LDN 193189 hydrochloride
- CAS No.
- 1435934-00-1
- Chemical Name:
- LDN 193189 hydrochloride
- Synonyms
- DM-3189 2HCl;LDN-193189 2HC;LDN-193189 2HCl;LDN-193189 (DM3189) 2HCl;LDN 193189 dihydrochloride;Viomycin LDN 193189 Dihydrochloride;4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
- CBNumber:
- CB03146321
- Molecular Formula:
- C25H24Cl2N6
- Molecular Weight:
- 479.40426
- MDL Number:
- MOL File:
- 1435934-00-1.mol
LDN 193189 hydrochloride price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) | 1435934-00-1 | 5mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) | 1435934-00-1 | 25mg | $219 | 2024-03-01 | Buy |
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) | 1435934-00-1 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) | 1435934-00-1 | 10mg | $100 | 2024-03-01 | Buy |
| Tocris | 6053 | LDN193189dihydrochloride ≥98%(HPLC) | 1435934-00-1 | 10 | $216 | 2021-12-16 | Buy |
LDN 193189 hydrochloride Chemical Properties,Uses,Production
Description
LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.
storage
-20°C
References
1) Yu?et al.?(2008),?BMP type 1 receptor inhibition reduces heterotropic ossification; Nature Med.,14?1363 2) Chambers?et al.?(2012),?Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors; Nature Biotechnol.?30?715 3) Kreitzer?et al. (2013)?A robust method to derive functional neural crest cells from human pluripotent stem cells; Am. J. Stem Cells,?2?119 4) Lee?et al.?(2011)?BMP4 promotes prostate tumor growth in bone through osteogenesis; Cancer Res.?71?5194
LDN 193189 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
LDN 193189 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | SALES@UHNSHANGHAI.COM | China | 977 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |