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PF04191834

PF04191834 Structure
PF04191834 structure
CAS No.
1029317-21-2
Chemical Name:
PF04191834
Synonyms
PF-4191834;PF04191834;PF-4191834 >=98% (HPLC);PF4191834,Lipoxygenase,PF 4191834,inhibit,LOX,PF 04191834,PF-4191834,PF04191834,Inhibitor;2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]-
CBNumber:
CB03354232
Molecular Formula:
C22H23N3O2S
Molecular Weight:
393.5
MDL Number:
MOL File:
1029317-21-2.mol
Last updated:2023-05-21 10:59:17
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PF04191834 Properties

Melting point 173 °C
Boiling point 663.0±55.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 15.78±0.20(Predicted)
FDA UNII YX55DXP4T1

PF04191834 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0063590 PF-4191834 ≥99.0% 1029317-21-2 5mg $690 2021-12-16 Buy
Product number Packaging Price Buy
CS-0063590 5mg $690 Buy

PF04191834 Chemical Properties,Uses,Production

Biological Activity

PF-4191834 (PF-04191834) is an orally active, non-iron-chelating, non-redox 5-lipoxygenase (5-LOX) inhibitor (IC50=229 nM), 5-LOX is about 300 times more selective than 12-LOX and 15-LOX, has no activity against cyclooxygenase, and is effective against inflammation and pain.

in vitro

PF-4191834 (PF-04191834) inhibits the synthesis of the 5-LOX products 5-HETE, 5-oxo-ETE, LTB4, and LTE4 with estimated IC 50 values between 100 and 190 nM and do not inhibit significantly the COX-1/2 enzymes or the 12- or 15-LOX enzymes at concentrations up to 30 μM. PF-4191834 (PF-04191834) exerts a concentration-dependent inhibition of human 5-LOX, with an IC 50 value of 130 nM and an IC 80 value of 370 nM.

target

5-LOX

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PF04191834 Preparation Products And Raw materials

Raw materials

Preparation Products

PF04191834 Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3421 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29797 68
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44894 58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd 1701086315 dexuanpharma@126.com China 9478 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223 psaitong@jm-bio.com China 29834 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29989 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5019 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Energy Chemical 58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
https://hanhongsci.com/ 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58

1029317-21-2(PF04191834)Related Search:

PF-06372222 PF-232798 PF-68742 PF-06882961
PF04191834 PF-4191834 2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]- PF-4191834 >=98% (HPLC) PF4191834,Lipoxygenase,PF 4191834,inhibit,LOX,PF 04191834,PF-4191834,PF04191834,Inhibitor 1029317-21-2