5-HYDROXYINDOLE-3-ACETIC ACID
- CAS No.
- 54-16-0
- Chemical Name:
- 5-HYDROXYINDOLE-3-ACETIC ACID
- Synonyms
- 5-HIAA;HIAA;2-(5-hydroxy-1H-indol-3-yl)acetic acid;5-oxyindoleaceticacid;5-HYDROXY-3-INDOLEACETIC ACID;5'5-HO-IAA;NSC 90432;Nature Product;TIMTEC-BB SBB003639
- CBNumber:
- CB0362913
- Molecular Formula:
- C10H9NO3
- Molecular Weight:
- 191.18
- MDL Number:
- MFCD00005639
- MOL File:
- 54-16-0.mol
- MSDS File:
- SDS
Melting point | 161-164 °C (dec.) (lit.) |
---|---|
Boiling point | 326.92°C (rough estimate) |
Density | 1.2722 (rough estimate) |
refractive index | 1.5310 (estimate) |
storage temp. | -20°C |
solubility | Soluble in ethanol (50 mg/ml). |
pka | 4.54±0.30(Predicted) |
form | crystalline |
color | off-white to purple |
Sensitive | Light Sensitive |
BRN | 168797 |
Stability | Air Sensitive, Light Sensitive |
InChIKey | DUUGKQCEGZLZNO-UHFFFAOYSA-N |
CAS DataBase Reference | 54-16-0 |
EWG's Food Scores | 1 |
NCI Dictionary of Cancer Terms | 5-hydroxyindoleacetic acid |
FDA UNII | YHC763JY1P |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P271-P280 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | NL3650000 | |||||||||
F | 8-10-23 | |||||||||
HS Code | 29339980 | |||||||||
NFPA 704 |
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5-HYDROXYINDOLE-3-ACETIC ACID price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | H8876 | 5-Hydroxyindole-3-acetic acid ≥98% (HPLC), crystalline | 54-16-0 | 100mg | $36.1 | 2024-03-01 | Buy |
Sigma-Aldrich | H8876 | 5-Hydroxyindole-3-acetic acid ≥98% (HPLC), crystalline | 54-16-0 | 1g | $178 | 2024-03-01 | Buy |
TCI Chemical | H0355 | 5-Hydroxyindole-3-acetic Acid >98.0%(HPLC)(T) | 54-16-0 | 1g | $320 | 2024-03-01 | Buy |
TCI Chemical | H0355 | 5-Hydroxyindole-3-acetic Acid >98.0%(HPLC)(T) | 54-16-0 | 100mg | $43 | 2024-03-01 | Buy |
Alfa Aesar | J61435 | 5-Hydroxyindole-3-acetic acid, 98% | 54-16-0 | 500mg | $77.65 | 2024-03-01 | Buy |
5-HYDROXYINDOLE-3-ACETIC ACID Chemical Properties,Uses,Production
Description
5-hydroxy Indole-3-acetic acid (5-HIAA) is the primary metabolite of serotonin (5-HT; ). It is formed when 5-HT is metabolized by monamine oxidase and aldehyde dehydrogenase in the liver. 5-HIAA is excreted in urine and has been used as a biomarker for detection of neuroendocrine tumors and an internal standard for the quantification of serotonin metabolism in rat brain using mass spectrometry. 5-HIAA has also been associated with autism, insomnia, and chronic migraine.
Chemical Properties
beige crystalline powder
Uses
5-Hydroxyindole-3-acetic acid is a major serotonin metabolite.
Uses
5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.
Definition
ChEBI: A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
General Description
5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway. 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients. Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF. 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).
Mechanism of action
The primary product of the metabolism of serotonin. Formed by the oxidative deamination of serotonin by monoamine oxidase, presumably the A isozyme, 5-HIAA is subsequently cleared by an active transport mechanism. Unlike serotonin, 5-HIAA is not a neurotransmitter and thus its formation contributes to the termination of the synaptic actions of serotonin. Inhibition of monoamine oxidase activity enhances and prolongs the actions of serotonin.
5-HYDROXYINDOLE-3-ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9354 | 55 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
View Lastest Price from 5-HYDROXYINDOLE-3-ACETIC ACID manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-02-17 | (5-hydroxyindol-3-yl)acetic acid
54-16-0
|
US $1.00 / KG | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
- (5-hydroxyindol-3-yl)acetic acid
54-16-0
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co
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