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PTP1B-IN-2

PTP1B-IN-2 structure

CAS No.: 1919853-46-5

Chemical Name:: PTP1B-IN-2

Synonyms: MDK3465;PTP1B-IN-2;PTP1B inhibitor 2;PTP1B-IN-2;PTP1B INHIBITOR 2;Inhibitor,PTP-1B-IN-2,inhibit,PTP1BIN2,Phosphatase,PTP1B IN 2;Benzoic acid, 5-[[[4-[(2-methoxy-2-oxoethyl)(methylsulfonyl)amino]phenyl]methyl][(phenylmethyl)sulfonyl]amino]-2-[(4-methylphenyl)methoxy]-, methyl ester

CBNumber:: CB03309540

Molecular Formula:: C34H36N2O9S2

Molecular Weight:: 680.79

MDL Number:

MOL File:: 1919853-46-5.mol

Last updated:2023-05-21 10:59:17

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PTP1B-IN-2 Properties

Boiling point	813.4±75.0 °C(Predicted)
Density	1.350±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form	A solid
pka	-3.81±0.50(Predicted)

PTP1B-IN-2 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-6881	PTP1B-IN-2 99.85%	1919853-46-5	100mg	$2520	2021-12-16	Buy
Ambeed	A949653	PTP1B-IN-2 98%	1919853-46-5	1mg	$63	2021-12-16	Buy
Crysdot	CD38000036	PTP1B-IN-2 98%	1919853-46-5	1mg	$105	2021-12-16	Buy
Ambeed	A949653	PTP1B-IN-2 98%	1919853-46-5	5mg	$107	2021-12-16	Buy
Ambeed	A949653	PTP1B-IN-2 98%	1919853-46-5	10mg	$139	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-6881	100mg	$2520	Buy
A949653	1mg	$63	Buy
CD38000036	1mg	$105	Buy
A949653	5mg	$107	Buy
A949653	10mg	$139	Buy

PTP1B-IN-2 Chemical Properties,Uses,Production

Biological Activity

PTP1B-IN-2 (MDK3465, Ptp1B-In-2, Compound P6) is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B) with IC50 of 50 nM. It enhances insulin-mediated phosphorylation of insulin receptor beta (IRβ) and insulin-stimulated glucose uptake.

in vitro

PTP1B-IN-2 displays more than 40-fold selectivity for PTP1B over SHP-2 and LAR and 15-fold higher selectivity for PTP1B over the highly homologous TCPTP.

target

Target	Value
PTP1B (Cell-free assay)	50 nM

PTP1B-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

PTP1B-IN-2 Suppliers

Global( 47)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7892	56
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4121	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Career Henan Chemica Co	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Shanghai Lollane Biological Technology Co.,Ltd.	55

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PTP1B-IN-2 MDK3465 PTP1B inhibitor 2 PTP1B-IN-2;PTP1B INHIBITOR 2 Inhibitor,PTP-1B-IN-2,inhibit,PTP1BIN2,Phosphatase,PTP1B IN 2 Benzoic acid, 5-[[[4-[(2-methoxy-2-oxoethyl)(methylsulfonyl)amino]phenyl]methyl][(phenylmethyl)sulfonyl]amino]-2-[(4-methylphenyl)methoxy]-, methyl ester 1919853-46-5