ChemicalBook >> CAS DataBase List >>N-Benzyloxycarbonyl-L-proline
N-Benzyloxycarbonyl-L-proline
- CAS No.
- 1148-11-4
- Chemical Name:
- N-Benzyloxycarbonyl-L-proline
- Synonyms
- Z-Pro;Z-PRO-OH;CBZ-PRO-OH;Z-L-PRO-OH;N-CBZ-L-PROLINE;CBZ-L-Pro-OH;CARBOBENZYLOXY-L-PROLINE;N-CARBOBENZYLOXY-L-PROLINE;(S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid;Z-PROLINE
- CBNumber:
- CB0370381
- Molecular Formula:
- C13H15NO4
- Molecular Weight:
- 249.26
- MDL Number:
- MFCD00003170
- MOL File:
- 1148-11-4.mol
- MSDS File:
- SDS
Last updated:2024-01-02 16:51:54
| Melting point | 75-77 °C |
|---|---|
| alpha | -60 º (c=2,AcOH) |
| Boiling point | 392.36°C (rough estimate) |
| Density | 1.1952 (rough estimate) |
| refractive index | -40 ° (C=2, EtOH) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Solubility in methanol, almost transparency. |
| form | Crystalline Powder or Crystals |
| pka | 3.99±0.20(Predicted) |
| color | White to off-white |
| optical activity | [α]20/D 42°, c = 2 in ethanol |
| BRN | 88579 |
| InChIKey | JXGVXCZADZNAMJ-NSHDSACASA-N |
| CAS DataBase Reference | 1148-11-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | H2BS8M5FPP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318 | |||||||||
| Precautionary statements | P271-P261-P280 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 62-36/37/38-20/21/22 | |||||||||
| Safety Statements | 22-24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UY0745000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
N-Benzyloxycarbonyl-L-proline price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C8601 | Z-Pro-OH 99% | 1148-11-4 | 10g | $88.8 | 2024-03-01 | Buy |
| TCI Chemical | C0713 | N-Carbobenzoxy-L-proline >98.0%(HPLC)(T) | 1148-11-4 | 5g | $17 | 2024-03-01 | Buy |
| TCI Chemical | C0713 | N-Carbobenzoxy-L-proline >98.0%(HPLC)(T) | 1148-11-4 | 25g | $33 | 2024-03-01 | Buy |
| Alfa Aesar | B21672 | N-Benzyloxycarbonyl-L-proline, 98+% | 1148-11-4 | 5g | $28.65 | 2024-03-01 | Buy |
| Alfa Aesar | B21672 | N-Benzyloxycarbonyl-L-proline, 98+% | 1148-11-4 | 50g | $141.65 | 2024-03-01 | Buy |
N-Benzyloxycarbonyl-L-proline Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
N-(Benzyloxycarbonyl)-L-proline is a potent in vitro and in vivo inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. It is also used in the synthesis of N-(L-Prolyl)-β-alanine which is a derivative of the naturally occurring beta amino acid β-Alanine.
Preparation
Caution! All procedures must be carried out in an efficient fume cupboard, wearing latex gloves and chemical-proof safety goggles. ι-Proline (10.0 g, 8.7 mmol) was dissolved in 2 m sodium hydroxide solution (40 mL), and the solution was cooled to ice-water temperature. Z-Cl (20.5 g, 12 mmol) was added portionwise, with vigorous stirring or occasional shaking, over a period of 30 min at 0–5 °C to the solution of l-proline. The ice bath was then removed and stirring or occasional shaking was continued for 30 min while the reaction mixture warmed to room temperature. The mixture was then acidified to Congo red by the gradual addition of concentrated hydrochloric acid, and the oil was extracted into ethyl acetate. The extract was dried over magnesium sulfate, the mixture was filtered, and the filtrate was concentrated in vacuo. The residue was extracted/triturated with warm tetrachloromethane. The washings were decanted and the residue was further purified by recrystallization from ethyl acetate/petroleum ether.
