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N-(3-Trifluoromethylphenyl)piperazine

N-(3-Trifluoromethylphenyl)piperazine Structure
N-(3-Trifluoromethylphenyl)piperazine structure
CAS No.
15532-75-9
Chemical Name:
N-(3-Trifluoromethylphenyl)piperazine
Synonyms
TFTP;AKOS BBS-00003586;RARECHEM AH CK 0203;LABOTEST-BB LT00044462;1-(3-Methoxyphenyl)pipera;Flibanserin Impurity 2 Monomer;1-(3-TRIFLUOROMETHYL)-PIPERAZINE;3-(1-piperazino)benzotrifluoride;1-(3-Trifloromethyphenyl)piperazin;N-(3-TRIFLUOROMETHYLPHENYL)PIPERAZINE
CBNumber:
CB0286059
Molecular Formula:
C11H13F3N2
Molecular Weight:
230.23
MDL Number:
MFCD00005959
MOL File:
15532-75-9.mol
Last updated:2023-05-15 10:43:32

N-(3-Trifluoromethylphenyl)piperazine Properties

Boiling point 100-102°C 0,1mm
Density 1.226 g/mL at 25 °C(lit.)
refractive index n20/D 1.521(lit.)
Flash point >230 °F
storage temp. -20°C
pka 8.88±0.10(Predicted)
Sensitive Air Sensitive
BRN 614217
CAS DataBase Reference 15532-75-9(CAS DataBase Reference)
FDA UNII 25R3ONU51C
NIST Chemistry Reference Piperazine, 1-[3-(trifluoromethyl)phenyl]-(15532-75-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370-H314-H318
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a-P210-P260-P280-P301+P310-P311
Hazard Codes  Xi,C
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  2735
WGK Germany  3
RTECS  TM2820000
Hazard Note  Corrosive
HazardClass  8
PackingGroup  II
HS Code  29335995
NFPA 704
1
2 0

N-(3-Trifluoromethylphenyl)piperazine Chemical Properties,Uses,Production

Chemical Properties

clear colourless to yellow slightly viscous liquid

Uses

1-[3-(Trifluoromethyl)phenyl]piperazine is used in preparation of (Piperazinylethyl)cyclohexanamide derivatives and used as treatment or prevention of D3 and/or 5HT-2 receptor diseases.

Definition

ChEBI: A N-arylpiperazine that is piperazine substituted by a 3-(trifluoromethyl)phenyl group at position 1. A serotonergic agonist used as a recreational drug.

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 319, 1996 DOI: 10.1016/0040-4039(95)02162-0

N-(3-Trifluoromethylphenyl)piperazine synthesis

110-85-0
401-78-5
15532-75-9
Synthesis of N-(3-Trifluoromethylphenyl)piperazine from Piperazine and 3-Bromobenzotrifluoride

N-(3-Trifluoromethylphenyl)piperazine Preparation Products And Raw materials

Raw materials

Diethylene glycol monomethyl ether Silica gel Hexane Benzyltriethylammonium chloride 2-Diethylaminoethylchloride hydrochloride
Diethyl ether Ethyl acetate Bis(2-chloroethyl)amine hydrochloride Methanol Sodium hydroxide
3-Aminobenzotrifluoride Sodium carbonate 3-Chlorobenzotrifluoride Piperazine 3-Bromobenzotrifluoride

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Preparation Products

N-(3-Trifluoromethylphenyl)piperazine Spectrum

N-(3-Trifluoromethylphenyl)piperazine(15532-75-9)MSN-(3-Trifluoromethylphenyl)piperazine(15532-75-9)1HNMRN-(3-Trifluoromethylphenyl)piperazine(15532-75-9)13CNMRN-(3-Trifluoromethylphenyl)piperazine(15532-75-9)IR1N-(3-Trifluoromethylphenyl)piperazine(15532-75-9)Raman

15532-75-9(N-(3-Trifluoromethylphenyl)piperazine)Related Search:

Lithium trifluoromethanesulfonate Benzotrifluoride Trifluoromethanesulfonic acid Diphenyl ether Dichloromethylphenylsilane
Methyltriphenylphosphonium bromide 1-Methylpiperazine (Trifluoromethyl)trimethylsilane 1,2-Dimethylhydrazine Dihydrochloride Piperazine
4-Aminobenzotrifluoride 1-BENZHYDRYLPIPERAZINE PHENYL VALERATE PHENYL RESIN 1-(4-CHLORO-3-TRIFLUOROMETHYLPHENYL)PIPERAZINE
1-(3-Trifluoromethylphenyl)piperazine hydrochloride N-(3-Trifluoromethylphenyl)piperazine 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE

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LABOTEST-BB LT00044462 3-(PIPERAZIN-1-YL)TRIFLUOROMETHYLBENZENE 3-(TRIFLUOROMETHYL)-N-PHENYLPIPERAZINE AKOS BBS-00003586 1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLYL)PIPERAZINE 1-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE 1-(3-TRIFLUOROMETHYL)-PIPERAZINE RARECHEM AH CK 0203 N-(ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLYL)PIPERAZINE N-(A,A,A-TRIFLUORO-M-TOLYL)PIPERAZINE N-(3-TRIFLUOROMETHYLPHENYL)PIPERAZINE 1-(α,α,α-Trifluoro-m-tolyl)piperazine 3-(1-Piperazino)benzotrifluoride~N-(alpha,alpha,alpha-Trifluoro-m-tolyl)piperazine N-(alpha,alpha,alpha-trifluoro-3-tolyl)piperazine 3-(1-piperazino)benzotrifluoride n-(à,à,à-trifluoro-m-tolyl)piperazine 1-[3-(Trifluoromethyl)phenyl]piperazine 97% 1-[3-(Trifluoromethyl)phenyl]piperazine97% N-(alpha,alpha,alpha-Trifluoro-m-tolyl)piperazine 1-(3-Trifluoromethyl)phenylpiperazine N-(3-Trifluoromethylphenyl)piperazine 1-(3-Trifloromethyphenyl)piperazin 1-(3-TRIFLUOROMETHYL)PHENYLPIPERAZINE 98+% 1-(A,A,A-TRI-FLUORO-M-TOLYL)-PIPERAZINE Piperazine, 1-[3-(trifluoromethyl)phenyl]- 1-[m-(Trifluoromethyl)phenyl]piperazine TFTP N-(alpha,alpha,alpha-Trifluoro-m-tolyl)piperazine,98% 1-[3-(Trifluoromethyl)phenyl]piperazine ,99% 3-(TRIFLUOROMETHYL)-N-PHENYLPIPERAZINE F 3-TRIFLUOROMETHYLPHENYLPIPERAZINE Hydrochloride D4 Flibanserin Impurity 2 Monomer 1-(3-Methoxyphenyl)pipera 15532-75-9 AMINE TP - TZ Analytical Chromatography Product Catalog Alphabetic Analytical Standards Piperazines pharmacetical Piperidines, Piperidones, Piperazines