NS-2028
- CAS No.
- 204326-43-2
- Chemical Name:
- NS-2028
- Synonyms
- NS-2028;NS 2028 - CAS 204326-43-2 - Calbiochem;4-H-BROMO-1,2,4-OXADIAZOLE(3,4-ALPHA)BENZ(B)OXAZIN-1-ONE;NS 2028,inhibit,Inhibitor,NS-2028,NS2028,Guanylate Cyclase;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZ(B)(1,4)OXAZIN-1-ONE;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZO(B)(1,4)OXAZIN-1-ONE;8-bromo-4~{H}-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one;8-Bromo-1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]Benzoxazin-1-One;1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-;8-BROMO-4H-2,5-DIOXA-3,9B-DIAZA CYCLOPENTA[A]NAPHTHALEN-1-ONE
- CBNumber:
- CB0326227
- Molecular Formula:
- C9H5BrN2O3
- Molecular Weight:
- 269.05
- MDL Number:
- MFCD01530052
- MOL File:
- 204326-43-2.mol
| Melting point | 160～170℃ |
|---|---|
| Boiling point | 353.8±52.0 °C(Predicted) |
| Density | 2.06±0.1 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | DMSO: 13 mg/mL |
| pka | -1.18±0.20(Predicted) |
| form | solid |
| color | white |
| FDA UNII | KU8K3G4867 |
NS-2028 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 492030 | NS 2028 | 204326-43-2 | 5mg | $318 | 2024-03-01 | Buy |
| Sigma-Aldrich | N211 | NS 2028 solid | 204326-43-2 | 5mg | $267 | 2022-05-15 | Buy |
| Cayman Chemical | 81600 | NS 2028 ≥98% | 204326-43-2 | 1mg | $47 | 2024-03-01 | Buy |
| Cayman Chemical | 81600 | NS 2028 ≥98% | 204326-43-2 | 5mg | $206 | 2024-03-01 | Buy |
| Sigma-Aldrich | N211 | NS 2028 solid | 204326-43-2 | 25mg | $1060 | 2022-05-15 | Buy |
NS-2028 Chemical Properties,Uses,Production
Uses
NS-2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates is inhibited by NS-2028 with an IC50 value of 17 nM, making it about 4.7 fold more potent than ODQ, which has an IC50 value of 80 nM for inhibition of soluble guanylyl cyclase in the same assay. NS-2028 does not inhibit particulate guanylyl cyclase or adenylyl cyclase.
Uses
NS-2028 potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). NS-2028 blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA. NS-2028 inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).
storage
Store at +4°C
NS-2028 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Luan lingxi Chemical Products Co., Ltd | 18712378369 | 690240416@qq.com | China | 282 | 58 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 10007 | 58 | |
| Syntechem Co.,Ltd. | 519-88298820 15861130028 | info@syntechem.com | China | 242 | 58 |
| Aikon International Limited | 025-66113011 18112977050 | cb6@aikonchem.com | China | 15495 | 58 |
