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KDOAM-25

CAS No.
2230731-99-2
Chemical Name:
KDOAM-25
Synonyms
KDOAM-25;KDOAM 25,KDOAM25;KDOAM-25 trihydrochloride;4-Pyridinecarboxamide, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-
CBNumber:
CB03339897
Molecular Formula:
C15H25N5O2
Molecular Weight:
307.39
MDL Number:
MFCD30146416
MOL File:
2230731-99-2.mol

KDOAM-25 Properties

Boiling point 478.6±45.0 °C(Predicted)
Density 1.137±0.06 g/cm3(Predicted)
storage temp. -20°C
pka 15.03±0.50(Predicted)

KDOAM-25 Chemical Properties,Uses,Production

Biochem/physiol Actions

KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells.

KDOAM-25 Preparation Products And Raw materials

Raw materials

Preparation Products

KDOAM-25 Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 3713 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10000 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23980 58
KDOAM-25 4-Pyridinecarboxamide, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]- KDOAM-25 trihydrochloride KDOAM 25,KDOAM25 2230731-99-2