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KDOAM-25

KDOAM-25 structure

CAS No.: 2230731-99-2

Chemical Name:: KDOAM-25

Synonyms: KDOAM-25;KDOAM 25,KDOAM25;KDOAM-25 trihydrochloride;4-Pyridinecarboxamide, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-

CBNumber:: CB03339897

Molecular Formula:: C15H25N5O2

Molecular Weight:: 307.39

MDL Number:: MFCD30146416

MOL File:: 2230731-99-2.mol

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KDOAM-25 Properties

Boiling point	478.6±45.0 °C(Predicted)
Density	1.137±0.06 g/cm3(Predicted)
storage temp.	-20°C
pka	15.03±0.50(Predicted)

KDOAM-25 Chemical Properties,Uses,Production

Biochem/physiol Actions

KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells.

KDOAM-25 Preparation Products And Raw materials

Raw materials

Preparation Products

KDOAM-25 Suppliers

Global( 14)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Shanghai hongqu biomedical technology co. LTD	88888888888	hongquchem@qq.com	China	5132	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3713	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10000	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23980	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Sigma-Aldrich	80
Shanghai EFE Biological Technology Co., Ltd.	58
DC Chemicals	58
Shanghai hongqu biomedical technology co. LTD	58
ShangHai ChuanQian Chemcial Technique Centre	58
cjbscvictory	58
Changzhou Furuisi Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58

KDOAM-25 4-Pyridinecarboxamide, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]- KDOAM-25 trihydrochloride KDOAM 25,KDOAM25 2230731-99-2