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MKC3946

MKC3946 structure

CAS No.: 1093119-54-0

Chemical Name:: MKC3946

Synonyms: MKC3946;MKC3946;MKC-3946;MKC 3946;Inositol requiring enzyme 1,inhibit,IRE1,MKC3946,Inhibitor,MKC 3946,MKC-3946;2-Hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde;1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-

CBNumber:: CB03155064

Molecular Formula:: C21H20N2O3S

Molecular Weight:: 380.46

MDL Number:

MOL File:: 1093119-54-0.mol

Last updated:2023-09-20 16:43:00

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MKC3946 Properties

Boiling point	591.6±50.0 °C(Predicted)
Density	1.337±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO:20.0(Max Conc. mg/mL);52.57(Max Conc. mM)
form	A crystalline solid
pka	8.18±0.50(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

MKC3946 price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	19152	MKC-3946 ≥98%	1093119-54-0	1mg	$56	2024-03-01	Buy
Cayman Chemical	19152	MKC-3946 ≥98%	1093119-54-0	5mg	$241	2024-03-01	Buy
Cayman Chemical	19152	MKC-3946 ≥98%	1093119-54-0	10mg	$429	2024-03-01	Buy
Cayman Chemical	19152	MKC-3946 ≥98%	1093119-54-0	25mg	$936	2024-03-01	Buy
ChemScene	CS-6002	MKC3946 99.68%	1093119-54-0	50mg	$1200	2021-12-16	Buy

Product number	Packaging	Price	Buy
19152	1mg	$56	Buy
19152	5mg	$241	Buy
19152	10mg	$429	Buy
19152	25mg	$936	Buy
CS-6002	50mg	$1200	Buy

MKC3946 Chemical Properties,Uses,Production

Biological Activity

MKC3946 is a soluble inhibitor of the IRE1α endoribonuclease domain, causing moderate growth inhibition in multiple myeloma cell lines without toxic effects on normal monocytes.

in vivo

In an in vivo model of endoplasmic reticulum stress, MKC-3946 inhibits cleavage of XBP1 and significantly inhibits myeloma cell growth.

target

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MKC3946 Preparation Products And Raw materials

Raw materials

Preparation Products

MKC3946 Suppliers

Global( 61)Suppliers

Target	Value
IRE1α endoribonuclease ()

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Chengdu Henghui Pharm Tec Co. Ltd.	13540674322 15828370308		CHINA	121	55
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
InvivoChem	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Chengdu Henghui Pharm Tec Co. Ltd.	55
Shanghai Boyle Chemical Co., Ltd.	55
MedChemexpress LLC	58

MKC3946 Spectrum

MKC3946(1093119-54-0)¹HNMR

1093119-54-0(MKC3946)Related Search:

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MKC9989 GSK2656157 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine

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MKC3946 MKC3946;MKC-3946;MKC 3946 1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]- 2-Hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde Inositol requiring enzyme 1,inhibit,IRE1,MKC3946,Inhibitor,MKC 3946,MKC-3946 1093119-54-0