Formononetin
- CAS No.
- 485-72-3
- Chemical Name:
- Formononetin
- Synonyms
- 7-hydroxy-3-(4-Methoxyphenyl)-4H-chroMen-4-one;ForMonentin;Formononetine;Formononetin (50 mg);Myconate;Flavosil;Mycotech;biocanin;NSC 93360;NEOCHANIN
- CBNumber:
- CB0331896
- Molecular Formula:
- C16H12O4
- Molecular Weight:
- 268.26
- MDL Number:
- MFCD00016948
- MOL File:
- 485-72-3.mol
Melting point | 256-260 °C |
---|---|
Boiling point | 331.43°C (rough estimate) |
Density | 1.1529 (rough estimate) |
vapor pressure | 0Pa at 25℃ |
refractive index | 1.4350 (estimate) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO (up to 100 mg/ml). |
form | Powder |
pka | 6.99±0.20(Predicted) |
color | White to light beige |
λmax | 300nm(EtOH)(lit.) |
Merck | 14,4244 |
BRN | 237979 |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
InChIKey | HKQYGTCOTHHOMP-UHFFFAOYSA-N |
LogP | 1.7 at 25℃ |
CAS DataBase Reference | 485-72-3(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 295DQC67BJ |
EPA Substance Registry System | 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (485-72-3) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 37/39-26-36 |
WGK Germany | 3 |
RTECS | DJ3100114 |
HS Code | 29329990 |
Formononetin price More Price(60)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 47752 | Formononetin ≥99.0% (TLC) | 485-72-3 | 5mg | $133 | 2024-03-01 | Buy |
Sigma-Aldrich | 47752 | Formononetin ≥99.0% (TLC) | 485-72-3 | 25mg | $489 | 2024-03-01 | Buy |
Sigma-Aldrich | 344215 | Formononetin A phytoestrogenic isoflavone found in soy-based foods. | 485-72-3 | 5mg | $113 | 2024-03-01 | Buy |
Sigma-Aldrich | 1286060 | Formononetin United States Pharmacopeia (USP) Reference Standard | 485-72-3 | 50mg | $1070 | 2024-03-01 | Buy |
TCI Chemical | F0868 | Formononetin >98.0%(HPLC)(T) | 485-72-3 | 1g | $133 | 2024-03-01 | Buy |
Formononetin Chemical Properties,Uses,Production
Description
Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1?Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2?Accelerates wound repair by increasing expression of Egr-1 transcription factor.3?Potential cancer chemopreventive and chemotherapeutic.4?Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5
Chemical Properties
off-white powder
Uses
An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen.
Uses
Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein . It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 μM. Formononetin has been reported to possess antitumor and antiviral activity.
Uses
Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen.
Definition
ChEBI: Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'. It has a role as a phytoestrogen and a plant metabolite. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is functionally related to a daidzein. It is a conjugate acid of a formononetin(1-).
General Description
Formononetin belongs to the isoflavones class of polyphenols.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa.
References
1) Nie?et al.?(2018),?The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol.,?175?1439 2) Gautam?et al.?(2017),?Formononetin, an isoflavone, activates AMO-activated protein kinase/?β-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit.,?117?645 3) Huh?et al. (2011),?Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol.,?11?46 4) Ong?et al.?(2019),?Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel),?11?E611 5) Li?et al.?(2018),?Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother.,?106?349
Formononetin Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 2990 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 | yklbiotech@163.com | CHINA | 296 | 58 |
View Lastest Price from Formononetin manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | Formononetin
485-72-3
|
US $0.00 / MG | 10MG | 98% HPLC | 100KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
2024-09-10 | Formononetin
485-72-3
|
US $3.00 / kg | 1kg | 0.99 | 10000 | Hebei Fengjia New Material Co., Ltd | ||
2024-06-11 | Formononetin
485-72-3
|
US $0.00-0.00 / kg | 1kg | 0.99 | 50000kg | Hebei Kingfiner Technology Development Co.Ltd |
- Formononetin
485-72-3
- US $0.00 / MG
- 98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
- Formononetin
485-72-3
- US $3.00 / kg
- 0.99
- Hebei Fengjia New Material Co., Ltd
- Formononetin
485-72-3
- US $0.00-0.00 / kg
- 0.99
- Hebei Kingfiner Technology Development Co.Ltd