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Tranilast

Tranilast
Tranilast structure
CAS No.
53902-12-8
Chemical Name:
Tranilast
Synonyms
n-5’;MK 341;TraniL;rizaben;Tranpro;SB-252218;TRANILAST;Tranilast USP/EP/BP;Tranilast(SB 252218);Rizaben,MK 341,Tranpro
CBNumber:
CB0289227
Molecular Formula:
C18H17NO5
Formula Weight:
327.33
MOL File:
53902-12-8.mol

Tranilast Properties

Melting point:
166.2-168.2 °C (lit.)
Boiling point:
465.23°C (rough estimate)
Density 
1.3185 (rough estimate)
refractive index 
1.5100 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: 18 mg/mL
form 
powder
pka
3.47±0.36(Predicted)
color 
white to beige
Merck 
14,9570
InChIKey
NZHGWWWHIYHZNX-CSKARUKUSA-N
CAS DataBase Reference
53902-12-8(CAS DataBase Reference)
FDA UNII
HVF50SMY6E
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Hazard Codes  Xn
Risk Statements  22
Safety Statements  26-36
WGK Germany  3
RTECS  DG8731000
Toxicity LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385)

Tranilast price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 616400-M Tranilast 53902-12-8 10mg-m $147 2020-08-18 Buy
Sigma-Aldrich 616400-M Tranilast - CAS 53902-12-8 - Calbiochem An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. 53902-12-8 10 mg $147 2021-03-22 Buy
Sigma-Aldrich T0318 Tranilast ≥98% (HPLC), powder 53902-12-8 10mg $159 2021-03-22 Buy
TCI Chemical T2935 Tranilast >98.0%(HPLC)(T) 53902-12-8 1g $141 2021-03-22 Buy
TCI Chemical T2935 Tranilast >98.0%(HPLC)(T) 53902-12-8 5g $484 2021-03-22 Buy

Tranilast Chemical Properties,Uses,Production

Chemical Properties

Pale Green Solid

Originator

Rizaben,Kissei Pharmaceutical Co., Ltd.,Japan,1982

Uses

Antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.

Uses

coronary vasodilator

Uses

Tranilast is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. Tranilast suppresses production of prostaglandin D2 (IC50 = 0.1 mM), prostaglandin E2 (IC50 = ~1-20 μM), thromboxane B2 (IC50 = ~10-50 μM), TGF-β1 (IC50 = ~100-200 μM), and interleukin-8 (IC50 = ~100 μM) in in vitro models as well as attenuates of the proinflammatory activity of human monocytes. While originally marketed as an antiallergenic drug, the efficacy of tranilast in preventing restenosis after percutaneous coronary intervention has been tested in a large-scale clinical trial. Additionally, tranilast inhibits VEGF-induced angiogenetic activities (i.e., proliferation, migration and tube formation of vascular endothelial cells) with IC50 values of 22, 18 and 193 μM, which may prove therapeutic for various retinal diseases.[Cayman Chemical]

Definition

ChEBI: An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.

Manufacturing Process

4 g of 3,4-dimethoxycinnamic acid was dissolved in 20 ml of dry pyridine. To this solution were added under cooling with ice and agitation 2 g of benzenesulfonyl chloride whereby a red orange precipitate was formed. The reaction mixture was stirred for about one hour and then 2 g of methyl anthranilate were added to the mixture under cooling with ice. The mixture was stirred for 2 hours at room temperature to complete the reaction. After completion of the reaction, the reaction mixture was concentrated and the residue was taken up in about 10 ml of chloroform. The solution was washed first with a 10% aqueous solution of caustic soda, then with a 10% aqueous solution of hydrochloric acid and finally with water and then distilled to remove chloroform whereby crystals of N-(3',4'-dimethoxycinnamoyl)- anthranilic acid methyl ester were obtained.
This product was dissolved in 10 ml of chloroform. To this solution were added 10 ml of a 10% aqueous solution of caustic soda and the mixture was warmed at 50°C to effect hydrolysis of the ester group. After completion of the reaction, the organic phase was separated, washed with water and distilled to remove the solvent whereby 2.1 g (yield: 48%) of the end product, i.e., N- (3',4'-dimethoxycinnamoyl)-anthranilic acid, were obtained. This product had a melting point of 211°C to 213°C

Therapeutic Function

Antiallergic

Biological Activity

Antiallergic via inhibition of chemical mediator release from mast cells. Most recently shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT 1 receptor.

Tranilast Preparation Products And Raw materials

Raw materials

Preparation Products


Tranilast Suppliers

Global( 234)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5450 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
86-021-61999440
contact@trustwe.com CHINA 9885 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17607 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58

View Lastest Price from Tranilast manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-29 Tranilast
53902-12-8
US $1.00 / g 1g ≥97.0% 10kg/month WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-13 Tranilast
53902-12-8
US $8.89 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2021-07-20 Tranilast
53902-12-8
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd

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