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Valganciclovir hydrochloride

CAS No.
175865-59-5
Chemical Name:
Valganciclovir hydrochloride
Synonyms
VALGANCICLOVIR HCL;Valcyte;Valcyt;Rs 079070-194;25MG/100MG/1KG;Unii-4p3T9qf9nz;Ro 107-9070/194;Valganciclovir hydrochlorid;VALGANCICLOVIR HYDROCHLORIDE;Valgancyclovir hydrochloride
CBNumber:
CB0380410
Molecular Formula:
C14H23ClN6O5
Molecular Weight:
390.82
MDL Number:
MFCD08460118
MOL File:
175865-59-5.mol
MSDS File:
SDS
Last updated:2023-11-15 15:06:39

Valganciclovir hydrochloride Properties

Melting point 162-164°C
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: ≥8mg/mL
form powder
color white to tan
Stability Hygroscopic
InChIKey ZORWARFPXPVJLW-MTFPJWTKSA-N
CAS DataBase Reference 175865-59-5
FDA UNII 4P3T9QF9NZ
NCI Drug Dictionary Valcyte

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501
WGK Germany  3
HS Code  2933595960
NFPA 704
0
1 0

Valganciclovir hydrochloride price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1626 Valganciclovir Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 175865-59-5 1g $173 2024-03-01 Buy
Sigma-Aldrich 1708004 Valganciclovir hydrochloride hydrate 175865-59-5 500mg $678 2024-03-01 Buy
TCI Chemical V0158 Valganciclovir Hydrochloride 175865-59-5 250MG $48 2024-03-01 Buy
TCI Chemical V0158 Valganciclovir Hydrochloride 175865-59-5 1G $118 2024-03-01 Buy
Cayman Chemical 13875 Valganciclovir (hydrochloride) ≥95% 175865-59-5 10mg $62 2024-03-01 Buy
Product number Packaging Price Buy
PHR1626 1g $173 Buy
1708004 500mg $678 Buy
V0158 250MG $48 Buy
V0158 1G $118 Buy
13875 10mg $62 Buy

Valganciclovir hydrochloride Chemical Properties,Uses,Production

Description

Valganciclovir hydrochloride, a prodrug of the antiviral ganciclovir, was launched in the US for the oral treatment of cytemegalovirus (CMV) retinitis, a sight-threatening complication in patients with AIDS. This L-Valyl ester prodrug can be prepared in three steps from the nucleoside analog ganciclovir by trimethylsilyl-protection of the amino group, coupling with N-benzyloxycarbonyl-L-valine-N-carboxyanhydride, hydrolysis with hydrochloric acid and hydrogenolysis of the Cbz-protecting group. Valganciclovir is well absorbed and rapidly hydrolyzed to ganciclovir by intracellular esterases in the intestinal mucosal cells and by hepatic esterases. Unlike ganciclovir, valganciclovir was demonstrated to be actively transported by the intestinal peptide transporter PEPT1 in Caco-2 cells. As a consequence, its absolute bioavailability in human was 10-fold higher compared to ganciclovir (6%). In clinical trials, it was shown that a twice-daily 900 mg dose of valganciclovir resulted in similar systemic ganciclovir exposure to 5 mg/kg twice-daily intravenous injection of ganciclovir. Valganciclovir concentrations could not be quantified in most patients within three to four hours. In a randomized non-blind phase III clinical trial, oral valganciclovir (900 mg twice daily for three weeks then 900 mg once daily for one week) was as effective as intravenous ganciclovir (5 mg/kg twice daily for three weeks then 5 mg/kg once daily). Oral treatment with valganciclovir avoided catheter-related infection that sometimes occurred with intravenous ganciclovir.

Chemical Properties

White Crystalline Solid

Originator

Roche (Switzerland)

Uses

A pro-drug of ganciclovir. Used in treatment of retro-virus

Uses

Valganciclovir hydrochloride hydrate may be used in HIV-related cell signaling studies.

Uses

Valganciclovir is the valyl ester prodrug of ganciclovir , an antiviral agent used for the treatment of HIV associated retinitis and for the prevention of post transplant cytomegalovirus (CMV) infections. Upon oral administration, intestinal and hepatic esterases rapidly convert valganciclovir to ganciclovir, which can inhibit viral DNA synthesis (IC50 = 0.95 μM) by targeting the CMV polymerase.

