Hydrocortisone sodium succinate
- CAS No.
- 125-04-2
- Chemical Name:
- Hydrocortisone sodium succinate
- Synonyms
- solu-cortef;PREGN-4-ENE-3 20-DIONE 21-(3-CARBOXY-1-O XOPROPOXY)-11 17-DIHYDROXY-MONOSODIUM SA LT (11)-CORTISOL 21-(SODIUM SUCCINATE);u4905;corlan;Cortop;hycorace;oralsone;Arcocort;intracort;nordicort
- CBNumber:
- CB0373175
- Molecular Formula:
- C25H33O8.Na
- Molecular Weight:
- 484.52
- MDL Number:
- MFCD00069472
- MOL File:
- 125-04-2.mol
| Melting point | 169.0-171.2° |
|---|---|
| storage temp. | −20°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | White to Off-White |
| InChIKey | HHZQLQREDATOBM-CODXZCKSSA-M |
| CAS DataBase Reference | 125-04-2(CAS DataBase Reference) |
| FDA UNII | 50LQB69S1Z |
| NCI Drug Dictionary | A-Hydrocort |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361d |
| Precautionary statements | P201-P308+P313 |
| WGK Germany | 3 |
| RTECS | GM9015000 |
Hydrocortisone sodium succinate price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H4881 | Hydrocortisone 21-hemisuccinate sodium salt ≥90% (HPLC) | 125-04-2 | 1g | $182 | 2024-03-01 | Buy |
| Sigma-Aldrich | H2270 | Hydrocortisone 21-hemisuccinate sodium salt powder, BioReagent, suitable for cell culture | 125-04-2 | 100mg | $43.4 | 2024-03-01 | Buy |
| Cayman Chemical | 18226 | Hydrocortisone 21-hemisuccinate (sodium salt) ≥98% | 125-04-2 | 100mg | $30 | 2024-03-01 | Buy |
| Cayman Chemical | 18226 | Hydrocortisone 21-hemisuccinate (sodium salt) ≥98% | 125-04-2 | 1g | $178 | 2024-03-01 | Buy |
| Sigma-Aldrich | H4881 | Hydrocortisone 21-hemisuccinate sodium salt ≥90% (HPLC) | 125-04-2 | 100mg | $36.3 | 2024-03-01 | Buy |
Hydrocortisone sodium succinate Chemical Properties,Uses,Production
Uses
Hydrocortisone Hemisuccinate Sodium is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone Hemisuccinate Sodium is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.
Uses
Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 μM for IL-6). It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.
Uses
Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone sodium succinate is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.
Definition
ChEBI: Hydrocortisone Sodium Succinate is an organic molecular entity.
brand name
A-Hydrocort (Abbott); A-Hydrocort (Hospira); Solu-Cortef (Pharmacia & Upjohn).
General Description
Hydrocortisone for use in epithelial and endothelial adherent cell culture applications.
Drug interactions
Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifampicin;
metabolism possibly inhibited by erythromycin;
concentration of isoniazid possibly reduced.
Anticoagulants: efficacy of coumarins and
phenindione may be altered.
Antiepileptics: metabolism accelerated by
carbamazepine, fosphenytoin, phenobarbital,
phenytoin and primidone.
Antifungals: increased risk of hypokalaemia with
amphotericin - avoid; metabolism possibly inhibited
by itraconazole and ketoconazole.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: rare reports of convulsions in patients
on ciclosporin and high-dose corticosteroids.
Cobicistat: concentration of hydrocortisone possibly
increased - increased risk of adrenal suppression.
Diuretics: enhanced hypokalaemic effects of
acetazolamide, loop diuretics and thiazide diuretics.
Vaccines: high dose corticosteroids can impair
immune response to vaccines - avoid concomitant
use with live vaccines.
Metabolism
Hydrocortisone is metabolised in the liver and most body tissues to hydrogenated and degraded forms such as tetrahydrocortisone and tetrahydrocortisol. These are excreted in the urine, mainly conjugated as glucuronides, with a very small proportion of unchanged hydrocortisone.
Hydrocortisone sodium succinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12457 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Hydrocortisone sodium succinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-14 | Hydrocortisone sodium succinate
125-04-2
|
US $0.00 / kg | 1kg | 99% | 1000tons | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-03-28 | Hydrocortisone sodium succinate
125-04-2
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2021-09-29 | Hydrocortisone sodium succinate
125-04-2
|
US $1.00 / Kg/Bag | 100g | 97.0%~102.0%,USP41 | 200kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Hydrocortisone sodium succinate
125-04-2
- US $0.00 / kg
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Hydrocortisone sodium succinate
125-04-2
- US $10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- Hydrocortisone sodium succinate
125-04-2
- US $1.00 / Kg/Bag
- 97.0%~102.0%,USP41
- WUHAN FORTUNA CHEMICAL CO., LTD