BPV(PIC)
- CAS No.
- 148556-27-8
- Chemical Name:
- BPV(PIC)
- Synonyms
- BPV(PIC);K2 [VO(O2)2C6H4NO2] 2 H2O;bpV(pic) (potassium hydrate);Dipotassium Bisperoxovanadium(pic) dihydrate;DIPOTASSIUM BISPEROXO(PICOLINATO)OXOVANADATE (V);Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate
- CBNumber:
- CB0345392
- Molecular Formula:
- C6H8K2NO9V-3
- Molecular Weight:
- 367.26712
- MDL Number:
- MFCD01865948
- MOL File:
- 148556-27-8.mol
- MSDS File:
- SDS
BPV(PIC) price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0885 | bpV(pic) ≥95% V basis | 148556-27-8 | 5mg | $104 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0885 | bpV(pic) ≥95% V basis | 148556-27-8 | 25mg | $167.6 | 2024-03-01 | Buy |
| Cayman Chemical | 14434 | bpV(pic) (potassium hydrate) ≥96% | 148556-27-8 | 5mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 14434 | bpV(pic) (potassium hydrate) ≥96% | 148556-27-8 | 25mg | $330 | 2024-03-01 | Buy |
| TRC | V785033 | bpV(pic) | 148556-27-8 | 5mg | $70 | 2021-12-16 | Buy |
BPV(PIC) Chemical Properties,Uses,Production
Uses
bpV(pic) is a potent protein PTP inhibitor.
Uses
bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 12.7 μM), and PTP-1βB (IC50 = 61 μM). bpV(pic) is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells, stimulating lipogenesis in adipocytes, and inhibiting the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes.
Biochem/physiol Actions
bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).
BPV(PIC) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| Sigma-Aldrich | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| Energy Chemical | 58 |