Saikosaponin D
- CAS No.
- 20874-52-6
- Chemical Name:
- Saikosaponin D
- Synonyms
- Saikoside d;saikosaponin;saikosaponins;SAIKOSAPONIN D;Saikosaponian D;SAILKOSAPONIN D;SAILKOSAPONINS D;SAIKOSAPONIN D(RG);SAIKOSAPONIN B2(P);Saikosaponin d std.
- CBNumber:
- CB0329374
- Molecular Formula:
- C42H68O13
- Molecular Weight:
- 780.99
- MDL Number:
- MFCD09028095
- MOL File:
- 20874-52-6.mol
| Melting point | 212～218℃ |
|---|---|
| Boiling point | 893.7±65.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, Refrigerator, Under inert atmosphere |
| solubility | Methanol (Slightly), Pyridine (Slightly) |
| form | Solid |
| pka | 12.83±0.70(Predicted) |
| color | White to Off-White |
| Stability | Hygroscopic |
| LogP | 3.756 (est) |
| CAS DataBase Reference | 20874-52-6 |
| EWG's Food Scores | 1 |
| FDA UNII | UR635J3F00 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Safety Statements | 24/25 |
| RTECS | VN3099000 |
| HS Code | 29389090 |
Saikosaponin D price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | S083915 | SaikosaponinD | 20874-52-6 | 2.5mg | $50 | 2021-12-16 | Buy |
| TRC | S083915 | SaikosaponinD | 20874-52-6 | 10mg | $80 | 2021-12-16 | Buy |
| Usbiological | 297731 | Saikosaponin D | 20874-52-6 | 5mg | $319 | 2021-12-16 | Buy |
| Usbiological | 300910 | Saikosaponin D | 20874-52-6 | 20mg | $390 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb594260 | Saikosaponin D | 20874-52-6 | 100mg | $418.2 | 2021-12-16 | Buy |
Saikosaponin D Chemical Properties,Uses,Production
Description
Saikosaponin D is a triterpene saponin found in Bupleurum that exhibits antioxidative, immunomodulatory, anti-fibrotic, anti-angiogenic, anticancer, and chemopreventive activities. Saikosaponin D increases activity of superoxide dismutase, catalase, and glutathione peroxidase and decreases activity of malondialdehyde in cellular models of oxidative damage. In other in vitro models, saikosaponin D increases secretion of IL-12, maturation of dendritic cells, and proliferation of lymphocytes. Saikosaponin D inhibits SERCA, increasing intracellular Ca2+ and inducing autophagy. In vivo, this compound decreases severity of fibrosis. In embryos, saikosaponin D decreases microvessel formation. Additionally, this compound decreases tumor formation in DEN-treated animal models and suppresses expression of CEBP-β and COX-2. Saikosaponin D also induces apoptosis and activation of caspases 3 and 7 in hepatocellular carcinoma cells. Saikosaponin D is a Glucocorticoid receptor agonist. It is a COX-2 and iNOS inhibitor.
Uses
Saikosaponin d (SSd) is an important active component of Bupleurum scorzonerifolium Willd., a traditional Chinese medicinal herb. Saikosaponins such as Saikosaponin D are used to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to.
Uses
Saikosaponin D is an inhibitor of proliferation of human prostate cancer cells through arresting the cell cycle.
Biological Activity
Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.
Clinical claims and research
We have previously identified a small-molecule, saikosaponin-d (Ssd), that exhibits anti-inflammatory effect via the suppression of NF-κB, NF-AT and AP-1 signaling. We recently showed that Ssd potentiated the anti-cancer potency of TNF-α through NF-κB inhibition. Ssd is one of the major triterpenoid saponins derived from Bupleurum falcatum L. (Umbelliferae), which is commonly prescribed for inflammatory and infectious diseases, and its active component Ssd was reported to have immuno-modulatory, anti-inflammatory, anti-bacterial, anti-viral and anti-cancer activities.
Saikosaponin D Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Related articles
- Application of saikosaponin-d in cancer
- Saikosaponin-d is a novel autophagic inducer, from a medicinal plant that induces autophagy in various types of cancer cells
- Jan 13，2022
View Lastest Price from Saikosaponin D manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Saikosaponin D
20874-52-6
|
US $0.00 / kg | 1kg | 98% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2024-04-09 | Saikosaponin D
20874-52-6
|
US $0.00-0.00 / kg | 1kg | 95%; 98% HPLC | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2023-02-24 | Saikosaponin D
20874-52-6
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Saikosaponin D
20874-52-6
- US $0.00 / kg
- 98%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Saikosaponin D
20874-52-6
- US $0.00-0.00 / kg
- 95%; 98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Saikosaponin D
20874-52-6
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.