Fenfluramine hydrochloride
- CAS No.
- 404-82-0
- Chemical Name:
- Fenfluramine hydrochloride
- Synonyms
- FENFLURAMINE HCL;ponderal;ponderax;FENFLURAMINE HYDROCHLORIDE;FEBFLURAMINE HYDROCHLORIDE;phenfluoraminehydrochloride;rac Fenfluramine Hydrochloride;2H6]-Fenfluramine hydrochloride;(+/-)-FENFLURAMINE HYDROCHLORIDE;Fenfluramine hydrochloride USP/EP/BP
- CBNumber:
- CB0314194
- Molecular Formula:
- C12H17ClF3N
- Molecular Weight:
- 267.72
- MDL Number:
- MFCD00058016
- MOL File:
- 404-82-0.mol
- MSDS File:
- SDS
| Melting point | 1660C |
|---|---|
| Boiling point | 108-112 °C(Press: 12 Torr) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly) |
| form | A solid |
| Stability | Hygroscopic |
| CAS DataBase Reference | 404-82-0(CAS DataBase Reference) |
| FDA UNII | 3KC089243P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45-36/37/39-22 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DA0295500 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | LD50 oral in rabbit: 50mg/kg | |||||||||
| NFPA 704 |
|
Fenfluramine hydrochloride price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22491 | 3-trifluoromethyl-N-Ethylamphetamine (hydrochloride) ≥98% | 404-82-0 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 22491 | 3-trifluoromethyl-N-Ethylamphetamine (hydrochloride) ≥98% | 404-82-0 | 5mg | $61 | 2024-03-01 | Buy |
| TRC | F245605 | DL-FenfluramineHydrochloride | 404-82-0 | 1g | $525 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002686 | FENFLURAMINE HYDROCHLORIDE 95.00% | 404-82-0 | 5MG | $950 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002686 | FENFLURAMINE HYDROCHLORIDE 95.00% | 404-82-0 | 50MG | $2500 | 2021-12-16 | Buy |
Fenfluramine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Controlled substance. Anorexic
Definition
ChEBI: The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
brand name
Pondimin (Robins).
General Description
Fenfluramine hydrochloride, (±)N-ethyl- -methyl-m-(trifluoromethyl)phenethylamine hydrochloride (Pondimin), isunique in this group of drugs, in that it tends to produce sedationrather than excitation. Effects are said to be mediatedprincipally by central serotoninergic, rather than central noradrenergic,mechanisms. In large doses in experimental animals,the drug is a serotonin neurotoxin.It was withdrawnfrom human use after reports of heart valve damage and pulmonaryhypertension. From its structure, more apolar or hydrophobiccharacter than amphetamine, tropism for serotoninergicneurons would be expected. Likewise, thestructure suggests an indirect mechanism. If an indirectmechanism were operative, then all postsynaptic 5-HT receptors could be activated. Evidence from several studies indicatesthat the 5-HT1B and the 5-HT2C receptors are mostresponsible for the satiety effects of 5-HT. 5-HT may alsoinfluence the type of food selected (e.g., lower-fat food intake).The(+) isomer, dexfenfluramine (Redux), has agreater tropism for 5-HT systems than the racemic mixture.It, too, was withdrawn because of toxicity.
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: mydriasis, change in motor activity, nausea. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl
Fenfluramine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29321 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Hangzhou Yuhao Chemical Technology Co., Ltd | 0571-82693216 | info@yuhaochemical.com | China | 9394 | 52 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4505 | 50 |
View Lastest Price from Fenfluramine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | Fenfluramine hydrochloride
404-82-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-08-04 | Fenfluramine hydrochloride USP/EP/BP
404-82-0
|
US $1.10 / g | 1g | 0.999 | 100 Tons min | Dideu Industries Group Limited |
-
- Fenfluramine hydrochloride
404-82-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Fenfluramine hydrochloride USP/EP/BP
404-82-0
- US $1.10 / g
- 0.999
- Dideu Industries Group Limited