GSK-3326595
- CAS No.
- 1616392-22-3
- Chemical Name:
- GSK-3326595
- Synonyms
- GSK3326595;6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide;EPZ-015938;GSK-3326595,EPZ-015938;EPZ-015938 (GSK3326595);EPZ015938(pemrametostat);Pemrametostat (GSK3326595);EPZ015938; EPZ 015938; EPZ-015938;Pemrametostat, GSK3326595, EPZ015938;6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1
- CBNumber:
- CB03121890
- Molecular Formula:
- C24H32N6O3
- Molecular Weight:
- 452.55
- MDL Number:
- MFCD29991177
- MOL File:
- 1616392-22-3.mol
| Boiling point | 760.3±60.0 °C(Predicted) |
|---|---|
| Density | 1.275±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Soluble in DMSO (up to 20 mg/ml). |
| pka | 12.44±0.46(Predicted) |
| form | solid |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| FDA UNII | VXT8SZ6875 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
GSK-3326595 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27305 | GSK3326595 | 1616392-22-3 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 27305 | GSK3326595 | 1616392-22-3 | 25mg | $343 | 2024-03-01 | Buy |
| Cayman Chemical | 27305 | GSK3326595 | 1616392-22-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 27305 | GSK3326595 | 1616392-22-3 | 10mg | $199 | 2024-03-01 | Buy |
| ChemScene | CS-6451 | GSK3326595 99.55% | 1616392-22-3 | 50mg | $250 | 2021-12-16 | Buy |
GSK-3326595 Chemical Properties,Uses,Production
Description
GSK3326595 (1616395-22-3) is a potent (IC50?= 6.2nM), selective (>4000-fold over 20 other methyltransferases), SAM uncompetitive, peptide competitive inhibitor of PRMT5.1?PRMT5 inhibition activated the p53 pathway?via?induction of alternative splicing of MDM4 leading to a potent anti-proliferative response both?in vitro?and?in vivo. Combination therapy with palbociclib (CDK4/6 inhibitor, Focus Cat.# 10-4760) and GSK3326595 lead to increased efficacy of palbociclib in treating native and resistant models of melanoma via regulation of the PRMT5-MDM4 axis.2?Currently in clinical trials.3
Uses
GSK-3326595 is a protein arginine methyltransferase 5(PRMT5) inhibitor under clinical trial.
References
1) Gerhart?et al.?(2018),?Activation of the p53-MDM4 regulatory axis defines the anti-tumor response to PRMT5 inhibition through its role in regulating cellular splicing; Sci. Rep.?8?9711 2) AbuHammad?et al.?(2019),?Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma; Proc. Natl. Acad. Sci. USA?116?179909 3) NCT02783300
GSK-3326595 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-3326595 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1472 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Chengdu Henghui Pharm Tec Co. Ltd. | 13540674322 15828370308 | CHINA | 121 | 55 |