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AMG 9810

AMG 9810 Structure
AMG 9810 structure
CAS No.
545395-94-6
Chemical Name:
AMG 9810
Synonyms
9810;CS-2548;AMG 9810;AMG 9810;AMG-9810;AMG 9810 >=98% (HPLC), powder;(2E)-N-(2，3-Dihydro-1，4-benzodi;3-[4-(TERT-BUTYL)PHENYL]-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ACRYLAMIDE;3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide;(2E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enamide;(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propanamide
CBNumber:
CB0306302
Molecular Formula:
C21H23NO3
Molecular Weight:
337.41
MDL Number:
MFCD00955103
MOL File:
545395-94-6.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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AMG 9810 Properties

Boiling point 512.5±50.0 °C(Predicted)
Density 1.175±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >5mg/mL
pka 12.22±0.20(Predicted)
form powder
color white to beige
FDA UNII 182HIJ2D7F

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H413
Precautionary statements  P264-P270-P273-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

AMG 9810 price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A2731 AMG 9810 ≥98% (HPLC), powder 545395-94-6 10mg $227 2024-03-01 Buy
Sigma-Aldrich A2731 AMG 9810 ≥98% (HPLC), powder 545395-94-6 50mg $357.6 2024-03-01 Buy
Alfa Aesar J64202 AMG 9810 545395-94-6 25mg $308 2023-06-20 Buy
Cayman Chemical 14715 AMG 9810 ≥98% 545395-94-6 5mg $57 2024-03-01 Buy
Cayman Chemical 14715 AMG 9810 ≥98% 545395-94-6 10mg $95 2024-03-01 Buy
Product number Packaging Price Buy
A2731 10mg $227 Buy
A2731 50mg $357.6 Buy
J64202 25mg $308 Buy
14715 5mg $57 Buy
14715 10mg $95 Buy

AMG 9810 Chemical Properties,Uses,Production

In vivo

AMG9810 is effective at preventing capsaicin-induced eye wiping in a dose-dependent manner, and it reverses thermal and mechanical hyperalgesia in a model of inflammatory pain induced by intraplantar injection of complete Freund's adjuvant. At effective doses, AMG9810 does not show any significant effects on motor function. AMG9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain. AMG9810, promotes mouse skin tumor development. The topical application of AMG9810 results in a significant increase in the expression level of the epidermal growth factor receptor (EGFR) and its downstream Akt/mammalian target of rapamycin (mTOR)-signaling pathway.

Description

AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat, respectively). Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC50s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. In a rat model of inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia.

Uses

AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat, respectively). Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC50s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. In a rat model of inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia.[Cayman Chemical]

Definition

ChEBI: 3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-propenamide is a member of cinnamamides and a secondary carboxamide.

Biological Activity

AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC 50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain.

Biochem/physiol Actions

AMG 9810?is the cinnamide TRPV1 (vanilloid receptor 1) antagonist, that can prevent eye wiping behavior, stimulated by capsaicin and can inverse hyperalgesia in an animal model of inflammatory pain. It possesses antihyperalgesic properties.

storage

+4°C (desiccate)

References

[1]. gavva nr, tamir r, qu y, et al. amg 9810 [(e)-3-(4-t-butylphenyl)-n-(2, 3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (trpv1) antagonist with antihyperalgesic properties. j pharmacol exp ther, 2005, 313(1):474-84.

AMG 9810 Preparation Products And Raw materials

Raw materials

Preparation Products

AMG 9810 Suppliers

Global( 81)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33349 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Hunan HuaTeng Pharmaceutical Co., Ltd., 400-8592883 15367835770 viola@huatengsci.com China 5877 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Chongqing Chemdad Co., Ltd 		58
career henan chemical co 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Hunan HuaTeng Pharmaceutical Co., Ltd., 58

View Lastest Price from AMG 9810 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2E)-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-PROPENAMIDE pictures 2020-01-14 (2E)-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-PROPENAMIDE
545395-94-6
 US $9.80 / KG 1g ≥99% 100kg Career Henan Chemical Co

AMG 9810 Spectrum

AMG 9810(545395-94-6)1HNMR

545395-94-6(AMG 9810)Related Search:

PSY-279 IBTU JYL-273 BCTC Acrylamide
(E)-N-(3-METHOXY-PHENYL)-3-PHENYL-ACRYLAMIDE AMG 9810 4-TERT-BUTYLSTYRENE 3-(4-TERT-BUTYL-PHENYL)-PROPENAL

1of2

3-[4-(TERT-BUTYL)PHENYL]-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ACRYLAMIDE AMG 9810 (2E)-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-PROPENAMIDE (2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propanamide 2-PropenaMide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-diMethylethyl)phenyl]-, (2E)- CS-2548 AMG 9810;AMG-9810 3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide 9810 AMG 9810 >=98% (HPLC), powder (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enamide Transient receptor potential channels,inhibit,Inhibitor,AMG-9810,AMG9810,AMG 9810,TRP Channel (2E)-N-(2，3-Dihydro-1，4-benzodi 545395-94-6 Vanilloid/TRPV channel