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(1R)-(-)-10-Camphorsulfonic acid

L-Camphorsulfonic acid Chemical properties Uses Production method
(1R)-(-)-10-Camphorsulfonic acid
(1R)-(-)-10-Camphorsulfonic acid structure
CAS No.
35963-20-3
Chemical Name:
(1R)-(-)-10-Camphorsulfonic acid
Synonyms
(-)-10-CSA;(-)-CamphorsuL;L(-)-Camphorsulfonic;Camphor-sulphonicacid;L-CAMPHORSULPHONIC ACID;CLOPIDOGREL INTERMEDIATES;L-(-)-CAMPHORSULFONIC ACID;L(+)-CAMPHORSULPHONIC ACID;S-(-)-CAMPHORSULFONIC ACID;(-)-10-CAMPHORSULFONIC ACID
CBNumber:
CB0365888
Molecular Formula:
C10H16O4S
Formula Weight:
232.3
MOL File:
35963-20-3.mol

(1R)-(-)-10-Camphorsulfonic acid Properties

Melting point:
198 °C (dec.)(lit.)
alpha 
-22 º (c=20,H2O)
Boiling point:
344.46°C (rough estimate)
Density 
1.2981 (rough estimate)
refractive index 
-21.5 ° (C=5, H2O)
storage temp. 
2-8°C
pka
1.17±0.50(Predicted)
form 
Crystalline Powder
color 
White to slightly beige
PH
1.2-1.4 (20g/l, H2O)
optical activity
[α]20/D 21°, c = 2 in H2O
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
2809676
Stability:
Stable. Hygroscopic. Incompatible with strong bases, strong oxidizing agents.
InChIKey
MIOPJNTWMNEORI-XVKPBYJWSA-N
CAS DataBase Reference
35963-20-3(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H290-H318-H314
Precautionary statements  P280-P305+P351+P338-P310-P234-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501-P260h-P301+P330+P331-P303+P361+P353-P501a
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45-24/25-27
RIDADR  UN 3261 8/PG 2
WGK Germany  3
3-10
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29147090
NFPA 704
0
3 0

(1R)-(-)-10-Camphorsulfonic acid price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 21365 (?)-Camphor-10-sulfonic acid purum, ≥98.0% (T) 35963-20-3 50g-f $76.4 2020-08-18 Buy
Sigma-Aldrich 21365 (?)-Camphor-10-sulfonic acid purum, ≥98.0% (T) 35963-20-3 250g-f $265 2020-08-18 Buy
TCI Chemical C0972 (-)-10-Camphorsulfonic Acid >98.0%(T) 35963-20-3 25g $20 2020-06-24 Buy
TCI Chemical C0972 (-)-10-Camphorsulfonic Acid >98.0%(T) 35963-20-3 100g $56 2020-06-24 Buy
Alfa Aesar B21553 (1R)-(-)-Camphor-10-sulfonic acid, 98+% 35963-20-3 25g $39.7 2020-06-24 Buy

(1R)-(-)-10-Camphorsulfonic acid Chemical Properties,Uses,Production

L-Camphorsulfonic acid

Camphor sulfonic acid includes L-camphor sulfonic acid, D-camphor sulfonic acid and racemic camphor sulfonic acid these three isomers.
It is a kind of white columnar crystals with the melting point of 193°C (decomposition). [α]D20+24° (water). It is Slightly soluble in ethanol, insoluble in ether, soluble in sodium hydroxide and sodium carbonate solution. L-camphor sulfonic acid could be produced from reaction between camphor, sulfuric acid and acetic anhydride.It has a lot of functions such as exciting the respiratory center, the vascular movement center and myocardium. Its sodium salt plays pharmaceutical role in medicine.
Camphor sulfonic acid sodium salt is a kind of white crystalline powder. It is odorless and tastes bitter and then sweet. It is easily absorb moisture and easily dissolve in the water and hot ethanol. So it should be shading confined preservation. it can Directly excite the medulla oblongata respiratory center and vascular movement center, and quicken and deepen the breath, rise the blood pressure; it also can directly excite the myocardium and strength the contraction of cardiac muscle as well as could increase the output.
It is applied the treatment of infectious disease, as well as the disease like central inhibition of poisoning caused by respiratory depression, fatigue, high fever, poisoning, heat stroke and other acute heart failure.

Chemical properties

It is a kind of prismatic crystals and its melting point is 193-195 ° C (decompose). It is Insoluble in ether and slightly soluble in glacial acetic acid and ethyl acetate. And it is and moisture in wet air.

Uses

(1) It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.

Production method

Camphor sulfonic acid is obtained from camphor and sulfuric acid by irradiation.
This method involves:
1) Adding the camphor and acetic anhydride to the pot.
2) Mixing it and making it dissolved.
3) Dripping sulfuric acid after cooling. And the reaction should be maintained at 44-45 °C for 48 hours. Then cool it to 6-7 °C.
4) Crystallizing, filtrating, washing with a small amount of acetic acid crystals, and dry it to get camphor sulfonic acid.

Chemical Properties

white to light yellow crystal powde

Uses

1R)-(-)-10-Camphorsulfonic acid is a chiral derivative of Camphor.It has the following uses:
(1)It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.

Definition

ChEBI: The R enantiomer of camphorsulfonic acid.

Purification Methods

It forms prisms from AcOH or EtOAc, and is deliquescent in moist air. Store it in tightly stoppered bottles. The NH4 salt forms needles from H2O [] D ±20.5o (c 5, H2O). [Burgess & Lowry J Chem Soc 127 279 1925, Marsi et al. J Am Chem Soc [ 78 3063 1956.] The RS-acid recrystallises from AcOH. [60g of (±)-acid in 60mL of AcOH at 105o gave 40g of crystals has m 202-203o [Bartlett & Knox Org Synth 45 12 1965.] [Beilstein 11 IV 642.]

(1R)-(-)-10-Camphorsulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products


(1R)-(-)-10-Camphorsulfonic acid Suppliers

Global( 365)Suppliers
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Hubei Jusheng Technology Co.,Ltd.
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Xiamen AmoyChem Co., Ltd
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View Lastest Price from (1R)-(-)-10-Camphorsulfonic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-25 L(-)Camphor Sulfonic Acid
35963-20-3
US $100.00-90.00 / KG 1KG 99% 100kg/month or Customized career henan chemical co

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