STING agonist-1
- CAS No.
- 702662-50-8
- Chemical Name:
- STING agonist-1
- Synonyms
- STING agonist-1;STING agonist-1 (G10);4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide;4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide;2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-;inhibit,TMEM173,Inhibitor,STING agonist 1,G 10,G-10,Stimulator of Interferon Genes,STING agonist-1,MITA,MPYS,Virus Protease,ERIS,STING agonist1,STING
- CBNumber:
- CB03067022
- Molecular Formula:
- C21H16ClFN2O3S
- Molecular Weight:
- 430.88
- MDL Number:
- MOL File:
- 702662-50-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
STING agonist-1 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22353 | G10 ≥98% | 702662-50-8 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 22353 | G10 ≥98% | 702662-50-8 | 5mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 22353 | G10 ≥98% | 702662-50-8 | 10mg | $164 | 2024-03-01 | Buy |
| Cayman Chemical | 22353 | G10 ≥98% | 702662-50-8 | 25mg | $438 | 2021-12-16 | Buy |
| TRC | G932043 | G10 | 702662-50-8 | 2.5mg | $165 | 2021-12-16 | Buy |
STING agonist-1 Chemical Properties,Uses,Production
Description
G10 is an indirect activator of stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
Uses
G10 is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV).
storage
Store at -20°C
STING agonist-1 Preparation Products And Raw materials
Raw materials
Preparation Products
STING agonist-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Tianjin Derchemist Science & Technology Co., Ltd. | 22-58627059 13920586291 | zdcomcon@126.com | China | 2918 | 50 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |