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Roscovitine

Roscovitine Structure
Roscovitine structure
CAS No.
186692-46-6
Chemical Name:
Roscovitine
Synonyms
Seliciclib;Roscovitin;Roscovitine (Seliciclib,CYC202);CYC 202;Posiphe;CS-1845;P34 CDC2;ROSCOVITINE;Roscoviline;(R)-2-(1-ETHY
CBNumber:
CB0367185
Molecular Formula:
C19H26N6O
Molecular Weight:
354.45
MDL Number:
MFCD02266401
MOL File:
186692-46-6.mol
MSDS File:
SDS
Last updated:2024-04-17 09:15:14
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Roscovitine Properties

Melting point 106～107℃
Boiling point 577.5±60.0 °C(Predicted)
Density 1.3
storage temp. -20°C
solubility Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).
form White to off-white solid
pka 14.56±0.10(Predicted)
color White
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey BTIHMVBBUGXLCJ-OAHLLOKOSA-N
CAS DataBase Reference 186692-46-6(CAS DataBase Reference)
FDA UNII 0ES1C2KQ94
NCI Drug Dictionary seliciclib

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312
Safety Statements  22-24/25
WGK Germany  3
HS Code  29335990

Roscovitine price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 557360 Roscovitine 186692-46-6 1mg $71.1 2024-03-01 Buy
Sigma-Aldrich 557360 Roscovitine 186692-46-6 5mg $259 2024-03-01 Buy
Cayman Chemical 10009569 (R)-Roscovitine ≥98% 186692-46-6 500μg $22 2024-03-01 Buy
Cayman Chemical 10009569 (R)-Roscovitine ≥98% 186692-46-6 1mg $40 2024-03-01 Buy
Sigma-Aldrich R7772 Roscovitine ≥98% (TLC) 186692-46-6 1mg $66.6 2024-03-01 Buy
Product number Packaging Price Buy
557360 1mg $71.1 Buy
557360 5mg $259 Buy
10009569 500μg $22 Buy
10009569 1mg $40 Buy
R7772 1mg $66.6 Buy

Roscovitine Chemical Properties,Uses,Production

Description

Roscovitine (186692-46-6) is a potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine. ?p34 cdc2 IC50 = 0.2 μM.? Also inhibits p33cdk2 and p33cdk5.1? Anti-angiogenic.2 Prevents PPARg S273 phosphorylation, promoting browning of white adipose tissue.3 Enhances peripheral nerve regrowth.4

Uses

Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). Roscovitine has been found to produce apoptosis in treated cancerous cells of non-small cell lung cancer (NSCLC) and other cancers. Studies show that Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. Roscovitine maybe useful in the treatment of non-small cell lung cancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation disorders.

Definition

ChEBI: 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.

General Description

A potent, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks) that exhibits about ten-fold greater efficacy towards p34cdk1 and p33cdk2 and twenty-fold greater efficacy towards p33cdk5 relative to Olomoucine (Cat. No. 495620). Inhibits p34cdk1/cyclin B (IC50 = 650 nM), p33cdk2/cyclin A (IC50 = 700 nM), p33cdk2/cyclin E (IC50 = 700 nM), and p33cdk5/p35 (IC50 = 200 nM) by competing for the ATP binding domain of the kinases. Exhibits reduced sensitivity towards related kinases including ERK1 and ERK2 (IC50 = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM, including p34cdk4/cyclin D1 and p40cdk6/cyclin D2. Compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. A 50 mM (5 mg/282 μl) solution of Roscovitine (Cat. No. 557364) in DMSO is also available.

Biochem/physiol Actions

Roscovitine is a purine derived inhibitor. It stimulates apoptosis in cancer cells. It has inhibitory action on mitogen activated protein kinase (MAPK) and M-phase promoting factor (MPF) kinase activity. Roscovitine is known to arrest meiosis and thus, prevent embryonic development.

Anticancer Research

Roscovitine a derivative of olomoucine which is isolated from Raphanus sativus isunder clinical trials (Shoeb 2006).

storage

Store at -20°C

References

1) Meijer et al. (1997), Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5 ; Eur. J. Biochem., 243 527 2) Liebl et al. (2011), Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases; Angiogenesis, 14 281 3) Wang et al. (2016) Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1+ Adipocytes; Cell Metab. 24 835 4) Law et al. (2016) Enhancement of Peripheral Nerve Regrowth by the Purine Nucleoside Analog and Cell Cycle Inhibitor, Roscovitine; Front. Cell. Neurosci. 10 238

Roscovitine Preparation Products And Raw materials

Raw materials

Preparation Products

Roscovitine Suppliers

Global( 212)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shanghai Gubang New Materail Technology Co. LTD 		21-51317962 +8618721305404 16728589@qq.com CHINA 272 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Supplier Advantage
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
Hubei xin bonus chemical co. LTD 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Shanghai Gubang New Materail Technology Co. LTD 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58

Related articles

View Lastest Price from Roscovitine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ROSCOVITINE pictures 2023-03-24 ROSCOVITINE
186692-46-6
 US $50.00 / kg 1kg 99% 20 tons Hebei Duling International Trade Co. LTD
ROSCOVITINE pictures 2021-08-12 ROSCOVITINE
186692-46-6
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
ROSCOVITINE pictures 2019-09-06 ROSCOVITINE
186692-46-6
 US $1.00 / KG 1KG 98% 20kg Career Henan Chemical Co
  • ROSCOVITINE pictures
  • ROSCOVITINE
    186692-46-6
  • US $50.00 / kg
  • 99%
  • Hebei Duling International Trade Co. LTD
  • ROSCOVITINE pictures
  • ROSCOVITINE
    186692-46-6
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • ROSCOVITINE pictures
  • ROSCOVITINE
    186692-46-6
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co

Roscovitine Spectrum

ROSCOVITINE(186692-46-6)1HNMR

186692-46-6(Roscovitine)Related Search:

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Selumetinib Alisertib (MLN8237) Dasatinib PD 0332991 HCl
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol PD0332991 Isethionate BML-259 NS-398 Roscovitine
SELICICLIB (S)-ROSCOVITINE S-ROSCOVITINE 98% (HPLC),ROSCOVITINE, (S)-ISOMER,(S)-ROSCOVITINE RS-ROSCOVITINE 98% (HPLC) (R)-ROSCOVITINE, >95%
ROSCOVITINE, IMMOBILIZED OLOMOUCINE II ROSCOVITINE, 99+%

1of4

2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine (2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol 2-(R)-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE 2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE 6-BENZYLAMINO-2-(R)-[(1-ETHYL)-2-HYDROXYETHYLAMINO]-9-ISOPROPYLPURINE ROSCOVITINE (R)-ROSCOVITINE (R)-2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE P34 CDC2 R-ROSCOVITINE 98% (HPLC) ROSCOVITINE 95+% 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)- 2-(r)-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9h-purin-2-yl]amino]-1-butanol 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine (CYC202,Seliciclib) 6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine Roscovitine Roscovitine,2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine(CYC202) 2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]- (R)-2-(1-ETHY Roscovitine (Seliciclib) (2R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol (R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol CYC 202 Roscoviline Posiphe CYC-202(ROSCOVITINE) 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine (Seliciclib,CYC202) Roscovitine (R)-Roscovitine Roscovitine, >=98% Roscovitine - CAS 186692-46-6 - Calbiochem CS-1845 SELICICLIB (ROSCOVITINE) CYC202;R-ROSCOVITINE;SELICICLIB 2-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol （CYC202) ROSCOVITINE USP/EP/BP Seliciclib-d7 Seliciclib Roscovitin Roscovitine (Seliciclib,CYC202) 186692-46-6 Cell Signaling and Neuroscience Cell Cycle Cell Cycle Regulators Cell Biology BioChemical Apoptosis and Cell Cycle Inhibitors Apis API intermediates