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Flomoxef

Flomoxef structure

CAS No.: 99665-00-6

Chemical Name:: Flomoxef

Synonyms: FMOX;Flumarin;FLOMOXEF;FLOMOEXF;Flomoxef Acid;Flomoxef Monomer;Flomoxef USP/EP/BP;8-Pyridinecarboxamide,N-phenyl-;Flomoxef Sodium、Flumarin、Sodium Flomoxef;(6R,7R)-7α-[[(Difluoromethyl)thio]acetylamino]-7-methoxy-8-oxo-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-1-aza-5-oxabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CBNumber:: CB0328847

Molecular Formula:: C15H18F2N6O7S2

Molecular Weight:: 496.47

MDL Number:: MFCD00865115

MOL File:: 99665-00-6.mol

MSDS File:: SDS

Last updated:2023-10-24 17:36:38

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Flomoxef Properties

Melting point	82.5-87.5°
Density	1.85±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	soluble in DMSO, Methanol
form	Solid
pka	3.26±0.40(Predicted)
color	Off-White
CAS DataBase Reference	99665-00-6(CAS DataBase Reference)
FDA UNII	V9E5U5XF42
ATC code	J01DC14

Flomoxef price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	F401850	Flomoxef	99665-00-6	1.0mg	$630	2021-12-16	Buy
American Custom Chemicals Corporation	API0007274	FLOMOXEF 95.00%	99665-00-6	0.5MG	$636	2021-12-16	Buy
American Custom Chemicals Corporation	API0007274	FLOMOXEF 95.00%	99665-00-6	1G	$1686.3	2021-12-16	Buy

Product number	Packaging	Price	Buy
F401850	1.0mg	$630	Buy
API0007274	0.5MG	$636	Buy
API0007274	1G	$1686.3	Buy

Flomoxef Chemical Properties,Uses,Production

Description

Flomoxef sodium is a P-lactamase resistant oxacephalosporin. Its spectrum of activity is similar to that of cefazolin and moxalactam, but with better efficacy against Staphylococcus aureus and Bacteroides fragilis. Flomoxef is reported effective in the treatment of post-operative, urinary tract and abdominal cavity infections.

Originator

Shionogi (Japan)

Uses

Flomoxef is an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.

Definition

ChEBI: Flomoxef is a second-generation oxacephem antibiotic in which the oxazine ring is substituted at C-3 with a hydroxyethyl-substituted tetrazolylthiomethyl group and the azetidinone ring carries 7alpha-methoxy and 7beta-{2-[(difluoromethyl)thiomethyl]acetamido} substituents. It has a role as an antibacterial drug. It is a N-acyl-amino acid, an oxacephem and an organonitrogen heterocyclic antibiotic.

brand name

Flumari

Antimicrobial activity

An oxa-cephem which differs from latamoxef in the side chains carried at the 7-amino and C-3 positions, but which retains the 7-methoxy group that confers β-lactamase stability. The methyl group of the methylthiotetrazole side chain of latamoxef has been modified to hydroxymethyl in an attempt to avoid the undesirable side effects, while the side chain at the 7-amino position is F2-CH-S-CH2-.
Activity is similar to that of latamoxef, but activity against Staph. aureus is improved and it is claimed to be a poor inducer of penicillin-binding protein 2′, which is associated with resistance in methicillin-resistant strains.
Intravenous injection of 2 g achieves a peak plasma concentration of around 50 mg/L, falling to 2.6 mg/L after 6 h. The plasma half-life is about 50 min. It appears to be well distributed and penetrates moderately well into lung, mucosal tissue of the middle ear and bone.
Flomoxef does not seem to be prone to the effects on platelet function of latamoxef and it has a less marked effect on vitamin K metabolism. It does not cause a disulfiram-like reaction with alcohol.
It is available in Japan, where it appears safe and effective in a wide range of infections.

Flomoxef Preparation Products And Raw materials

Raw materials

ETHYL THIOGLYCOLATE Ethanol Potassium hydroxide Sodium chloride Triethylamine

Sodium ethoxide Magnesium sulfate Iodomethane

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Preparation Products

Flomoxef Suppliers

Global( 90)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9705	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29627	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58

View Lastest Price from Flomoxef manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-10-24	Flomoxef 99665-00-6	US $0.00-0.00 / kg	1kg	99	20tons	Hebei Yanxi Chemical Co., Ltd.
2022-11-23	Flomoxef 99665-00-6	US $1.00 / kg	1kg	99%	300MT/month	Hebei Duling International Trade Co. LTD
2021-11-06	Flomoxef 99665-00-6	US $0.00 / Kg/Drum	1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD

Flomoxef
99665-00-6
US $0.00-0.00 / kg
99
Hebei Yanxi Chemical Co., Ltd.

Flomoxef
99665-00-6
US $1.00 / kg
99%
Hebei Duling International Trade Co. LTD

Flomoxef
99665-00-6
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

99665-00-6(Flomoxef)Related Search:

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4-(Diethylamino)salicylaldehyde Diphenolic acid DL-α-Tocopherol Acetaminophen 2-HYDROXYETHYL N-PENTYL SULPHIDE, 95

3-AZETIDINOL 2-(5-Mercaptotetrazole-1-yl)ethanol 1-Ethyl-1H-1,2,3,4-tetrazole-5-thiol 1-METHYL-3-AZETIDINOL 3-METHOXY-AZETIDINE

Flomoxef ACETAMINOPHENOL BP/USP Flomoxef Jp13

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FLOMOXEF 5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)- FLOMOXEF [5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)- ] 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, (6R,7R)- Flumarin FMOX (-)-(6R,7R)-7-(2-((Difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R,7R)-7α-[[(Difluoromethyl)thio]acetylamino]-7-methoxy-8-oxo-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-1-aza-5-oxabicyclo[4.2.0]oct-2-ene-2-carboxylic acid [6R,7R,(-)]-7α-[[2-(Difluoromethylthio)acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-[(difluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-,(6R,7R)- (6R,7R)-7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (6R-cis)7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (6R-cis)-7-[[[(Difluoromethyl)thio]acetyl]amino]-3_[[[1-(2-hy-droxyethyl)-1H-tetrazol-5-y1]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R,7R)-7-[[2-(difluoromethylsulfanyl)acetyl]amino]-3-[[1-(2-hydroxyethyl)tetrazol-5-yl]sulfanylmethyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R,7R)-7-[[2-(difluoromethylthio)-1-oxoethyl]amino]-3-[[[1-(2-hydroxyethyl)-5-tetrazolyl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Flomoxef Sodium、Flumarin、Sodium Flomoxef Flomoxef USP/EP/BP FLOMOEXF Flomoxef Acid 8-Pyridinecarboxamide,N-phenyl- Flomoxef Monomer 99665-00-6 C15H18F2N6O7S2 C15H18N6O7F2S2 Heterocycles Intermediates & Fine Chemicals Pharmaceuticals