ChemicalBook >> CAS DataBase List >>AD80
AD80
- CAS No.
- 1384071-99-1
- Chemical Name:
- AD80
- Synonyms
- AD80;Reaxys ID: 27131146;Inhibitor,Raf,AD 80,inhibit,Raf kinases,AD-80,Ribosomal S6 Kinase (RSK),S6K,RET,AD80,Src;1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea;1-(4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-methyl-5-(trifluoromethyl)phenyl)urea;Urea, N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-
- CBNumber:
- CB03310308
- Molecular Formula:
- C22H19F4N7O
- Molecular Weight:
- 473.43
- MDL Number:
- MFCD31382193
- MOL File:
- 1384071-99-1.mol
Last updated:2023-05-18 11:31:17
| Boiling point | 530.9±50.0 °C(Predicted) |
|---|---|
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility |
DMSO:122.0(Max Conc. mg/mL);257.69(Max Conc. mM) Ethanol:94.0(Max Conc. mg/mL);198.55(Max Conc. mM) |
| pka | 12.47±0.70(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 |
AD80 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6926 | AD80 99.85% | 1384071-99-1 | 1mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-6926 | AD80 99.85% | 1384071-99-1 | 5mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-6926 | AD80 99.85% | 1384071-99-1 | 10mg | $360 | 2021-12-16 | Buy |
| ChemScene | CS-6926 | AD80 99.85% | 1384071-99-1 | 25mg | $720 | 2021-12-16 | Buy |
| ChemScene | CS-6926 | AD80 99.85% | 1384071-99-1 | 50mg | $1200 | 2021-12-16 | Buy |
AD80 Chemical Properties,Uses,Production
Biological Activity
AD80, a multi-kinase inhibitor, is more active against human RET (c-RET), BRAF, S6K, and SRC, but less active against mTOR than AD57 or AD58. Its IC50 value for RET (c-RET) is 4 nM.
in vivo
AD80 is a potent RET inhibitor with favorable pharmacokinetic profile in clinically relevant RET fusion-driven tumor models. In patient-derived xenograft species, AD80 effectively reduced RET-rearranged tumor size.
target
| Target | Value |
| Raf (Cell-free) | |
| Src < br/> (Cell-free) | |
| S6 Kinase (Cell-free) | |
| RET V804M (Cell-free assay) | 0.4 nM |
| RET V804L (Cell-free assay) | 0.6 nM |
AD80 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 65)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 16805 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
AD80
1-(4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-methyl-5-(trifluoromethyl)phenyl)urea
Urea, N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-
Reaxys ID: 27131146
1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
Inhibitor,Raf,AD 80,inhibit,Raf kinases,AD-80,Ribosomal S6 Kinase (RSK),S6K,RET,AD80,Src
1384071-99-1
C22H19F4N7O