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Budesonide

Description indications Precaution and Inhibition References
Budesonide
Budesonide structure
CAS No.
51333-22-3
Chemical Name:
Budesonide
Synonyms
BIDIEN;S-1320;Budeson;Entocort;Micronyl;Respules;Barazone;PREFERID;SPIROCORT;PULMICORT
CBNumber:
CB0313122
Molecular Formula:
C25H34O6
Formula Weight:
430.53
MOL File:
51333-22-3.mol

Budesonide Properties

Melting point:
221-232°C (dec.)
Boiling point:
464.79°C (rough estimate)
alpha 
D25 +98.9° (c = 0.28 in methylene chloride)
Density 
1.1046 (rough estimate)
refractive index 
1.4593 (estimate)
storage temp. 
Store at RT
solubility 
Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
form 
powder
Merck 
14,1468
InChIKey
VOVIALXJUBGFJZ-KWVAZRHASA-N
CAS DataBase Reference
51333-22-3(CAS DataBase Reference)

SAFETY

Hazard Codes  Xn
Risk Statements  40-36/37/38-20/21/22
Safety Statements  22-36-26
WGK Germany  3
RTECS  TU3723000
HS Code  29372900

Budesonide price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B7777 Budesonide ≥99% 51333-22-3 250mg $202 2018-11-13 Buy
Sigma-Aldrich 1078201 Budesonide United States Pharmacopeia (USP) Reference Standard 51333-22-3 200mg $352.8 2018-11-20 Buy
Cayman Chemical 15407 Budesonide ≥95% 51333-22-3 50mg $35 2018-11-13 Buy
Cayman Chemical 15407 Budesonide ≥95% 51333-22-3 100mg $53 2018-11-13 Buy
Sigma-Aldrich PHR1178 Budesonide Pharmaceutical Secondary Standard; Certified Reference Material 51333-22-3 500mg $81.3 2018-11-20 Buy

Budesonide Chemical Properties,Uses,Production

Description

Budesonide (brand name: Pulmicort) is a synthetic corticosteroid medication. It is indicated for the maintenance and prophylactic treatment of asthma. It is also used for the long-term management of chronic obstructive pulmonary disease (COPD). It is also useful for the treatment of inflammatory bowel disease including Crohn’s disease, ulcerative colitis and microscopic colitis, and also for treating allergic rhinitis. It exhibits potent glucocorticoid activity and weak mineralocorticoid activity in vivo. It is effective in inhibiting the activities of multiple cell types and mediators participating in either allergic or non-allergic-mediated inflammation.

indications

Budesonide is a commonly used in the treatment of bronchial asthma clinical drug in China.it can be used for non-hormone-dependent or hormone-dependent asthma, and chronic asthmatic bronchitis. Or it is used for the treatment of seasonal allergic rhinitis and many years occurring allergic rhinitis and it is used for preventing polyps regeneration after the removal of nasal polyps . It can also be used to treat various skin diseases.
Budesonide is a halogen-free, topically applied , adrenal corticosteroid,it has significant anti-inflammatory, anti-allergic, anti-itching and anti-exudative effects. Its local effects is the same as beclomethasone dipropionate , it is mainly used for bronchial asthma which in the past bronchodilator or an antiallergic agent can not well control. This product can relieve bronchial spasm, pulmonary inhalation has anti-inflammatory effects, long-term use is well tolerated, it can reduce oral glucocorticoid dosage, without systemic effects of corticosteroids. It has the same effect on Children and adults with asthma as beclomethasone dipropionate , it has good effect, and it can be tolerated in long-term use ,for glucocorticoid-dependent or glucocorticoid-independent patients, mist inhaled can control asthma attacks and can effectively relapse prevention, inhaled treatment for 3 to 6 months, improvement in lung function is shown,the number of acute episodes is reduced , recoverability of plasma corticosterone concentration is gradually increased, and the daily dose of oral corticosteroids can be reduced by 40% to 50%. Thus,for glucocorticoid-dependent asthma patients, especially in patients with a larger amount of dose,the product can be used as an ideal alternative to thedrug for oral administration. Glucocorticoid effects of budesonide are strong, but mineralocorticoid effects are weak . Animal tests show that the drug’s effects on glucocorticoid receptor affinity are 200 times of cortisone, anti-inflammatory effects when it is applied topically are 1,000 times of cortisone , and subcutaneous and oral anti-inflammatory effects are only 40 and 25 times stronger than cortisone .

Precaution and Inhibition

Take Caution when it is used in tuberculosis, airway fungal infection or viral infection. Avoid pregnancy administration. Oral steroid-dependent patients, should gradually reduce oral steroid dose after 10d use , until it reaches a stable respiratory capacity minimum. In severe stress, the dose of oral steroids should be increased, such as severe infection, trauma, surgery. When sputum thickens and congests the airway , the short-term oral steroid should be supplemented . Fast Reduction of Oral hormone, can cause withdrawal symptoms, such as arthritis, rhinitis, eczema, muscle and joint pain,which should be paid attention to prevent it.
Budesonide can be used for mild asthma, when asthma symptoms are obvious,they should be added with a larger dose of water-soluble corticosteroids or bronchodilators and antihistamines. Aerosol has throat irritation on individual patient , Candida albicans infections may occur , rinse mouth and throat immediately after inhalation which can reduce irritation.
The above information is edited by the chemicalbook of Tian Ye.

References

http://www.rxlist.com/entocort-drug/indications-dosage.htm
https://en.wikipedia.org/wiki/Budesonide
https://www.drugbank.ca/drugs/DB01222

Chemical Properties

White Solid

Uses

A non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent

Uses

laxative, antineoplastic

Uses

The oral capsule is used for the treatment of mild to moderate active Crohn's disease. The oral tablet is used for induction of remission in patients with active, mild to moderate ulcerative colitis. The oral inhalation formulation is used for the treatme

Definition

ChEBI: A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.

Uses

Budesonide is a glucocorticoid steroid that activates the glucorcorticoid receptor with an EC50 value of 12.4 nM. Like other glucocorticoids, budesonide reduces inflammation and has utility in inflammatory diseases, like asthma and inflammatory bowel disease. Also like other glucocorticoids, budesonide may be abused by athletes.[Cayman Chemical]

brand name

Entocort (AstraZeneca); Pulmicort (AstraZeneca); Rhinocort (AstraZeneca).

General Description

Budesonide (Pulmicort Turbohaler,Rhinocort) is extensively metabolized in the liver, with 85%to 95% of the orally absorbed drug metabolized by the firstpasseffect. The major metabolites are 6β-hydroxybudesonideand 16α-hydroxyprednisolone, both with less than1% of the activity of the parent compound. Metabolism involvesthe CYP3A4 enzyme, so coadministration of budesonidewith a known CYP3A4 inhibitor should be monitoredcarefully.

General Description

Budesonide, 16α,17-[butylidenebis-(oxy)]-11β,21-dihydroxypregna-1,4-diene-3, 20-dione (Entocort), in oral capsules is used to treat Crohn disease. Theaffinity for the GC is approximately 200-fold greater than thatof hydrocortisone and 15-fold greater than that of prednisolone.Budesonide is a mixture of epimers, with the 22Rform having twice the affinity for the GR of the S epimer.This GC is metabolized by CYP3A4, and its levels can be increasedin the presence of potent CYP3A4 inhibitors.Budesonide is also used in an inhaled formulation for thetreatment of asthma.

Biological Activity

Synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. Reverses DNA hypomethylation and modulates expression of cancer related genes.

Budesonide Preparation Products And Raw materials

Raw materials

Preparation Products


Budesonide Suppliers

Global( 245)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 416 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 956 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8430 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 898 58

View Lastest Price from Budesonide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-18 Budesonide
51333-22-3
US $1.00 / kg 1kg 95%-99% 10kg career henan chemical co
2018-03-09 Budesonide
51333-22-3
US $100.00 / KG 10G 99%min 100kg/week Hubei XinRunde Chemical Co., Ltd.
2018-08-10 Budesonide
51333-22-3
US $10.00 / KG 1KG 99% 100 MT per month Hebei Guanlang Biotechnology Co., Ltd.

51333-22-3(Budesonide)Related Search:


  • BIDIEN
  • BUDESONIDE
  • CORTIVENT
  • ENTOCORT CR
  • 1,4-PREGNADIEN-(R, S)-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE CYCLIC 16,17 ACETAL
  • 16,17-BUTYLIDENEBIS[OXY]-11,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
  • (11-beta,16-alpha)-16,17-(butylidenebis(oxy))-11,21-dihydroxypregna-1,4-dien
  • 16-alpha)-et
  • PULMICORT
  • SPIROCORT
  • S-1320
  • RHINOCORT
  • 16alpha(R),17-[butylidenebis(oxy)]-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
  • Budesonide EP
  • Budsonide
  • S-1320, Bidien, Cortivent, Entocort CR, Preferid, Pulmicort, rhinocort, Spirocort,
  • Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11.beta.,16.alpha.)-
  • BUDESONIDE,MICRONIZED
  • BUDESONIDE,MICRONIZED,EP
  • 16α,17α-Butylidenedioxy-11β,21-dihydroxypregna-1,4-dien-3,20-dione
  • 16α,17α-(Butylidenedioxy)-11β,21-dihydroxypregna-1,4-diene-3,20-dione
  • 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv.
  • Entocort
  • Micronyl
  • Pregna-1,4-diene-3,20-dione, 16,17-[butylidenebis(oxy)]-11,21-dihydroxy-, (11β,16α)-
  • Pulmicort Turbuhaler
  • Respules
  • Rhinocort Aqua
  • 16a, 17a - Butylidenedioxy - 11, 21 - dihydroxy - 1, 4 - pregnadiene - 3, 20 - dione]
  • Pregna-1,4-diene-3,20-dione, 16,17-[butylidenebis(oxy)]-11,21-dihydroxy-, (11b,16a)-
  • 11β,21-Dihydroxy-16α,17-(butylidenebisoxy)pregna-1,4-diene-3,20-dione
  • 11β,21-Dihydroxy-16α,17-(butylidenedioxy)pregna-1,4-diene-3,20-dione
  • S-budesonide
  • (11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
  • Budesonide,16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
  • 17-alpha-butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-16-alph
  • 4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-pregna-(11-b
  • Budeson
  • NebuaMpul
  • Budesonide controlled-release
  • Barazone
  • Budecort Aqua
  • Pregna-1,4-diene-3,20-dione, 16,17-[(1R)-butylidenebis(oxy)]-11,21-dihydroxy-, (11β,16α)-
  • Budesonide solution,100ppm
  • Budesonide, >=99%
  • -
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • 51333-22-3
  • 1950-4-4
  • Immune Cell Signaling and Blood
  • Immune System Regulation
  • Immunomodulators and Antibiotics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • CASAKOL
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