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ChemicalBook >> CAS DataBase List >>L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI)

L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI)

L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) Structure
L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) structure
CAS No.
161511-45-1
Chemical Name:
L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI)
Synonyms
VE 13045;SDZ 224015,SDZ 224 015;Z-Val-Ala-Asp(OEt)-CH2-DCB;L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI)
CBNumber:
CB03285648
Molecular Formula:
C30H35Cl2N3O9
Molecular Weight:
652.52
MDL Number:
MOL File:
161511-45-1.mol
Last updated:2023-05-21 10:59:17
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L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) Properties

Boiling point 861.9±65.0 °C(Predicted)
Density 1.299±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 11.05±0.46(Predicted)

L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) Chemical Properties,Uses,Production

Biological Activity

SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM)[1][2]. SDZ 224-015 (0.3-300 μg/kg) potently reduces carrageenin-induced paw oedema[2].SDZ 224-015 (0.2-5 mg/kg, p.o.) displays analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test, significant at a dose of 1 mg/kg[2].

References

[1]. Martin A Redhead, et al. Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Sci Rep. 2021 Jun 24;11(1):13208. [2]. P R Elford, et al. Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6.

L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 eric@peptidego.com China 6347 58
Wuxi Helen Biotechnology Co., Ltd., 0510-85629785 18013409632 sales@reading-chemicals.com China 14092 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 17306812703 3007955328@qq.com China 5949 58
Hangzhou Baige Pharmaceutical Technology Co. , Ltd. 0571-85350119 15888826472 15888826472@163.com China 2729 58
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd 18014456767 18014456767 wenxi@jszkhy.com China 1349 58
Hangzhou Beiputai Biopharmaceutical Co., Ltd 0571-85350119 13305819357 bptsales@163.com China 3577 58
Supplier Advantage
Zhejiang J&C Biological Technology Co.,Limited 		58
Hangzhou Peptidego Biotech Co.,Ltd. 58
Wuxi Helen Biotechnology Co., Ltd., 58
TargetMol Chemicals Inc. 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 58
Hangzhou Baige Pharmaceutical Technology Co. , Ltd. 58
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd 58
Hangzhou Beiputai Biopharmaceutical Co., Ltd 58

161511-45-1(L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI))Related Search:

BENZYLOXYCARBONYL-L-VALYL-L-LYSYL-L-METHIONINE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE Z-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE Z-VAL-LYS-LYS-ARG-AFC Z-VRPR-FMK (trifluoroacetate salt) Z-VAL-VAL-ARG-AMC
Z-VAL-ALA-ASN-AMC Z-VDVAD-AFC Z-YVAD-AFC Z-VEID-AFC Z-TYR-SER-OH
UROKINASE SUBSTRATE I, COLORIMETRIC Z-VAL-ALA-ASP-AMC

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L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) Z-Val-Ala-Asp(OEt)-CH2-DCB VE 13045 SDZ 224015,SDZ 224 015 161511-45-1 C30H35Cl2N3O9