ChemicalBook >> CAS DataBase List >>DL-Mevalonolactone
DL-Mevalonolactone
- CAS No.
- 674-26-0
- Chemical Name:
- DL-Mevalonolactone
- Synonyms
- NSC 90804;Beta-Hydro;Hyperpure-MVA;MEVALONOLACTONE;DL-MEVALOLACTONE;MEVALONIC LACTONE;DL-MEVALONOLACTONE;(+/-)-MEVALONOLACTONE;DL-Mevalonolactone >DL-MEVALONIC ACID LACTONE
- CBNumber:
- CB0377087
- Molecular Formula:
- C6H10O3
- Molecular Weight:
- 130.14
- MDL Number:
- MFCD00006648
- MOL File:
- 674-26-0.mol
Last updated:2024-04-12 23:00:59
| Melting point | 28 °C(lit.) |
|---|---|
| Boiling point | 145-150 °C5 mm Hg(lit.) |
| alpha | -1.0～+1.0°(20℃/D)(c=5, C2H5OH) |
| Density | 1.1066 (rough estimate) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | -20°C |
| solubility | Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate, Methanol (Slightly) |
| form | Oil |
| pka | 13.57±0.20(Predicted) |
| color | Pale Yellow to Dark Brown |
| Merck | 14,6163 |
| BRN | 80960 |
| Stability | Hygroscopic |
| InChIKey | JYVXNLLUYHCIIH-UHFFFAOYSA-N |
| CAS DataBase Reference | 674-26-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 1RJ06DC41B |
| NIST Chemistry Reference | Dl-mevalonic acid lactone(674-26-0) |
SAFETY
Risk and Safety Statements
| WGK Germany | 3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| F | 3-10 | |||||||||
| HS Code | 29322090 | |||||||||
| NFPA 704 |
|
DL-Mevalonolactone price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M4667 | (±)-Mevalonolactone ~97% (titration) | 674-26-0 | 1g | $221 | 2024-03-01 | Buy |
| Sigma-Aldrich | M4667 | (±)-Mevalonolactone ~97% (titration) | 674-26-0 | 5g | $687 | 2024-03-01 | Buy |
| TCI Chemical | D0587 | DL-Mevalonolactone >98.0%(GC) | 674-26-0 | 100mg | $67 | 2024-03-01 | Buy |
| Cayman Chemical | 20348 | DL-Mevalonolactone ≥95% | 674-26-0 | 250mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 20348 | DL-Mevalonolactone ≥95% | 674-26-0 | 500mg | $92 | 2024-03-01 | Buy |
DL-Mevalonolactone Chemical Properties,Uses,Production
Description
DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.
Chemical Properties
Pale Yellow Oil
Uses
(±)-Mevalonolactone is used to:
- study the effect of statin on the prenylation of Ras and Rho GTPases
- analyse the isoprenoid biosynthesis pathways in Listeria monocytogenes
- study the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells)
Uses
HMG CoA substrate
Uses
A metabolite from endophytes of the medicinal plant Erythrina crista-galli.
Definition
ChEBI: 4-hydroxy-4-methyl-2-oxanone is a delta-lactone.
Synthesis Reference(s)
Journal of the American Chemical Society, 104, p. 5486, 1982 DOI: 10.1021/ja00384a040
Synthesis, p. 719, 1974 DOI: 10.1055/s-1974-23416
General Description
Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation.
Purification Methods
Purify the lactone via the dibenzyl-ethylenediammonium salt (m 124-125o) [Hofmann et al. J Am Chem Soc 79 2316 1957], or by chromatography on paper or on a Dowex-1 (formate) column. [Bloch et al. J Biol Chem 234 2595 1959.] Store it as the N,N'-dibenzylethylenediamine (DBED) salt, or as the lactone in a sealed container at 0o. [Beilstein 18/1 V 19.]
DL-Mevalonolactone Preparation Products And Raw materials
Global( 196)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 290 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1268 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
View Lastest Price from DL-Mevalonolactone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Mevalonolactone
674-26-0
|
US $0.00 / kg | 1kg | 99.8% | 1000 kg | BINBO BIOLOGICAL CO.,LTD | |
 |
2024-04-12 | DL-Mevalonolactone
674-26-0
|
US $0.00-0.00 / g | 1g | 99.99% | 20 tons | airuikechemical co., ltd. | |
 |
2023-11-27 | DL-Mevalonolactone
674-26-0
|
US $0.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Mevalonolactone
674-26-0
- US $0.00 / kg
- 99.8%
- BINBO BIOLOGICAL CO.,LTD
-
- DL-Mevalonolactone
674-26-0
- US $0.00-0.00 / g
- 99.99%
- airuikechemical co., ltd.
-
- DL-Mevalonolactone
674-26-0
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
674-26-0(DL-Mevalonolactone)Related Search:
DL-MEVALONOLACTONE
β-Hydroxy-β-methyl-δ-valerolactone, (±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, (±)-Mevalolactone, (±)-Mevalonic acid lactone, (±)-Mevalonolactone
(4S)-4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one
(S)-3,5-Dihydroxy-3-methylpentanoic acid δ-lactone
(S)-4β-Hydroxy-4-methyltetrahydro-2H-pyran-2-one
(S)-Tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one
Beta-Hydro
(±)-Mevalonolactone,(±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone
Tetrahydro-4-hydroxy-4-Methyl-
beta-Hydroxy-beta-methyl-delta-valerolactone
DL-Mevalonic Acid Lactone
Tetrahydro-4-hydroxy-4-methyl-2-pyrone
tetrahydro-4-hydroxy-4-Methylpyran-2-one
DL-MEVALOLACTONE
DL-MEVALONIC ACID LACTONE
DL-BETA-HYDROXY-BETA-METHYL-DELTA-VALERO-LACTONE
DL-BETA-HYDROXY-BETA-METHYL-GAMMA-VALEROLACTONE
DL-BETA-HYDROXY-BETA-METHYL-G-VALEROLACTONE
DL-3-HYDROXY-3-METHYL DELTA-VALEROLACTONE
BETA-HYDROXY-BETA-METHYL-DELTA-VALEROLACTONE
MEVALONIC ACID LACTONE, DL-
MEVALONIC LACTONE
(+/-)-MEVALONOLACTONE
MEVALONOLACTONE
(+/-)-3-HYDROXY-3-METHYL-5-PENTANOLIDE
(4R)-4-Hydroxy-4-methyl-oxan-2-one
(+/-)-tetrahydro-4-hydroxy-4-methyl-2h-pyran-2-one
TETRAHYDRO-4-HYDROXY-4-METHYL-2-PYRONE
2H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-, (.+/-.)-
4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one
D,L-b-Hydroxy-b-methyl-valerolactone
(±)-β-hydroxy-β-methyl-δ-valerolactone
MEVALONIC ACID LACTONE, DL-(RG)
D,L-MEVELONIC ACID LACTONE
DL-B-HYDROXY-B-METHYL-Y-VALEROLACTONE
D,L--Hydroxy--methyl--valerolactone
NSC 90804
(±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone
dl-mevalonic acid lactone, salt-free
DL-Mevalonolactone >
Mevalonolactone, racemic mixture
4-hydroxy-4-methyloxan-2-one
4-Hydroxy-4-methyltetrahydropyran-2-one
Hyperpure-MVA
674-26-0
Organic Building Blocks
Lactones
Metabolomics
Metabolic Libraries
Lipid Library
Building Blocks
BioChemical
Carbonyl Compounds
Heterocycles, Metabolites & Impurities
Heterocycles
Metabolites & Impurities