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trans-1,2-Cyclohexanedicarboxylic acid

trans-1,2-Cyclohexanedicarboxylic acid
trans-1,2-Cyclohexanedicarboxylic acid structure
CAS No.
2305-32-0
Chemical Name:
trans-1,2-Cyclohexanedicarboxylic acid
Synonyms
Lura;trans-CycL;REMAINDER CIS;ohexane-1,2-dicarboxyL;Lurasidone InterMediate(1);1,2-cyclohexanedicarboxylic;TRANS-HEXAHYDRO-PHTHALIC ACID;rans-1,2-Cyclohexanedicarboxylicaci;Trans-1,2-cyclohexane carboxylic acid;TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACDI
CBNumber:
CB0376262
Molecular Formula:
C8H12O4
Formula Weight:
172.18
MOL File:
2305-32-0.mol

trans-1,2-Cyclohexanedicarboxylic acid Properties

Melting point:
228-230 °C (lit.)
Boiling point:
262.49°C (rough estimate)
Density 
1.2104 (rough estimate)
refractive index 
1.4450 (estimate)
storage temp. 
Store below +30°C.
pka
pK1:4.18;pK2: 5.93 (20°C)
Water Solubility 
2g/L(20 ºC)
BRN 
3200609
InChIKey
QSAWQNUELGIYBC-WDSKDSINSA-N
CAS DataBase Reference
2305-32-0(CAS DataBase Reference)
NIST Chemistry Reference
1,2-Cyclohexanedicarboxylic acid, trans-(2305-32-0)
EPA Substance Registry System
1,2-Cyclohexanedicarboxylic acid, (1R,2R)-rel- (2305-32-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  GU9065000
TSCA  Yes
HS Code  29172000

trans-1,2-Cyclohexanedicarboxylic acid price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 147516 trans-1,2-Cyclohexanedicarboxylic acid 95% 2305-32-0 5g $97.8 2021-12-16 Buy
Sigma-Aldrich 8.41088 trans-Cyclohexane-1,2-dicarboxylic acid for synthesis 2305-32-0 5 g $106.37 2021-12-16 Buy
Sigma-Aldrich 147516 trans-1,2-Cyclohexanedicarboxylic acid 95% 2305-32-0 25g $264 2021-12-16 Buy
TCI Chemical C0474 trans-1,2-Cyclohexanedicarboxylic Acid >98.0%(GC)(T) 2305-32-0 25g $108 2021-12-16 Buy
TCI Chemical C0474 trans-1,2-Cyclohexanedicarboxylic Acid >98.0%(GC)(T) 2305-32-0 500g $1028 2021-12-16 Buy

trans-1,2-Cyclohexanedicarboxylic acid Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

trans-1,2-cyclohexanedicarboxylic acid be used as organic intermediates.

Uses

trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.

Purification Methods

It is purified by recrystallisation from EtOH or H2O. It is formed by hydrolyzing the anhydride with water. The dimethyl ester has m 95-96o (from *C6H6/pet ether). [Abell J Org Chem 22 769 1957, Smith & Byrne J Am Chem Soc 72 4406 1950, Linstead et al. J Am Chem Soc 64 2093 1942, Beilstein 9 III 3812, 9 IV 2801.] The 1R,2R-(-)-trans-cyclohexane-1,2-acid [46022-05-3] has m 171-182o and [ ] D -20o (c 1, Me2CO). cis-Cyclohexane-1,2-dicarboxylic anhydride (cis-hexahydrophthalic anhydride) [85-42-7, 13149-00-3] M 154.2, m 32-34o, b 158o/17mm. It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.]

trans-1,2-Cyclohexanedicarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products


trans-1,2-Cyclohexanedicarboxylic acid Suppliers

Global( 225)Suppliers
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Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
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Henan DaKen Chemical CO.,LTD.
+86-371-66670886
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Henan Tianfu Chemical Co.,Ltd.
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career henan chemical co
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Jinan Jianfeng Chemical Co., Ltd
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0531-88113608 info@pharmachemm.com CHINA 200 58
Jinan Finer Chemical Co., Ltd
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Accela ChemBio Inc.
(+1)-858-699-3322
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Hebei Guanlang Biotechnology Co., Ltd.
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sales3@crovellbio.com China 5942 58
Xiamen AmoyChem Co., Ltd
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sales@amoychem.com CHINA 6369 58
Shochem(Shanghai) Co.,Ltd
86-21-50800795
info@shochem.com CHINA 289 58

View Lastest Price from trans-1,2-Cyclohexanedicarboxylic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-12 trans-1,2-Cyclohexanedicarboxylic acid
2305-32-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-06-16 trans-1,2-Cyclohexanedicarboxylic acid
2305-32-0
US $1.00 / PCS 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-07-06 trans-1,2-Cyclohexanedicarboxylic acid
2305-32-0
US $1.00 / kg 1g 99% 100KG Career Henan Chemical Co

trans-1,2-Cyclohexanedicarboxylic acid Spectrum


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