BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE
- CAS No.
- 125-51-9
- Chemical Name:
- BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE
- Synonyms
- qpb;piptal;jb-323;Piptalake;Pipenzolate;PIPENZOLATE BROMIDE;pipenzolatemethobromide;PIPENZOLATE BROMIDE(SH);pipenzolatemethylbromide;XEDCWWFPZMHXCM-UHFFFAOYSA-M
- CBNumber:
- CB0381093
- Molecular Formula:
- C22H28BrNO3
- Molecular Weight:
- 434.37
- MDL Number:
- MFCD00079275
- MOL File:
- 125-51-9.mol
- MSDS File:
- SDS
| Melting point | 179-180° |
|---|---|
| form | powder |
| color | white |
| FDA UNII | JPX41DUS2B |
| ATC code | A03AB14 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| RTECS | TN5425000 |
| Toxicity | LD50 oral in rat: 916mg/kg |
BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P479853 | Piptalake | 125-51-9 | 100mg | $450 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003871 | PIPENZOLATE BROMIDE 95.00% | 125-51-9 | 10G | $1275.81 | 2021-12-16 | Buy |
| AK Scientific | 2658AH | Pipenzolatebromide | 125-51-9 | 1g | $2625 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003871 | PIPENZOLATE BROMIDE 95.00% | 125-51-9 | 50G | $2677.14 | 2021-12-16 | Buy |
| Crysdot | CD31004085 | Pipenzolatebromide 98+% | 125-51-9 | 100mg | $49 | 2021-12-16 | Buy |
BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE Chemical Properties,Uses,Production
Originator
Piptal ,Merrell National ,US ,1955
Uses
antispasmodic
Uses
Piptalake is used in the treatment with copper-tolylterpyridine and platinum-tolylterpyridine that targets telomeres and telomerase for regulation of chromosome mis-segregation rates for cancer therapy.
Manufacturing Process
N-ethyl-3-chloropiperidine was prepared according to the method of Fuson and Zirkle described in Volume 70, J. Am. Chem. Soc., p 2760. 12.0 g (0.081 mol) of N-ethyl-3-chloropiperidine was mixed with 18.6 g (0.081 mol) of benzilic acid and 80 cc of anhydrous isopropyl alcohol as a solvent. The mixture was refluxed for 72 hours. The solution was then filtered and concentrated at 30 mm of mercury. The concentrate was dissolved in water, acidified with hydrochloric acid and extracted with ether to remove theThe aqueous layer was neutralized with sodium bicarbonate and the product was extracted with ether. The ethereal solution of the product was dried with potassium carbonate, the ether was removed by distillation and the residue was distilled at 0.12 to 0.18 mm of mercury, the BP being 194° to 198°C. A yield of 16.5 g (60% of theoretical) of N-ethyl-3-piperidyl-benzilate was obtained.
34 g (0.1 mol) of the basic ester is dissolved in 75 cc of isopropyl alcohol and treated with 9.5 g (0.1 mol) of methyl bromide. The mixture is allowed to stand at room temperature until precipitation is complete. The product is removed by filtration and washed with isopropyl alcohol, yield 33 g, MP 175° to 177°C. On recrystallization from isopropyl alcohol, the MP was raised to 179° to 180°C dec.
brand name
Piptal (Marion Merrell Dow).
Therapeutic Function
Spasmolytic
BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE Preparation Products And Raw materials
BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 7838 | 58 |
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| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Shanghai Jiegu Biotechnology Co., Ltd. | 021-51698675 | jiejiegroup@126.com | China | 4097 | 58 |
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