VERRUCULOGEN
- CAS No.
- 12771-72-1
- Chemical Name:
- VERRUCULOGEN
- Synonyms
- tr1;T1R1;TRXR1;GPR70;TAS1R1;NA 209A;GRIM-12;MGC9145;TR-1TOXIN;VERRUCOLOGEN
- CBNumber:
- CB0294003
- Molecular Formula:
- C27H33N3O7
- Molecular Weight:
- 511.57
- MDL Number:
- MFCD00079645
- MOL File:
- 12771-72-1.mol
- MSDS File:
- SDS
| Boiling point | 738.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.49±0.1 g/cm3(Predicted) |
| Flash point | 2℃ |
| storage temp. | 2-8°C |
| solubility | Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide |
| form | buffered aqueous solution |
| pka | 10?+-.0.70(Predicted) |
| color | White to off-white |
| FDA UNII | S1P1U6VVZ8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302+H312+H332-H319 | |||||||||
| Precautionary statements | P210-P261-P280-P305+P351+P338-P370+P378-P403+P235 | |||||||||
| Hazard Codes | T,Xn,F | |||||||||
| Risk Statements | 23/24/25-36-20/21/22-11 | |||||||||
| Safety Statements | 36/37/39-45-36/37-26-16 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | JH4920000 | |||||||||
| HS Code | 38220090 | |||||||||
| NFPA 704 |
|
VERRUCULOGEN price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB1304378 | ANTI-TAS1R1 (CENTER) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 12771-72-1 | 400μL | $461 | 2023-01-07 | Buy |
| Cayman Chemical | 11351 | Verruculogen ≥95% | 12771-72-1 | 1mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 11351 | Verruculogen ≥95% | 12771-72-1 | 5mg | $300 | 2024-03-01 | Buy |
| Usbiological | V2121-71 | Verruculogen | 12771-72-1 | 1mg | $368 | 2021-12-16 | Buy |
| Usbiological | 226788 | Verruculogen | 12771-72-1 | 1mg | $389 | 2021-12-16 | Buy |
VERRUCULOGEN Chemical Properties,Uses,Production
Uses
Verruculogen is a tremorgenic mycotoxin, first isolated from Penicillium verruculosum in 1972. The structure was resolved as an indole alkaloid in 1974. Verruculogen is produced by several species of Penicillium and Aspergillus and its presence is a useful taxonomic phenotypic marker. The tremorgenic action of verruculogen is associated with increases in spontaneous glutamate and aspartate release, decreases in GABA levels and, at toxic doses, an increase in the number and decrease in the affinity of DHP receptors in rat cortex. In in vitro guinea pig ileum preparations, verruculogen causes an increase in contractile responses due to electrical field stimulation, attributed to enhancement of acetylcholine from presynaptic nerve terminals. Verruculogen also inhibits Ca2+-activated K+ channels, and is a cell cycle inhibitor blocking division at the M phase.
Uses
Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Uses
Verruculogen is a tremorgenic mycotoxin isolated from species of Penicillium, Aspergillus, and other fungi. It selectively inhibits the activation of Maxi-K potassium channels by charybdotoxin with a K1/2 value of 170 nM. Verruculogen also promotes the release of excitatory neurotransmitters when injected directly into the brain of rats and, at high doses, arrests mouse mammary carcinoma cells in M phase of the cell cycle (MIC = 12.2 μM).[Cayman Chemical]
Definition
ChEBI: An organic heterohexacyclic compound that is a mycotoxic indole alkaloid isolated from Penicillium and Aspergillus species.
Biological Activity
verruculogen is a maxi-k potassium channels inhibitor.maxi-k, a potassium channel characterized by their large conductance for potassium ions through cell membranes, is activated by changes in membrane electrical potential and/or by increases in concentration of intracellular calcium ion. maxi-k channels are critical for the regulation of several key physiological processes, such as smooth muscle tone and neuronal excitability.
Biochem/physiol Actions
The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]
in vitro
in a previous study, it was found that aflatrem, paspalitrem a, paspalitrem c, penitrem a, and paspalinine could inhibit the binding of [125i]charybdotoxin to maxi-k channels in bovine aortic smooth muscle sarcolemmal membranes. whereas, verruculogen enhanced toxin binding. despite their different effects on binding of [125i]charybdotoxin to maxi-k channels, all tested compounds including verruculogen were able to potently inhibit maxi-k channels in electrophysiological experiments, and other types of voltage-dependent or ca(2+)-activated k+ channels examined were not affected [1].
in vivo
in an animal study, the mechanism of the genesis of tremor induced by verruculogen was investigated. it was found that atropine, glycine, mephenesin, and penicillamine with proven efficacy in relieving tremor of varied etiology, failed to modify verruculogen induced tremor. oxyaminoacetic acid, which raises the cns levels of gaba, and beta (chlorphenyl) gamma aminobutyric acid, which passes the hematoencephalic barrier, completely or partly relieved tremor and other verruculogen-induced symptoms, depending on the dose of the verruculogen administered. picrotoxin, a gaba antagonist, increased the effect of verruculogen in the tested animals [2].
storage
+4°C
References
[1] knaus, h. g.,mcmanus, o.b.,lee, s.h., et al. tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. biochemistry 33(19), 5819-5828 (1994).
[2] hotujac l, stern p. pharmacological examination of verruculogen induced tremor. acta med iugosl. 1974;28(3):223-9.
VERRUCULOGEN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11442 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4515 | 55 |
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