ChemicalBook >> CAS DataBase List >>BOC-D-4,4'-BIPHENYLALANINE

BOC-D-4,4'-BIPHENYLALANINE

BOC-D-4,4'-BIPHENYLALANINE structure

CAS No.: 128779-47-5

Chemical Name:: BOC-D-4,4'-BIPHENYLALANINE

Synonyms: BOC-D-4;impurity 43;BOC-D-BPH-OH;BOC-D-BIP-OH;-BIPHENYLALANINE;BOC-D-BIP(4,4')-OH;SACUBITRIL(LCZ696);BOC-D-4,4'-BIPHE-OH;LCZ-696 Impurity 80;BOC-4-BIPHENYL-D-ALA

CBNumber:: CB0285209

Molecular Formula:: C20H23NO4

Molecular Weight:: 341.4

MDL Number:: MFCD00191185

MOL File:: 128779-47-5.mol

Last updated:2025-08-08 17:45:00

Product description	Number	Pack Size	Price
Boc-D-4,4''-biphenylalanine	B642900	1g	$95
[1,1'-Biphenyl]-4-propanoicacid,α-[[(1,1-dimethylethoxy)carbonyl]amino]-,(αR)- 99.43%	CS-W023100	10g	$113
Boc-D-4,4'-Biphenylalanine	V1221	1g	$77
Boc-D-4,4-Biphenylalanine 95+%	074852	5g	$125
Boc-D-4,4-Biphenylalanine 95+% ee	AS32716	5G	$131
More product size

Request For Quotation

BOC-D-4,4'-BIPHENYLALANINE Properties

Boiling point	528.2±50.0 °C(Predicted)
Density	1.161±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	3.88±0.10(Predicted)
form	Solid
Appearance	White to off-white Solid
CAS DataBase Reference	128779-47-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

Hazard Codes

HS Code

2922498590

NFPA 704

	1
0		0

BOC-D-4,4'-BIPHENYLALANINE price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B642900	Boc-D-4,4''-biphenylalanine	128779-47-5	1g	$95	2021-12-16	Buy
ChemScene	CS-W023100	[1,1'-Biphenyl]-4-propanoicacid,α-[[(1,1-dimethylethoxy)carbonyl]amino]-,(αR)- 99.43%	128779-47-5	10g	$113	2021-12-16	Buy
AK Scientific	V1221	Boc-D-4,4'-Biphenylalanine	128779-47-5	1g	$77	2021-12-16	Buy
Matrix Scientific	074852	Boc-D-4,4-Biphenylalanine 95+%	128779-47-5	5g	$125	2021-12-16	Buy
Activate Scientific	AS32716	Boc-D-4,4-Biphenylalanine 95+% ee	128779-47-5	5G	$131	2021-12-16	Buy

Product number	Packaging	Price	Buy
B642900	1g	$95	Buy
CS-W023100	10g	$113	Buy
V1221	1g	$77	Buy
074852	5g	$125	Buy
AS32716	5G	$131	Buy

BOC-D-4,4'-BIPHENYLALANINE Chemical Properties,Uses,Production

Uses

Boc-D-4,4'-biphenylalanine is used as a reagent in the synthesis of pyrrolopyrimidine inhibitors of Akt as antitumor agents. Boc-D-4,4'-biphenylalanine is also used in the preparation of (-)-Bestatin-based inhibitors.

Synthesis

24424-99-5

155760-02-4

3-BIPHENYL-4-YL-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID

119273-61-9

To a mixed solution of tetrahydrofuran (THF) (80 mL) and water (80 mL) of (S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid (25) (5 g, 20.72 mmol) was added di-tert-butyl dicarbonate (BOC2O) (5.77 mL, 24.87 mmol) and sodium hydroxide (NaOH) (1.077 g. 26.9 mmol). The reaction mixture was stirred at room temperature for 6 hours before being cooled to 0 °C and the pH was adjusted to about 6-7 by slowly adding 1.5 N aqueous hydrochloric acid (HCl) to quench the reaction. Subsequently, the reaction mixture was extracted with ethyl acetate (EtOAc) (3 x 50 mL). The combined organic layers were washed sequentially with brine (50 mL) and water (50 mL), dried over anhydrous sodium sulfate and concentrated to give the crude product as a colloidal off-white solid. The crude product was purified by washing with petroleum ether (PE) with 10% ethyl acetate (4 x 20 mL). The resulting white solid was filtered and dried under vacuum to afford (S)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propionic acid (26) (6.5 g, 19.04 mmol, 92% yield). The product was analyzed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI) to confirm the structure.1H NMR data: δ 7.67-7.62 (m, 2H), 7.58 (d, J=8.5 Hz, 2H), 7.50-7.43 (m, 2H), 7.39-7.31 (m, 3H), 7.10 (d, J=8.0 Hz. 1H), 4.17-4.07 (m, 1H), 3.07 (dd, J=13.6,4.5Hz, 1H), 2.88 (dd, J=13.6,10.0Hz, 1H), 1.37-1.23 (m, 9H). Mass spectral data: 340.2 ([M-1]-).

References

[1] Tetrahedron Letters, 2018, p. 4267 - 4271

BOC-D-4,4'-BIPHENYLALANINE Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate N-Boc-4-broMo-L-phenylalanine Methyl ester Phenylboronic acid L-4,4'-BIPHENYLALANINE Sodium hydroxide

Tetrahydrofuran Water

1of2

Preparation Products

sacubitril (2S,4S)-Sacubitril-O-isobutane LCZ696 InteMediate [1,?1'-?Biphenyl]?-?4-?pentanoic acid, γ-?[[4-?(1,?1-?dimethylethoxy)?-?1,?4-?dioxobutyl]?amino]?-?α-?methyl-?, ethyl ester, [S-?(R*,?S*)?]?- (9CI)

BOC-D-4,4'-BIPHENYLALANINE Suppliers

Global( 156)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29833	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	19881	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15082	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58

Supplier	Advantage
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Standardpharm Co. Ltd.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nextpeptide Inc	58

View Lastest Price from BOC-D-4,4'-BIPHENYLALANINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-12	BOC-D-4,4"-BIPHENYLALANINE 128779-47-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	BOC-D-4,4'-BIPHENYLALANINE 128779-47-5	US $7.00 / kg	1kg	99%	100kg	Career Henan Chemical Co
2019-07-06	BOC-D-4,4'-BIPHENYLALANINE 128779-47-5	US $7.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

BOC-D-4,4"-BIPHENYLALANINE
128779-47-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

BOC-D-4,4'-BIPHENYLALANINE
128779-47-5
US $7.00 / kg
99%
Career Henan Chemical Co

BOC-D-4,4'-BIPHENYLALANINE
128779-47-5
US $7.00 / KG
99%
Career Henan Chemical Co

BOC-D-4,4'-BIPHENYLALANINE Spectrum

BOC-D-4,4'-BIPHENYLALANINE(128779-47-5)¹HNMR

128779-47-5(BOC-D-4,4'-BIPHENYLALANINE)Related Search:

Telmisartan Impurity 10 1426129-50-1 enantioMer (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester N-NITROSO-DI-ISO-PROPYLAMINE

LCZ-696 Impurity 60 Valsartan Impurity 32 (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate Valsartan Impurity 1 [1,1'-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, (Hydrochloride)(1:1), (αS,γS)-

4-(2-Cyanophenyl)benzyl alcohol Valsartan n-Propyl Valsartan Desvaleryl Impurity Isoleucine Valsartan USAWIVMZUYOXCF-UHFFFAOYSA-N

Valsartan Ethyl Ester Valsartan Impurity 3 Valsartan Impurity 61

1of4

BOC-D-PHE(4-PHENYL)-OH BOC-D-BPH-OH BOC-D-BIP(4,4')-OH BOC-D-BIP-OH BOC-D-ALA(4,4'-BIPHENYL)-OH BOC-3-(4-BIPHENYLYL)-D-ALANINE BOC-4-PHENYL-D-PHENYLALANINE BOC-4-PHENYL-D-PHE-OH BOC-4-BIPHENYL-D-ALA BOC-BETA-(4-BIPHENYLYL)-D-ALA-OH BOC-P-PHENYL-D-PHE-OH BOC-(R)-2-AMINO-3-(1,1'-BIPHENY-4-YL)PROPANOIC ACID D-TBOC-P-BIPHENYLALANINE (R)-3-BIPHENYL-4-YL-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID Boc-D-4-Phenylphenylalanine N-ALPHA-T-BUTOXYCARBONYL-D-4,4'-BIPHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-D-(4-PHENYL)PHENYLALANINE (R)-N-ALPHA-TERT-BUTYLOXYCARBONYL-BIPHENYLALANINE N-Boc-3-(4-biphenylyl)-D-alanine, 95% (2R)-3-(Biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid (2R)-3-(Biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propionic acid, tert-Butyl [(1R)-2-(biphenyl-4-yl)-1-carboxyethyl]carbamate (R)-a-(Boc-amino)-biphenyl-4-propanoic acid N-Boc-3-(4-biphenylyl)-D-alani (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoic acid Boc-p-phenyl-D-Phenylalanine≥ 99% (HPLC) 4-Phenyl-D-phenylalanine, N-BOC protected (R)-3-(biphenyl-4-yl)-2-(tert-butoxycarbonylamino)propanoic acid (R)-N-ALPHA-T-BUTYLOXYCARBONYL-BIPHENYLALANINE 3-(4-Biphenylyl)-N-(tert-butoxycarbonyl)-D-alanine REF DUPL: Boc-D-4,4'-Biphenylalanine (S)-2-AMino-3-(4'-((S)-2-(tert-butoxycarbonylaMino)-2-carboxyethyl)biphenyl-4-yl)propanoic acid Boc-b-(4-biphenylyl)-D-Ala-OH, Boc-D-Bip-OH BOC-D-4,4'-BIPHE-OH (R)-3-([1,1\'-biphenyl]-4-yl)-2-aminopropanoic acid hydrochloride [1,1'-Biphenyl]-4-propanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αR)- (Tert-Butoxy)Carbonyl D-4,4'-Biphenylalanine Sacubitril Impurity 55 SACUBITRIL(LCZ696) -BIPHENYLALANINE (2R)-3-{[1,1'-biphenyl]-4-yl}-2-{[(tert-butoxy)carbonyl]amino}propanoic acid impurity 43 N-Boc-3-(4-biphenylyl)-D-alanine,95% (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoicaci BOC-D-4,4'-BIPHENYLALANINE USP/EP/BP BOC-D-4 LCZ-696 Impurity 80 Boc-d-4,4'-biphenylalanine (R)-3-([1,1'-Biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid LCZ696 valsartan + sacubitril impurity 43 N-Boc-3-(4-biphenylyl)-D-alanine 128779-47-5 C20H23NO4 Phenylalanine analogs and other aromatic alpha amino acids Amino Acids a-amino Biphenyl & Diphenyl ether Amino Acid Derivatives