N-Benzyloxycarbonyl-L-proline Preparation Products And Raw materials
Global( 504)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-028-64841719 +8618980456393 | daisy@enlaibio.com | China | 1369 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2531 | 58 |
View Lastest Price from N-Benzyloxycarbonyl-L-proline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | Cbz-L-Pro-OH
1148-11-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1T | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2024-01-02 | Z-Pro-OH
1148-11-4
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-12-24 | N-Benzyloxycarbonyl-L-proline
1148-11-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd |
-
- Cbz-L-Pro-OH
1148-11-4
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Z-Pro-OH
1148-11-4
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- N-Benzyloxycarbonyl-L-proline
1148-11-4
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
1148-11-4(N-Benzyloxycarbonyl-L-proline)Related Search:
n-benzyloxycarbonylproline
N-Benzyloxycarbonyl-L-proline~Z-Pro-OH
N-cbz-L-proline crystalline
N-CBZ-L-Proline N-Carbobenzyloxy-L-proline
N-Cbz-L-Pro-OH
carbobenzoxyproline
N-Benzyloxycarbonyl-L-proline, 98+%
L-Cbz-ProlineN
Z-L-PROLINE extrapure
N-Cbz-L-proline, 98+%
1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L-
N-[(Phenylmethoxy)carbonyl]-L-proline
N-Benzyloxycarbonyl-(S)-proline
(2S)-1,2-Pyrrolidinedicarboxylic acid 1-benzyl ester
(2S)-1,2-Pyrrolidinedicarboxylic acid hydrogen 1-benzyl ester
N-Carbobenzyloxy-L-proline,99%
(2S)-Pyrrolidine-2-carboxylic acid, N-CBZ protected
L-Proline, N-CBZ protected, (2S)-1-[(Benzyloxy)carbonyl]pyrrolidine-2-carboxylic acid
N-Carbobenzyloxy-L-proline, 99% 10GR
N-Cbz-L-proline
Z-Pro-OH
(2S)-1-[(benzyloxy)carbonyl]-2-pyrrolidinecarboxylic acid
(S)-N-Benzyloxycarbonyl-L-proline
1-benzylester,l-2-pyrrolidinedicarboxylicacid
benzyloxycarbonylproline
carbobenzoxy-l-proline
carbobenzoxy-s-proline
Z-Pro-OH 99%
l-1,2-pyrrolidinedicarboxylicacid1-benzylester
1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)-
1-[oxo-(phenylmethoxy)methyl]-2-pyrrolidinecarboxylic acid
(S)-Z-pyrrolidine-2-carboxylic acid
Z-L-proline≥ 99% (HPLC)
1-[(BENZYLOXY)CARBONYL]-L-PROLINE
1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL) ESTER, (2S)-
(2S)-1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID
CBZ-L-PROLINE
L-CBZ-PROLINE
BENZYLOXYCARBONYL-L-PROLINE
(S)-N-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID
N-ALPHA-BENZYLOXYCARBONYL-L-PROLINE
N-BENZYLOXYCARBONYL-L-PROLINE
N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID
N-ALPHA-CARBOBENZOXY-L-PROLINE
N-ALPHA-CBZ-L-PROLINE
N-CBZ-L-PROLINE-OH
N-CARBOBENZOXY-L-PROLINE
Z-PROLINE
Z-PYRD(2)-OH
1-(phenylmethyl)ester,(s)-2-pyrrolidinedicarboxylicacid
N-Carbobenzoxy-L-proline >
(2S)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylicaci
N-Benzyloxycarbonyl-L-proline USP/EP/BP
N-BENZYLOXYCARBONY-L-PROLIN
TIANFU CHEM N-Benzyloxycarbonyl-L-proline
Fmoc-Thr(Ac?AcNH-α-Gal)-OH
ZINC77292789
CBZ-L-Pro-OH
(S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid