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2-Amino-2-methyl-1-propanol

CAS No.
124-68-5
Chemical Name:
2-Amino-2-methyl-1-propanol
Synonyms
2-AMINO-2-METHYLPROPAN-1-OL;AMP-95;2-Amino-2-methylpropanol;1,1-Dimethyl-2-hydroxyethylamine;Aminomethylpropanol;2-methyl-2-amino-1-propanol;Karl Fischer;2,2-Diethyl-ethanolamine;Isobutanolamine;2-Aminoisobutanol
CBNumber:
CB0320043
Molecular Formula:
C4H11NO
Molecular Weight:
89.14
MDL Number:
MFCD00008051
MOL File:
124-68-5.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02

2-Amino-2-methyl-1-propanol Properties

Melting point 24-28 °C (lit.)
Boiling point 165 °C (lit.)
Density 0.934 g/mL at 25 °C (lit.)
vapor density 3 (vs air)
vapor pressure <1 mm Hg ( 25 °C)
refractive index n20/D 1.4455(lit.)
Flash point 153 °F
storage temp. Store below +30°C.
solubility H2O: 0.1 M at 20 °C, clear, colorless
form Low Melting Solid
color Colorless
Specific Gravity 0.934
PH Range 9.0 - 10.5
PH 11.0-12.0 (25℃, 0.1M in H2O)
pka 9.7(at 25℃)
Odor at 100.00?%. mild ammonia
Water Solubility miscible
λmax λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
Merck 14,449
BRN 505979
Stability Stable. Combustible. Incompatible with strong oxidizing agents. May present an explosion hazard if heated.
InChIKey CBTVGIZVANVGBH-UHFFFAOYSA-N
LogP -0.63 at 20℃
Indirect Additives used in Food Contact Substances 2-AMINO-2-METHYL-1-PROPANOL
FDA 21 CFR 175.105
CAS DataBase Reference 124-68-5(CAS DataBase Reference)
FDA UNII LU49E6626Q
NIST Chemistry Reference 1-Propanol, 2-amino-2-methyl-(124-68-5)
EPA Substance Registry System 2-Amino-2-methyl-1-propanol (124-68-5)
Cosmetics Info Aminomethyl Propanol
UNSPSC Code 12352104
NACRES NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H412
Precautionary statements  P264-P273-P280-P302+P352-P305+P351+P338-P332+P313
Hazard Codes  Xi,F
Risk Statements  36/38-52/53
Safety Statements  61-26
RIDADR  2735
WGK Germany  1
RTECS  UA5950000
Autoignition Temperature 438 °C
Hazard Note  Harmful/Flammable
TSCA  Yes
PackingGroup  III
HS Code  29221990
Hazardous Substances Data 124-68-5(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 2900 mg/kg LD50 dermal Rabbit > 2000 mg/kg
NFPA 704
2
2 0

2-Amino-2-methyl-1-propanol price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.01465 2-Amino-2-methyl-1-propanol for synthesis 124-68-5 250ML $51.5 2024-03-01 Buy
Sigma-Aldrich 8.01465 2-Amino-2-methyl-1-propanol for synthesis 124-68-5 1L $95.4 2024-03-01 Buy
Sigma-Aldrich 8.01465 2-Amino-2-methyl-1-propanol for synthesis 124-68-5 2.5L $224 2024-03-01 Buy
Sigma-Aldrich 8.01465 2-Amino-2-methyl-1-propanol for synthesis 124-68-5 25L $1130 2024-03-01 Buy
Sigma-Aldrich 08578 2-Amino-2-methyl-1-propanol BioUltra, ≥99.0% (GC) 124-68-5 50ml $194 2024-03-01 Buy
Product number Packaging Price Buy
8.01465 250ML $51.5 Buy
8.01465 1L $95.4 Buy
8.01465 2.5L $224 Buy
8.01465 25L $1130 Buy
08578 50ml $194 Buy

2-Amino-2-methyl-1-propanol Chemical Properties,Uses,Production

Industrial uses

Because 2-Amino-2-methyl-1-propanol has the advantages of excellent absorption and desorption capacity, high loading capacity, and low replenishment cost. AMP is one of the promising amines considered for usage in the industrial scale post-combustion CO2 capture technology[1]. At present, there are a large number of studies on the performance of 2-Amino-2-methyl-1-propanol for CO2 adsorption. Using 2-amino-2-methyl-1-propanol (AMP) as the core adsorbent and silica as the shell, the AMP microcapsules prepared are expected to replace conventional adsorbents to achieve carbon dioxide capture in cold environments[2].

Uses

2-Amino-2-methyl-1-propanol is also used in ATR-FTIR spectroscopic investigation of the carbon monoxide absorption characteristics of a series of heterocyclic diamines.

Uses

2-Amino-2-methylpropanol is used for the preparation of buffer solutions, suitable for the determination of alkaline phosphatase.

Uses

2-Amino-2-methyl-1-propanol has been used as an component in enzyme assay for screening the alkaline phosphatase activity in sarcoma osteogenic (SaOS-2) cells..

General Description

A clear light colored liquid. Insoluble in water and about the same density as water. Flash point 172°F. Used to make other chemicals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2-Amino-2-methyl-1-propanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Hazard

Toxic by ingestion.

Health Hazard

Causes severe irritation. Inhalation may be fatal as a result of spasm, inflammation, and edema of laryns and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting.

Fire Hazard

Special Hazards of Combustion Products: Emits toxic fumes during fire conditions.

Biochem/physiol Actions

2-Amino-2-methyl-1-propanol is a substituted aliphatic alcohol and is used majorly as a pH balancer in cosmetic formulations. It has phototoxic effect as it can interact and penetrate above the sebum layer. However, it is not carcinogenic.

Safety Profile

On March 21, 2014, the Environmental Protection Agency (EPA) issued a direct final rule with a parallel proposal identifying 2-Amino-2-methyl-1-propanol (also known as AMP) as a chemical compound that it will no longer be regulated as a volatile organic compound (VOC) under the Clean Air Act. This will remove AMP from regulatory requirements related to controlling VOC emissions in order to meet the national ambient air quality standards (NAAQS) for ozone. EPA will add AMP to the list of negligibly reactive compounds in EPA’s regulatory definition of VOC.
AMP is used for pigment dispersion in water-based coatings such as house paints. Excluding this compound from the regulatory definition of VOC, facilitates access to AMP for manufacturers of water-based coatings in order to meet VOCs limits without impairing the performance of their products or using other more toxic chemicals.

Synthesis

The synthesis of 2-Amino-2-methyl-1-propanol is as follows:

In a 1L three-neck flask with mechanical stirring, first add 200ml of water, add a few drops of dilute sulfuric acid to make it slightly acidic (pH=3.5-4), then heat to 40-50, and start adding 99.0 at the same time. 2,2-Dimethylaziridine and 400ml dilute sulfuric acid aqueous solution, keep the temperature and slightly acidic condition, drop 2,2-dimethylaziridine, then continue to react at this temperature 1h, then under reduced pressure distillation to remove 80% of the water, add 500ml ethanol to the obtained system, neutralize with 30% sodium hydroxide to pH=9.5-10, filter and remove the salt, the obtained filtrate is distilled out of ethanol under normal pressure , And then distilled under reduced pressure to obtain crude 2-amino-2-methyl-1-propanol. This crude product is then rectified to obtain 112.9g 2-amino-2-methyl-1-propanol refined product with a yield of about 91.0%, chromatographic purity is about 99.4%.
synthesis of 2-Amino-2-methyl-1-propanol

Purification Methods

Purify it by distilling and fractional freezing. The hydrochloride has m 204o-206o. [Beilstein 4 III 783, 4 IV 1740.]

Toxics Screening Level

The initial threshold screening level (ITSL) for 1-amino-2-methyl-1-propanol {AMP) is 4 μg/m3 based on an annual averaging time.

References

[1] Tan W, et al. Atmospheric Chemistry of 2-Amino-2-methyl-1-propanol: A Theoretical and Experimental Study of the OH-Initiated Degradation under Simulated Atmospheric Conditions. The Journal of Physical Chemistry A, 2021; 125: 7502–7519.[2] Rama ;S, et al. Encapsulation of 2-amino-2-methyl-1-propanol with tetraethyl orthosilicate for CO2 capture. Frontiers of Chemical Science and Engineering, 2019; 13: 672–683.

32831-43-9
124-68-5
Synthesis of 2-Amino-2-methyl-1-propanol from Propanamide, 3-hydroxy-2,2-dimethyl-
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2-Amino-2-methyl-1-propanol pictures 2025-02-07 2-Amino-2-methyl-1-propanol
124-68-5
US $80.00 / kg 1kg 99% 5000 Hebei Zhuanglai Chemical Trading Co.,Ltd
AMP pictures 2025-02-07 AMP
124-68-5
US $60.00 / KG 1KG 99 5000 Hebei Zhuanglai Chemical Trading Co.,Ltd
2-Amino-2-methyl-1-propanol pictures 2025-02-06 2-Amino-2-methyl-1-propanol
124-68-5
US $0.00 / Kg/Drum 1KG 95%min 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
  • AMP pictures
  • AMP
    124-68-5
  • US $60.00 / KG
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iso-Butanolamine 2-Amino-2-methyl-1-propanol, 10% water 2-Amino-2-methyl-1-propanol,99% 2-Amino-2-Methyl-1-Propanol, May Cont. up to ca 5% Water 2-Amino-2-Methyl-1-Propano AMP 2-Amino-2-methyl-1-propanol ,95% 2-Amino-2-methyl-1-propanol,β-Aminoisobutyl alcohol, AMP 2-Amino-2-methyl-1-p 2-AMINO-2-METHYL-1-PROPANOL,0.1MBUFFERSOLUTION 2-AMINO-2-METHYL-1-PROPANOL,BUFFERCONCENTRATE 2-AMINO-2-METHYLPROPAN-1-OL 95% PHARMA GRADE 2-AMINO-2-METHYL-1-PROPANOL, BIOTECH 95% (5% WATER TO MAINTAIN LIQUIDITY) Aqualine Electrolyte AD-G 2-Amino-2-methyl-1-propanol, 95%, may cont. up to ca 5% water AMP,Buffer 2-AMINO-2-METHYL-1-PROPANOL pure β-Aminoisobutyl alcohol, AMP 2-Methyl-2-aminopropanol-1 2-amino-1-hydroxy-2-methylpropane 2-Amino-2,2-dimethylethanol 2-Aminodimethylethanol 2-Amino-iso-butanol 2-Hydroxymethyl-2-propylamine LABOTEST-BB LT01409642 β-Aminoisobutyl alcohol 2-Amino-2-methyl-1-propanol AMP 2-Amino-2-methyl-1-propanol, Technical Grade, 95% AMP, Technical Grade, 95% 2-AMino-2-Methyl alcohol 1-(Hydroxymethyl)-1-(methyl)ethylamine 2-AMino-2-Methyl-1-propanol, 99% 1LT 2-AMino-2-Methyl-1-propanol, 95%, May cont. ca 5% water 2-METHYL-2-AMINO PROPANOL 2-AMINO-ISO-BUTYL ALCOHOL 2-AMINO-2-METHYL-1-PROPANOL 2-AMINO-2-METHYL-1-PROPANOL FOR SYNTHESI 1-Hydroxy-2-methylpropan-2-amine, 2-Amino-1-hydroxy-2-methylpropane 2-AMino-2-Methylpropanol (>90%) AMP buffer concentrate 2-AMino-2-Methyl-1-propanol ~5% Water, technical grade, 90% 2-AMino-2-Methyl-1-propanol technical, >=90% (GC) 2-AMINO-2-METHYL-1-PROPANOL BIOULTRA 2-AMINO-2-METHYL-1-PROPANOL BIOXTRA 2-Amino-2-methyl-1-propanol, 95%, may contain 5% water B-AMINOISOBUTANOL BETA-AMINOISOBUTANOL TIMTEC-BB SBB004396 AMP~Isobutanolamine 2-Amino-2-methyl-1-propanol;2-Amino-2-methyl-propan-1-ol; Karl Fischer; AQUALINE ELECTROLYTE AD-G 2-AMINO-2-METHYL-1-PROPANOL FREE BASE 2-AMINO-2-METHYL-1-PROPANOL SIGMAULTRA AmpBuffer,95% 2-Amino-2-Methyl-1-Propanol,>98% AmpBuffer,0.1MSolution Amino-2,2-dimethylethanol Amino-2-methyl-1-propanol Aminoisobutanol AMP Regular ampregular