. -20°C
solubility DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H302-H315-H319-H331-H336-H351-H361d-H372-H412
Precautionary statements  P201-P273-P301+P312+P330-P302+P352-P304+P340+P311-P308+P313

5-PAHSA price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17043 5-PAHSA ≥95% 1481636-41-2 1mg $49 2024-03-01 Buy
Cayman Chemical 17043 5-PAHSA ≥95% 1481636-41-2 5mg $202 2024-03-01 Buy
Cayman Chemical 17043 5-PAHSA ≥95% 1481636-41-2 10mg $380 2024-03-01 Buy
TRC P133850 5-PAHSA 1481636-41-2 10mg $230 2021-12-16 Buy
TRC P133850 5-PAHSA 1481636-41-2 1mg $65 2021-12-16 Buy
Product number Packaging Price Buy
17043 1mg $49 Buy
17043 5mg $202 Buy
17043 10mg $380 Buy
P133850 10mg $230 Buy
P133850 1mg $65 Buy

5-PAHSA Chemical Properties,Uses,Production

Uses

5-PAHSA is used in biological studies for the discovery of a class of endogeneous mammalian lipids with anti-diabetic and anti-inflammatory effects.

Uses

Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. 5-PAHSA is a FAHFA in which palmitic acid is esterified at the 5th carbon of hydroxy stearic acid. PAHSA isoforms are the most abundant forms of FAHFA identified in the adipose tissue of glucose tolerant AG4OX mice. PAHSAs are synthesized in vivo in both mice and humans and are regulated by fasting and high-fat feeding in mice. PAHSA levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. PAHSA administration lowers ambient glycemia, improves glucose tolerance, and stimulates GLP-1 and insulin secretion in mice.[Cayman Chemical]

Definition

ChEBI: 5-PAHSA is a FAHFA obtained by formal condensation of the carboxy group of palmitic acid with the hydroxy group of 5-hydroxystearic acid. It has a role as a human metabolite, an anti-inflammatory agent and a hypoglycemic agent. It is a FAHFA and a long-chain fatty acid. It is functionally related to a hexadecanoic acid and an octadecanoic acid. It is a conjugate acid of a 5-PAHSA(1-).

General Description

Palmitic acid and hydroxystearic acid (PAHSA) containing (O-acyl)-hydroxy fatty acids are being found in tissues and serum extracts of mouse and human.

Biochem/physiol Actions

Palmitic acid and hydroxystearic acid (PAHSA) levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. In adipocytes, PAHSAs signal through G-protein-coupled receptor 120 (GPR120) to enhance insulin-stimulated glucose uptake. PAHSAs are fatty acid esters of hydroxy fatty acids (FAHFAs), which are endogenous lipids with the potential to treat diabetes and inflammation.

5-PAHSA Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 25)Suppliers
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Creative Enzymes
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Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44843 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
Shanghai Universal Biotech Co.,Ltd 18768175414 gaojun@univ-bio.com China 24998 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8732 58
SHANGHAI ZZBIO CO., LTD. 15102117276 19921389125 tech@zzbioco.com China 12064 58
5-PAHSA QBGKCWKQYJQHJX-UHFFFAOYSA-N Octadecanoic acid, 5-[(1-oxohexadecyl)oxy]- 1481636-41-2