CC-115
- CAS No.
- 1228013-15-7
- Chemical Name:
- CC-115
- Synonyms
- CC-115;CS-2038;CC-115, >95%;CC115;CC 115;CC-115(free base);DNA-dependent protein kinase,inhibit,CC115,CC-115,DNA-PK,mTOR,Inhibitor,Mammalian target of Rapamycin;1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one;1-Ethyl-7-(2-methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one;Pyrazino[2,3-b]pyrazin-2(1H)-one, 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-
- CBNumber:
- CB03041392
- Molecular Formula:
- C16H16N8O
- Molecular Weight:
- 336.35
- MDL Number:
- MFCD29036965
- MOL File:
- 1228013-15-7.mol
| Boiling point | 587.3±60.0 °C(Predicted) |
|---|---|
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥50 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| form | solid |
| pka | 5.94±0.20(Predicted) |
| FDA UNII | FII75TFH5L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
CC-115 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19420 | CC-115 ≥95% | 1228013-15-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19420 | CC-115 ≥95% | 1228013-15-7 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 19420 | CC-115 ≥95% | 1228013-15-7 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 19420 | CC-115 ≥95% | 1228013-15-7 | 25mg | $533 | 2024-03-01 | Buy |
| ChemScene | CS-4561 | CC-115 96.64% | 1228013-15-7 | 10mg | $150 | 2021-12-16 | Buy |
CC-115 Chemical Properties,Uses,Production
Biological Activity
cc-115 is a inhibitor of mtor/dna-pk.the mammalian target of rapamycin (mtor) kinase is a key mediator of the phosphoinositide 3-kinase /protein kinase b (akt pathway). the dna-dependent protein kinase (dna-pk) is a critical component of the dna repair machinery governings the response to dna damage, which serves to maintain genome integrity.
in vitro
previous study found that the proliferation induced by cd40(+) interleukin-21 stimulation could be completely blocked by cc-115, and cd40-mediated resistance to fludarabine and venetoclax could also be reverted by cc-115. moreover, bcr-mediated signaling was blocked by cc-115 and in cll samples from patients with acquired resistance to idelalisib treatment [1].
in vivo
preclinical studies showed that cc-115 had good in vivo pk profiles across multiple species with 53%, 76%, and around100% oral bioavailability in mouse, rat, and dog, respectively [2].
target
| Target | Value |
| DNA-PK (Cell-free assay) | 0.013 μM |
| mTOR (Cell-free assay) | 0.021 μM |
| PI3Kα (Cell-free assay) | 0.852 μM |
IC 50
21/ 13 nm for mtor/dna-pk
References
[1] thijssen r,et al. dual tork/dna-pk inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. blood.2016 jul 28;128(4):574-83.
[2] mortensen ds, et al. optimization of a series of triazole containing mammalian target of rapamycin (mtor) kinase inhibitors and the discovery of cc-115. j med chem. 2015 jul 23;58(14):5599-5608.
CC-115 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |
