Clodronate disodium
- CAS No.
- 22560-50-5
- Chemical Name:
- Clodronate disodium
- Synonyms
- DMDP;Loron;CL2MDP;bm06011;U-82067E;lodronate;Difosfonal;clodronatesodium;sodiumclodronate;chlodronatesodium
- CBNumber:
- CB0318011
- Molecular Formula:
- CH5Cl2NaO6P2
- Molecular Weight:
- 268.88
- MDL Number:
- MFCD01632786
- MOL File:
- 22560-50-5.mol
- MSDS File:
- SDS
| Melting point | >330°C |
|---|---|
| storage temp. | room temp |
| solubility | Freely soluble in water, practically insoluble in ethanol (96 per cent), slightly soluble in methanol. |
| form | Solid |
| color | White to Off-White |
| InChIKey | HJKBJIYDJLVSAO-UHFFFAOYSA-L |
| CAS DataBase Reference | 22560-50-5(CAS DataBase Reference) |
| FDA UNII | Y05R4GCQ1H |
| NCI Drug Dictionary | clodronate disodium |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | SZ7640700 |
| HS Code | 29319090 |
| Toxicity | mouse,LD50,intraperitoneal,780mg/kg (780mg/kg),British UK Patent Application. Vol. #2096889, |
Clodronate disodium price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D4434 | Dichloromethylenediphosphonic acid disodium salt | 22560-50-5 | 1g | $347 | 2024-03-01 | Buy |
| TRC | C586875 | ClodronicAcidDisodiumSaltHydrate | 22560-50-5 | 5g | $205 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20495 | Clodronic acid disodium salt | 22560-50-5 | 1g | $80 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20495 | Clodronic acid disodium salt | 22560-50-5 | 2g | $125 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | ING0002754 | CLODRONATE DISODIUM 95.00% | 22560-50-5 | 50MG | $704.55 | 2021-12-16 | Buy |
Clodronate disodium Chemical Properties,Uses,Production
Description
Clodronate disodium is a bone resorption inhibitor, useful as adjunct therapy in the treatment of osteolytic bone metastases and malignant hypercalcemia.
Chemical Properties
White Solid
Originator
Proctor & Gamble (USA)
Uses
Clodronic Acid Disodium Salt Hydrate is a bisphosphonate antiresorptive agent; bone resorption inhibitor.
Definition
ChEBI: The disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used (generally as the tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteoly ic lesions and bone pain associated with skeletal metastases.
brand name
Bonefos (Leiras Oy, Finland).
Hazard
Moderately toxic by ingestion.
Biochem/physiol Actions
Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.
Clinical Use
Bisphosphonate: Management of osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastases in patients with breast cancer or multiple myeloma
Safety Profile
A poison by intravenous route. Moderately toxic by ingestion, intraperitoneal routes. When heated to decomposition it emits toxic vapors of PO, and Cl-
Drug interactions
Potentially hazardous interactions with other drugs
Cytotoxics: concentration of estramustine increased.
Metabolism
Clodronate is not metabolised.
Over 70% of an intravenous dose is excreted unchanged
in the urine within 24 hours, the remainder being
sequestered to bone tissue. The substance which is bound
to bone is excreted more slowly, and the renal clearance is
about 75% of the plasma clearance.
Clodronate disodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 961 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3657 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
View Lastest Price from Clodronate disodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-12 | Clodronate disodium
22560-50-5
|
US $50.00 / Kg/Bag | 1Kg/Bag | 98% | 200kg/month | XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | |
 |
2021-08-12 | Dichloromethylenediphosphonic acid disodium salt
22560-50-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-05-04 | Clodronate disodium
22560-50-5
|
US $0.00-0.00 / KG | 1KG | 99.0% | 600 Tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Clodronate disodium
22560-50-5
- US $50.00 / Kg/Bag
- 98%
- XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
-
- Dichloromethylenediphosphonic acid disodium salt
22560-50-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Clodronate disodium
22560-50-5
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
22560-50-5(Clodronate disodium)Related Search:
1of4