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ZANAMIVIR HYDRATE

ZANAMIVIR HYDRATE
ZANAMIVIR HYDRATE
CAS No.
139110-80-8
Chemical Name:
ZANAMIVIR HYDRATE
Synonyms
GANA;GG 167;Relenza;Zanamir;Zanamivir;Hsdb 7437;GR 121167X;Unii-L6o3xi777i;GANA (inhibitor);ZANAMIVIR HYDRATE
CBNumber:
CB0292498
Molecular Formula:
C12H20N4O7
Formula Weight:
332.31
MOL File:
139110-80-8.mol

ZANAMIVIR HYDRATE Properties

Melting point:
2560C (dec.)
alpha 
D20 +40.9° (c = 0.9 in water)
storage temp. 
-20°C Freezer
solubility 
H2O: soluble10mg/mL, clear
form 
powder
color 
white to beige
optical activity
[α]/D +30 to +40°, c = 1 in H2O
InChIKey
ARAIBEBZBOPLMB-UFGQHTETSA-N
CAS DataBase Reference
139110-80-8
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  3
RTECS  RA9451000
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

ZANAMIVIR HYDRATE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0492 Zanamivir ≥98% (HPLC) 139110-80-8 10mg $98.8 2018-11-20 Buy
Sigma-Aldrich 1724088 Zanamivir United States Pharmacopeia (USP) Reference Standard 139110-80-8 200mg $482.65 2018-11-13 Buy
Cayman Chemical 15123 Zanamivir ≥98% 139110-80-8 1mg $26 2018-11-13 Buy
Cayman Chemical 15123 Zanamivir ≥98% 139110-80-8 5mg $46 2018-11-13 Buy
Sigma-Aldrich Y0001708 Zanamivir for system suitability European Pharmacopoeia (EP) Reference Standard 139110-80-8 y0001708 $179 2018-11-23 Buy

ZANAMIVIR HYDRATE Chemical Properties,Uses,Production

Chemical Properties

Colorless Crystalline Solid

Uses

Influenza viral neuraminidase inhibitor; structural analog of the sialic acid. Antiviral

Uses

antineoplastic, anti-metabolite

Uses

Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles. It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50 values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50 values ranging from 0.6 to 7.9 nM in vitro. Intranasal zanamivir administration at 0.4 mg/kg twice daily can reduce mortality and viral titers in lung homogenates of mice infected with influenza. The efficacy and tolerabilbity of zanamivir has also been established in clinical trial.[Cayman Chemical]

brand name

Relenza (GlaxoSmithKline).

Acquired resistance

Resistance is presently uncommon, including strains resistant to oseltamivir. In clinical trials the frequency was no more than 1% of exposed patients.

Pharmaceutical Applications

A synthetic neuraminidase inhibitor formulated for administration by inhalation.

Pharmacokinetics

Oral bioavailability is poor. After inhalation local respiratory mucosal concentrations greatly exceed those that are inhibitory for influenza A and B replication. The median concentrations in the sputum exceed 1 mg/L 6 h after inhalation and remain detectable for 24 h.

Clinical Use

Treatment of influenza A and B infections in patients over 7 years of age, and prophylaxis of patients ??5 years of age

Side effects

Most adverse effects are related to the respiratory tree. These include rhinorrhea and, rarely, bronchospasm. Nausea and vomiting have been reported at low incidence.

ZANAMIVIR HYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products


ZANAMIVIR HYDRATE Suppliers

Global( 154)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 955 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19990 58
Jinan Rouse Industry Co., Ltd. 86-(0)531-82929600 18615510361
86-(0)531-82921652 sale@rousechem.com China 113 58
Suizhou Jiake Biological Engineering Co., Ltd. 0722-3632989;18008664499;0722-3632789;18008664168
0722-3255139 QQ:2286801987;2549463910 2286801987@qq.com China 95 58
Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2928 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6054 61

View Lastest Price from ZANAMIVIR HYDRATE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 ZANAMIVIR HYDRATE
139110-80-8
US $2.00 / kg 1kg 99% 100kg career henan chemical co

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