Uses

antibacterial, inhibits protein synthesis

brand name

Valcyte (Roche).

General Description

Valganciclovir Hydrochloride is the L-valyl ester of ganciclovir and an antiviral drug, widely used to treat cytomegalovirus infections.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.

Biochem/physiol Actions

Valganciclovir hydrochloride hydrate is an antiviral used to treat cytomegalovirus infection. It is the prodrug of ganciclovir, a synthetic analog of 2′-deoxy-guanosine which is phosphorylated to a dGTP analog that competitively inhibits the incorporation of dGTP by viral DNA polymerase.

Valganciclovir hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 371)Suppliers
Supplier Tel Email Country ProdList Advantage
shandong perfect biotechnology co.ltd
+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2931 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14336 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58

View Lastest Price from Valganciclovir hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Valganciclovir Hydrochloride pictures 2024-03-12 Valganciclovir Hydrochloride
175865-59-5
US $0.00 / KG 1KG 98% HPLC 500kgs shandong perfect biotechnology co.ltd
Valganciclovir Hydrochloride pictures 2023-06-26 Valganciclovir Hydrochloride
175865-59-5
US $2550.00 / kg 1kg 99% 500kg/month Hebei Mingeng Biotechnology Co., Ltd
Valganciclovir hydrochloride pictures 2023-06-15 Valganciclovir hydrochloride
175865-59-5
US $0.00 / KG 1KG 98% 1-1000kg Baoji Guokang Bio-Technology Co., Ltd.

Valganciclovir hydrochloride Spectrum

L-Valine,2-[(2-aMino-1,6-dihydro-6-oxo-9H-purin-9-yl)Methoxy]-3-hydroxypropyl ester,hydrochloride (1:1) 2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-amino-3-methylbutanoate hydrochloride hydrate L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride hydrate Valganciclovir hydrochloride hydrate Rs 079070-194 Unii-4p3T9qf9nz Valcyt Valganciclovir hydrochlorid Valganciclovir Hydrochloride (500 mg) 2-[(2-AMino-1,6-dihydro-6-oxo-9H-purin-9-yl)Methoxy]-3-hydroxypropyl Ester 25MG/100MG/1KG 5-Amino-3-[1-(hydroxymethyl)-2-(L-valyloxy)ethoxymethyl]-6,7- dihydro-3H-imidazo[4,5-d]pyrimidin-7-one hydrochloride L-Valine,2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride VALGANCICLOVIR HYDROCHLORIDE L-VALINE, 2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY]-3-HYDROXYPROPYL ESTER, MONOHYDROCHLORIDE L-VALINE,2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY]-3-HYDROXYPROPYLESTER,MONOHYDROCHLORIDE Ro 107-9070/194 2-((2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-hydroxypropyl L-valinate hydrochloride Valgancyclovir hydrochloride Valganciclovir-d5 HCl (Mixture of Diastereomers) Valganciclovir hydrochloric acid Valganciclovir HCl (Mixture of Diastereomers) Valganciclovir hydrochloride USP/EP/BP Valganciclovir hydrochloride (API) Valganciclovir D5 hydrochlorideQ: What is Valganciclovir D5 hydrochloride Q: What is the CAS Number of Valganciclovir D5 hydrochloride Q: What is the storage condition of Valganciclovir D5 hydrochloride Q: What are the applications of Valganciclovir D5 hydrochloride ValganciclovirHydrochlorideQ: What is ValganciclovirHydrochloride Q: What is the CAS Number of ValganciclovirHydrochloride Q: What is the storage condition of ValganciclovirHydrochloride Q: What are the applications of ValganciclovirHydrochloride Valganciclovir Hydrochloride (1708004) (2S)-2-((2-Amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl 2-amino-3-methylbutanoate hydrochloride Valcyte VALGANCICLOVIR HCL Valganciclovir hydrochloride salt hydrate Valganciclovir Hydrochloride L-Valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]- 3-hydroxy propyl ester hydrochloride 175865-59-5 C14H22N6O5HCl C14H22N6O5ClH Pharmaceuticals Bases & Related Reagents Intermediates & Fine Chemicals Nucleotides CLEOCIN API 175865-59-5