Imrecoxib
- CAS No.
- 395683-14-4
- Chemical Name:
- Imrecoxib
- Synonyms
- 2H-Pyrrol-2-one, 1,5-dihydro-3-(4-methylphenyl)-4-[4-(methylsulfonyl)phenyl]-1-propyl-;Imrecoxib;Imrecoxib USP/EP/BP;BAP 909,Cyclooxygenase,Inhibitor,COX,Imrecoxib,inhibit,BAP909
- CBNumber:
- CB03159916
- Molecular Formula:
- C21H23NO3S
- Molecular Weight:
- 369.48
- MDL Number:
- MOL File:
- 395683-14-4.mol
| Boiling point | 604.1±55.0 °C(Predicted) |
|---|---|
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 100 mg/mL (270.65 mM) |
| pka | -2.25±0.60(Predicted) |
| CAS DataBase Reference | 395683-14-4 |
| FDA UNII | SGW6W5758V |
Imrecoxib Chemical Properties,Uses,Production
Clinical Use
Imrecoxib, a new non-steroid anti-inflammtory drug (NSAID), was launched in China with the trade name of Hengyang® for the treatment of osteoarthritis in 2012. It was originally designed and synthesized by Guo and co-workers at the Institute of Materia Medica (IMM) of the Chinese Academy of Medical Sciences in collaboration with Hengrui Pharmaceuticals. Imrecoxib, which is a moderately selective COX-2 inhibitor (with IC50 values against COX-1 and COX-2 being 115 ± 28 nM and 18 4 nM, respectively).
Synthesis
Imrecoxib has had two synthetic routes reported across several publications. The most likely process-scale route to this drug is described in the scheme, which began with 2-bromo-4'-(methylsulfonyl)-acetophenone (84) and p-tolylacetic acid (85) as starting materials. In the presence of base, |á-bromoketone 84 was treated with acid 85 which resulted in lactone 86 in 72% yield across the two-step sequence. Exposure of lactone 86 with propylamine triggered a ring-opening-ring closing reaction, which resulted in imrecoxib (XIII) directly in 85% yield.
Imrecoxib Preparation Products And Raw materials
Raw materials
Preparation Products
Imrecoxib Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3683 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Allikang Pharmaceutical Co., LTD | 0573-87390950 13806705416 | wzj@alicornpharma.com | China | 72 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3419 | 58 |
| Nanjing Daqin Pharmaceutical Technology Co., Ltd. | 025-58470199 18351831988 | sales@daqinpharma.com | China | 312 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |
View Lastest Price from Imrecoxib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Imrecoxib
395683-14-4
|
US $1.00-1.00 / Kg/Bag | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-06-11 | Imrecoxib USP/EP/BP
395683-14-4
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Imrecoxib
395683-14-4
- US $1.00-1.00 / Kg/Bag
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Imrecoxib USP/EP/BP
395683-14-4
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited