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6-methoxy-1-tetralone

6-methoxy-1-tetralone Structure
6-methoxy-1-tetralone structure
CAS No.
1078-19-9
Chemical Name:
6-methoxy-1-tetralone
Synonyms
6-Methoxy-3,4-dihydronaphthalen-1(2H)-one;6-METHOXY-1-TETRALONE;1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-6-METHOXY-;6-Methoxy;6-METHOXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;6-Methoxy-3,4-dihydro-1(2H)-naphthalenone;6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE;6-Methoxy-tetalone;6-Methoxy-1-tetraL;6-METHOXY TETRALONE
CBNumber:
CB0277174
Molecular Formula:
C11H12O2
Molecular Weight:
176.21
MDL Number:
MFCD00001695
MOL File:
1078-19-9.mol
MSDS File:
SDS
Last updated:2023-11-03 14:55:47
Request For Quotation

6-methoxy-1-tetralone Properties

Melting point 77-79 °C (lit.)
Boiling point 171 °C/11 mmHg (lit.)
Density 1.0558 (rough estimate)
refractive index 1.5250 (estimate)
Flash point 171°C/11mm
storage temp. Sealed in dry,Room Temperature
form Fine Crystalline Powder
color Yellow to light brown
PH 5.96 at 23℃ and 10g/L
Merck 14,6000
BRN 972739
InChIKey MNALUTYMBUBKNX-UHFFFAOYSA-N
CAS DataBase Reference 1078-19-9(CAS DataBase Reference)
FDA UNII IA52U30635
NIST Chemistry Reference 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy-(1078-19-9)
EPA Substance Registry System 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy- (1078-19-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P261-P284-P301+P312+P330-P304+P340-P342+P311
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-20/21/22
Safety Statements  24/25-36-26
WGK Germany  3
Hazard Note  Irritant
TSCA  Yes
HS Code  29145000
NFPA 704
0
0 0

6-methoxy-1-tetralone price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M25589 6-Methoxy-1-tetralone 99% 1078-19-9 25g $36.66 2024-03-01 Buy
Sigma-Aldrich M25589 6-Methoxy-1-tetralone 99% 1078-19-9 100g $99.5 2024-03-01 Buy
TCI Chemical M0787 6-Methoxy-1-tetralone >99.0%(GC) 1078-19-9 25g $55 2024-03-01 Buy
TCI Chemical M0787 6-Methoxy-1-tetralone >99.0%(GC) 1078-19-9 250g $318 2024-03-01 Buy
Alfa Aesar A15967 6-Methoxy-1-tetralone, 99% 1078-19-9 5g $18.65 2024-03-01 Buy
Product number Packaging Price Buy
M25589 25g $36.66 Buy
M25589 100g $99.5 Buy
M0787 25g $55 Buy
M0787 250g $318 Buy
A15967 5g $18.65 Buy

6-methoxy-1-tetralone Chemical Properties,Uses,Production

Chemical Properties

yellow to light brown fine crystalline powder

Uses

6-Methoxy-1-tetralone is a reagent useful in the synthesis of (2-(furanyl)vinyl)-1-tetralone chalcones which possesses anticancer agents and inducers of apoptosis.

Definition

ChEBI: 6-Methoxy-1-tetralone is a member of tetralins.

Preparation

(1) Reacting anisole with an acylating agent in Lewis acid and a solvent at the temperature of-10-40 ℃ to generate an intermediate 1, wherein the molar ratio of the Lewis acid to the acylating agent to the anisole is 1-10: 1-10: 1, the Lewis acid is selected from one or more of concentrated sulfuric acid, phosphoric acid, polyphosphoric acid, zinc chloride, aluminum trichloride, superacid and heteropoly acid;
(2) the intermediate 1 does not need to be separated, the temperature is raised to 70-120 ℃, and the intermediate 1 continues to react to generate 6-methoxy-1-tetralone;
(3) cooling the reaction product, adding water to stop the reaction, extracting, purifying and desolventizing to obtain a crude product of the 6-methoxy-1-tetralone, and refining the crude product by a solvent to obtain a high-purity product.

