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Moclobemide

Moclobemide
Moclobemide structure
CAS No.
71320-77-9
Chemical Name:
Moclobemide
Synonyms
Manefix;CS-1682;manerix;aurorix;Moclaime;Moclamine;MODOBEMDE;Moclamide;ro11-1163;moclbemide
CBNumber:
CB0281564
Molecular Formula:
C13H17ClN2O2
Formula Weight:
268.74
MOL File:
71320-77-9.mol

Moclobemide Properties

Melting point:
137°C
Boiling point:
447.7±40.0 °C(Predicted)
Density 
1.206±0.06 g/cm3(Predicted)
storage temp. 
Room temp
solubility 
DMSO: >20mg/mL
pka
14.26±0.46(Predicted)
form 
solid
color 
white
Merck 
14,6226
CAS DataBase Reference
71320-77-9(CAS DataBase Reference)
FDA UNII
PJ0Y7AZB63
NIST Chemistry Reference
Moclobemide(71320-77-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xn,T+
Risk Statements  22-37/38-41-26/27/28
Safety Statements  26-39-45-36/37/39-22
RIDADR  3249
WGK Germany  2
RTECS  CV2462000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29349990
Toxicity LD50 in rats (mg/kg): 707 orally (Burkard, Wyss)

Moclobemide price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M3071 Moclobemide ≥98% (HPLC), solid 71320-77-9 10mg $149 2021-03-22 Buy
Sigma-Aldrich M3071 Moclobemide ≥98% (HPLC), solid 71320-77-9 50mg $592 2021-03-22 Buy
TCI Chemical M2733 Moclobemide >98.0%(HPLC) 71320-77-9 10mg $122 2021-03-22 Buy
Cayman Chemical 24361 Moclobemide ≥98% 71320-77-9 1mg $35 2021-03-22 Buy
Cayman Chemical 24361 Moclobemide ≥98% 71320-77-9 5mg $88 2021-03-22 Buy

Moclobemide Chemical Properties,Uses,Production

Description

Moclobemide is the first of a new generation of non-hydrazine, reversible MAO-A inhibitors useful in the treatment of depression. Moclobemide is a selective inhibitor of MAO-A, allowing tyramine to be metabolized by MAO-B. In controlled studies, moclobemide was clinically superior to desipramine and showed no cholinergic or cardiovascular side-effects. A metabolite is currently under investigation for treatment of Parkinson’s disease,.

Chemical Properties

White to Off-White Solid

Originator

Hoffmann-LaRoche (Switzerland)

Uses

A reversible monoamine oxidase inhibitor

Uses

Antidepressant;Mono amine oxidase inhibitor (Type A)

Definition

ChEBI: A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.

brand name

Aurorix

Mechanism of action

Moclobemide is an RIMA that preferentially inhibits MAO-A (~80%) and, to a lesser extent, MAO-B (20–30% inhibition), thereby increasing the concentration of 5-HT, NE, and other catecholamines in the synaptic cleft and in storage sites. During chronic therapy with the MAOIs, adaptive changes at the noradrenergic and serotonergic receptors occur (“downregulation”) as a result of neurotransmitter hypersensitivity because of prolonged concentrations of NE and 5-HT at the postsynaptic receptor. This mechanism is likely the basis for its antidepressant activity. Inhibition of MAO-A by moclobemide is short-acting (maximum, 24 hours) and reversible. This is in contrast to phenelzine, which is nonselective, long-acting, and irreversible in its binding to MAO-A and MAO-B.
The pharmacokinetics for moclobemide are linear only up to 200 mg; at higher doses, nonlinear pharmacokinetics are observed. Although well absorbed from the GI tract, the presence of food reduces the rate but not the extent of absorption of moclobemide. Small quantities of moclobemide are distributed into human breast milk. Moclobemide undergoes a complex metabolism, initially involving morpholine carbon and nitrogen oxidation, deamination, and aromatic hydroxylation. The N-oxide and ring-opened metabolites retain some in vitro MAO-A inhibition. Moclobemide is a weak inhibitor of CYP2D6 in vitro. It is extensively metabolized in the liver by oxidation and is eliminated primarily into the urine as conjugates. Less than 1% of an administered dose of moclobemide is eliminated unmetabolized.
Because moclobemide is partially metabolized by the polymorphic isozymes CYP2C19 and CYP2D6, plasma concentrations of moclobenmide may be affected in patients who are poor metabolizers. In patients who are slow metabolizers, the AUC for moclobemide was 1.5 times greater than the AUC in patients who are extensive metabolizers and receiving the same dose. This increase is within the normal range of variation (up to twofold) typically seen in patients.

Drug interactions

Drug interactions for the RIMAs include interaction with SSRI antidepressants, which can cause the 5-HT syndrome. The effect of stimulant drugs, such as methylphenidate and dextroamphetamine (used to treat ADHD), may be increased. Some over-the-counter cold and hay fever decongestants (i.e., sympathomimetic amines) can have increased stimulant effects. Selegiline, a selective MAO-B used for Parkinson's disease, should not be used concurrently with the RIMAs. Unlike the irreversible MAOIs, no significant interactions with foods occur, because the selective inhibition of MAO-A does not stop the metabolism of tyramine. The RIMAs must not be taken concurrently with a nonreversible MAOI.

Moclobemide Preparation Products And Raw materials

Raw materials

Preparation Products


Moclobemide Suppliers

Global( 211)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8875 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26711 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29983 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
BOC Sciences
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1-631-614-7828 inquiry@bocsci.com United States 19843 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37041 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47494 58

View Lastest Price from Moclobemide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-11 Moclobemide
71320-77-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09 Moclobemide
71320-77-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-06-26 Moclobemide
71320-77-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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