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Tranilast

Tranilast
Tranilast structure
CAS No.
53902-12-8
Chemical Name:
Tranilast
Synonyms
n-5’;MK 341;rizaben;Tranpro;SB-252218;TRANILAST;Tranilast(SB 252218);Rizaben,MK 341,Tranpro;Nano Liposomal Tranilast;Tranilast - CAS 53902-12-8 - Calbiochem
CBNumber:
CB0289227
Molecular Formula:
C18H17NO5
Formula Weight:
327.33
MOL File:
53902-12-8.mol

Tranilast Properties

Melting point:
166.2-168.2 °C(lit.)
Boiling point:
465.23°C (rough estimate)
Density 
1.3185 (rough estimate)
refractive index 
1.5100 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: 18 mg/mL
pka
3.47±0.36(Predicted)
form 
powder
color 
white to beige
Merck 
14,9570
InChIKey
NZHGWWWHIYHZNX-CSKARUKUSA-N
CAS DataBase Reference
53902-12-8(CAS DataBase Reference)
FDA UNII
HVF50SMY6E
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Hazard Codes  Xn
Risk Statements  22
Safety Statements  26-36
WGK Germany  3
RTECS  DG8731000
Toxicity LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385)

Tranilast price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 616400-M Tranilast 53902-12-8 10mg-m $141 2019-12-02 Buy
Sigma-Aldrich T0318 Tranilast ≥98% (HPLC), powder 53902-12-8 10mg $147 2019-12-02 Buy
TCI Chemical T2935 Tranilast >98.0%(HPLC)(T) 53902-12-8 1g $136 2019-12-02 Buy
TCI Chemical T2935 Tranilast >98.0%(HPLC)(T) 53902-12-8 5g $467 2019-12-02 Buy
Cayman Chemical 13044 Tranilast ≥98% 53902-12-8 5mg $15 2018-11-13 Buy

Tranilast Chemical Properties,Uses,Production

Chemical Properties

Pale Green Solid

Uses

coronary vasodilator

Uses

Tranilast is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. Tranilast suppresses production of prostaglandin D2 (IC50 = 0.1 mM), prostaglandin E2 (IC50 = ~1-20 μM), thromboxane B2 (IC50 = ~10-50 μM), TGF-β1 (IC50 = ~100-200 μM), and interleukin-8 (IC50 = ~100 μM) in in vitro models as well as attenuates of the proinflammatory activity of human monocytes. While originally marketed as an antiallergenic drug, the efficacy of tranilast in preventing restenosis after percutaneous coronary intervention has been tested in a large-scale clinical trial. Additionally, tranilast inhibits VEGF-induced angiogenetic activities (i.e., proliferation, migration and tube formation of vascular endothelial cells) with IC50 values of 22, 18 and 193 μM, which may prove therapeutic for various retinal diseases.[Cayman Chemical]

Uses

Antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.

Definition

ChEBI: An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.

Biological Activity

Antiallergic via inhibition of chemical mediator release from mast cells. Most recently shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT 1 receptor.

Tranilast Preparation Products And Raw materials

Raw materials

Preparation Products


Tranilast Suppliers

Global( 177)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30052 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 14164 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35438 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 20537 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47484 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
+8613111626072 zzwenxi@126.com CHINA 7497 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132152 58
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32445 55
MedicalChem(Yancheng)Manuf.Co.,Ltd +86-515-84383180
+86-515-84383182 sales@medicalchem.com China 80 69

View Lastest Price from Tranilast manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-21 Tranilast
53902-12-8
US $1.00 / kg 1g 99% 100KG career henan chemical co

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