Synthesis Reference(s)

Journal of the American Chemical Society, 64, p. 94, 1942 DOI: 10.1021/ja01253a025
Tetrahedron Letters, 9, p. 2917, 1968 DOI: 10.1016/S0040-4039(00)89611-2

Synthesis

The synthesis of 6-methoxy-1-tetralone is as follows:Eaton's reagent (1.00 mL, 5.31 mmol) was added slowly to a stirred solution of methyl 4-(3-methoxyphenyl)butanoate (4; 0.37g, 1.78 mmol) in DCE (1 mL). The resulting mixture was stirred at 75 °C for 2h under N2 atmosphere. Then, the reaction mixture was allowed to reach room temperature, and was poured over ice-water and extracted with EtOAc (3 × 15 mL). The combined organic extracts were washed successively with brine (2 × 15 mL) and H2O (2 × 20 mL), filtered over Na2SO4 and concentrated under reduced pressure. The resulting brownish oil was fractionated by column chromatography (silica gel, EtOAc-hexanes, 1:9) to obtain 6-methoxy-1-tetralone as ayellowish oil; yield: 0.28 g (91%).    1078-19-9.png

6-methoxy-1-tetralone synthesis

16821-32-2
1078-19-9
Synthesis of 6-methoxy-1-tetralone from 6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL

6-methoxy-1-tetralone Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID 6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALENE Detergent

Preparation Products

17-Ethinyl-3,17-dihydroxy-18-methylestra-2,5(10)-diene3-methylether 3-Methoxy-18-methylestra-1,3,5(10),8-tetraen-17-ethylene ketal 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal 3-Methoxy-18-methylestra-2,5(10)dien-17-one 17-ethylene ketal 6-CYANO-1-TETRALONE
6-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one 4-Methoxyphthalic acid 2-Methoxy-6,7,8,9-tetrahydrobenzocyclohepten-5-one 2-[2-(6-methoxytetralin-1-ylidene)-ethyl]-2-methylcyclopentane-1,3-dione 1-CHLORO-6-METHOXY-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE
7-METHOXY-4,5-DIHYDRO-NAPHTHO[1,2-D]THIAZOL-2-YLAMINE

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6-methoxy-1-tetralone Suppliers

Global( 418)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Triumpharm Co.,Ltd
+86-02586182925 +86-15105172550 info@triumpharm.com China 129 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12453 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 6992 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2966 58
Supplier Advantage
Nanjing Triumpharm Co.,Ltd
58
Hebei Mojin Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Jinan Finer Chemical Co., Ltd 		58

View Lastest Price from 6-methoxy-1-tetralone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-methoxy-1-tetralone pictures 2023-08-16 6-methoxy-1-tetralone
1078-19-9
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
6-methoxy-1-tetralone pictures 2023-04-26 6-methoxy-1-tetralone
1078-19-9
 US $30.00-10.00 / kg 10kg 99% 100000kg Hebei Guanlang Biotechnology Co,.LTD
6-methoxy-1-tetralone pictures 2023-02-23 6-methoxy-1-tetralone
1078-19-9
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD

6-methoxy-1-tetralone Spectrum

6-Methoxytetralone(1078-19-9)1HNMR6-Methoxytetralone(1078-19-9)IR16-Methoxytetralone(1078-19-9)IR26-Methoxytetralone(1078-19-9)Raman

1078-19-9(6-methoxy-1-tetralone)Related Search:

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6-METHOXY-1,2,3,4-TETRAHYDRO-1-NAPHTHALENONE 6-METHOXY-1,2,3,4-TETRAHYDRO-1-NAPHTHONE 6-METHOXY TETRALONE 6-METHOXY-ALPHA-TETRALONE TIMTEC-BB SBB007549 6-Methoxy-1,2,3,4-tetrahydro-1-naphthalenone for synthesis 3,4-dihydro-6-methoxy-1(2h)-naphthalenon 3,4-Dihydro-6-methoxy-1(2H)-napthalenone 6-Methoxy-tetalone 6-Methoxytetralin-1-one 3,4-Dihydro-6-methoxynaphthalen-1(2H)-one 98% 6-Methoxy-1-tetralone, 99% 25GR 6-METHOXY-1,2,3,4-TETRAHYDRO-1-NAPHTHALE METHOXY(6-)-1-TETRALONE 3,4-DIHYDRO-6-METHOXY-1(2H)-NAPHTHALENONE 6-Metoxy-1-tetralone 6-Methoxy-1-Tetralon 6-METHOXYA-TETRALONE 6-Methoxy-l-tetralone 1,2,3,4-Tetrahydro-6-methoxy-1-naphthalenone 1-Oxo-1,2,3,4-tetrahydro-6-methoxynaphthalene 6-Methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene 3,4-Dihydro-6-methoxynaphthalen-1(2H)-one 6-Methoxy-1-tetraL Levonorgestrel Impurity 13 Levonorgestrel Impurity 13 (6-Methoxy-1-tetralone) 6-Methoxy-1-tetralone> 6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE 6-METHOXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE 6-METHOXY-1-TETRALONE 6-Methoxy-3,4-dihydro-1(2H)-naphthalenone 1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-6-METHOXY- 6-Methoxy 6-Methoxy-3,4-dihydronaphthalen-1(2H)-one 1078-19-9 1078-19-1 KETONE Building Blocks C11 to C12 Carbonyl Compounds Organic Building Blocks Ketones Ketone C11 to C12 Carbonyl Compounds Ketones Carbonyl Compounds