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NS-2028

NS-2028
NS-2028 structure
CAS No.
204326-43-2
Chemical Name:
NS-2028
Synonyms
NS-2028;NS 2028 - CAS 204326-43-2 - Calbiochem;4-H-BROMO-1,2,4-OXADIAZOLE(3,4-ALPHA)BENZ(B)OXAZIN-1-ONE;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZ(B)(1,4)OXAZIN-1-ONE;8-Bromo-1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]Benzoxazin-1-One;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZO(B)(1,4)OXAZIN-1-ONE;8-bromo-4~{H}-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one;8-BROMO-4H-2,5-DIOXA-3,9B-DIAZA CYCLOPENTA[A]NAPHTHALEN-1-ONE
CBNumber:
CB0326227
Molecular Formula:
C9H5BrN2O3
Formula Weight:
269.05
MOL File:
204326-43-2.mol

NS-2028 Properties

Melting point:
160~170℃
storage temp. 
+2C to +8C
solubility 
DMSO: 13 mg/mL
form 
solid
color 
white

SAFETY

WGK Germany  3

NS-2028 price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N211 NS 2028 solid 204326-43-2 5mg $234 2018-11-20 Buy
Sigma-Aldrich 492030 NS 2028 204326-43-2 5mg $239 2018-11-20 Buy
Cayman Chemical 81600 NS-2028 ≥98% 204326-43-2 1mg $37 2018-11-13 Buy
Cayman Chemical 81600 NS-2028 ≥98% 204326-43-2 5mg $167 2018-11-13 Buy
Sigma-Aldrich N211 NS 2028 solid 204326-43-2 25mg $926 2018-11-20 Buy

NS-2028 Chemical Properties,Uses,Production

Uses

NS-2028 potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). NS-2028 blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA. NS-2028 inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

Uses

NS-2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates is inhibited by NS-2028 with an IC50 value of 17 nM, making it about 4.7 fold more potent than ODQ, which has an IC50 value of 80 nM for inhibition of soluble guanylyl cyclase in the same assay. NS-2028 does not inhibit particulate guanylyl cyclase or adenylyl cyclase.

NS-2028 Preparation Products And Raw materials

Raw materials

Preparation Products


NS-2028 Suppliers

Global( 29)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32363 50
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9915 55
Shanghai SunSyn Pharmaceutical Co., Ltd. 021-61901385 18621020637
021-61901385 sales@sunsynpharma.com China 237 55
EMMX Biotechnology LLC 888-539-0666
888-539-0666 info@emmx.com United States 8455 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885
021-65675885 info@efebio.com China 9934 58
Shandong XiYa Chemical Industry Co., Ltd 4008-626-111
0539-6365991 3229735657@qq.com China 26791 60
Shandong Ono Chemical Co., Ltd. 0539-6362799(To 20)
0539-6362799(To 20) 775388075@qq.com China 10018 58
Syntechem Co.,Ltd. +86-519-8385 0735
+86-519-8829 8820 info@syntechem.com China 2107 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 400-900-4166
1514189587@qq.com China 52527 58

204326-43-2(NS-2028)Related Search:


  • 8-bromo-4~{H}-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
  • NS 2028 - CAS 204326-43-2 - Calbiochem
  • NS-2028
  • 8-BROMO-4H-2,5-DIOXA-3,9B-DIAZA CYCLOPENTA[A]NAPHTHALEN-1-ONE
  • 8-Bromo-1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]Benzoxazin-1-One
  • 204326-43-2
  • C9H5BrN2O3
  • Cyclic Nucleotide Metabolism
  • Guanylyl Cyclase Inhibitors
  • 4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZ(B)(1,4)OXAZIN-1-ONE
  • 4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZO(B)(1,4)OXAZIN-1-ONE
  • 4-H-BROMO-1,2,4-OXADIAZOLE(3,4-ALPHA)BENZ(B)OXAZIN-1-ONE
  • G Proteins and Cyclic Nucleotides
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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