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ISOXAFLUTOLE

CAS No.
141112-29-0
Chemical Name:
ISOXAFLUTOLE
Synonyms
MERLIN;BALANCE;Ift cpd;Hsdb 7275;Isoxautole;Exp 31130a;SOXAFLUTOLE;ISOXAFLUTOLE;Isoxaflutole 0;Isoxaflutole [iso]
CBNumber:
CB0382227
Molecular Formula:
C15H12F3NO4S
Molecular Weight:
359.32
MDL Number:
MFCD03095707
MOL File:
141112-29-0.mol
MSDS File:
SDS
Last updated:2023-05-25 18:00:56

ISOXAFLUTOLE Properties

Melting point 138-138.5° (Cain); mp 140°
Boiling point 575.1±50.0 °C(Predicted)
Density 1.59
Flash point >130 °C
storage temp. Sealed in dry,2-8°C
solubility Chloroform, DCM, Ethyl Acetate, Methanol
pka -4.29±0.50(Predicted)
color White
BRN 8344543
LogP 2.320
CAS DataBase Reference 141112-29-0
EWG's Food Scores 3
FDA UNII 0T9R0O0EYT
Proposition 65 List Isoxaflutole
Pesticides Freedom of Information Act (FOIA) Isoxaflutole
EPA Substance Registry System Isoxaflutole (141112-29-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS08,GHS09
Signal word  Warning
Hazard statements  H361d-H410
Precautionary statements  P202-P273-P280-P308+P313-P391-P405
Hazard Codes  Xn,N
Risk Statements  50/53-63
Safety Statements  36/37-60-61
RIDADR  UN3077 9/PG 3
WGK Germany  3
Toxicity LD50 in rats, quails, mallard ducks (mg/kg): >5000, >2150, >2150 orally; in rabbits (mg/kg): >2000 dermally (Luscombe)

ISOXAFLUTOLE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46437 Isoxaflutole PESTANAL?, analytical standard 141112-29-0 100mg $147 2024-03-01 Buy
TRC I918140 Isoxaflutole 141112-29-0 10mg $580 2021-12-16 Buy
Medical Isotopes, Inc. 71008 Isoxaflutole 141112-29-0 2.5mg $675 2021-12-16 Buy
American Custom Chemicals Corporation AGR0000257 ISOXAFLUTOLE 95.00% 141112-29-0 5MG $496 2021-12-16 Buy
Crysdot CD11263309 (5-Cyclopropylisoxazol-4-yl)(2-(methylsulfonyl)-4-(trifluoromethyl)phenyl)methanone 95+% 141112-29-0 1g $89 2021-12-16 Buy
Product number Packaging Price Buy
46437 100mg $147 Buy
I918140 10mg $580 Buy
71008 2.5mg $675 Buy
AGR0000257 5MG $496 Buy
CD11263309 1g $89 Buy

ISOXAFLUTOLE Chemical Properties,Uses,Production

Description

Isoxaflutole is a 4-benzoyl isoxazole molecule and is used as a pre- and early post-emergence herbicide for the control of a wide range of important broadleaf and grass weeds in maize (Zea mays), both in Europe and in North America. It is also registered for use in sugarcane in Central and South America (2–4). It causes characteristic bleaching of newly developed tissues of susceptible species followed by growth cessation and necrosis. Marketed as Balance for corn (maize) in the United States, and Merlin for corn in Europe; and in sugarcane, it mixes well with metolachlor, acetochlor, dimethenamid, and atrazine to complete the weed spectrum and to reduce the application rates of the latter compounds (2). Isoxaflutole also controls triazineresistant weeds in the field (4).

Uses

Isoxaflutole is an pesticide used to selectively control both grass and broad-leaved weeds in maize and sugar cane. Isoxaflutole is known to work by inhibiting the enzyme 4-Hydroxyphenylpyruvate dioxygenase (HPPD) which results in the disruption of pigment biosynthesis.

Uses

Herbicide.

Definition

ChEBI: Isoxaflutole is a member of the class of isoxazoles that is 1,2-oxazole substituted by a 2-(methanesulfonyl)-4-(trifluoromethyl)benzoyl group and a cyclopropyl group at positions 4 and 5, respectively. It is a 4-hydroxyphenylpyruvate dioxygenase inhibitor which is used as a herbicide for weed control in maize and sugarcane. It has a role as an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor, a proherbicide and an agrochemical. It is a member of cyclopropanes, a member of isoxazoles, an aromatic ketone, a member of (trifluoromethyl)benzenes and a sulfone.

Pharmacology

Isoxaflutole is readily taken up by roots and foliar tissues and then rapidly degraded to a diketonitrile derivative (2-cyclopropyl-3-(2-mesyl-4-trifluoromethylphenyl)- 3-oxo propanenitrile) , which is translocated throughout the plant via xylem and phloem (2,3,6,8). It is this metabolite that inhibits HPPD (7), thereby depleting the plastoquinone pools in developing leaves. Plastoquinone is a cofactor in the desaturation of phytoene, levels of which increase in bleached leaves, concomitant with decreases in colored carotenoids (6). Although bleaching is the primary symptom associated with HPPD inhibition, subsequent growth suppression and necrosis are also believed to be a consequence (8).
Isoxaflutole also degrades to the diketonitrile derivative in the soil (3,8). The half-life of isoxaflutole in soil is dependent on soil type, pH, and moisture, ranging from 12 hours to 3 days under laboratory conditions (8). The physicochemical properties of isoxaflutole and of diketonitrile play an important role in both soil and herbicidal activity and selectivity (8).

765-43-5
141112-29-0
Synthesis of ISOXAFLUTOLE from Cyclopropyl methyl ketone
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View Lastest Price from ISOXAFLUTOLE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ISOXAFLUTOLE pictures 2019-12-24 ISOXAFLUTOLE
141112-29-0
US $1.00 / g 1g 99.99% 200kg Career Henan Chemical Co
  • ISOXAFLUTOLE pictures
  • ISOXAFLUTOLE
    141112-29-0
  • US $1.00 / g
  • 99.99%
  • Career Henan Chemical Co
MERLIN BALANCE ISOXAFLUTOLE ISOXAFLUTOLE 45% SOLUTION 5-cyclopropyl-4-[2-(methylsulfonyl)-4-(trifluoromethyl)benzoyl]isoxazole isoxaflutole (bsi, pa iso) isoxaflutole (ISO) 5-cyclopropyl-1,2-oxazol-4-yl α,α,α-trifluoro-2-mesyl-p-tolyl ketone Isoxaflutole 0 Isoxautole (5-Cyclopropyl-4-isoxazolyl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]methanone Einecs annex I index 606-054-00-7 Exp 31130a Hsdb 7275 Ift cpd Isoxaflutole [iso] Isoxaflutole 100mg [141112-29-0] (5-Cyclopropylisoxazol-4-yl)(2-(methylsulfonyl)-4-(trifluoromethyl)phenyl)methanone Isoxaflutole 97% TC Isoxaflutole pesticide Isoxautole Solution,100ppm SOXAFLUTOLE Isoxaflutole@100 μg/mL in AcCN Methanone, (5-cyclopropyl-4-isoxazolyl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]- 5-cyclopropyl-4-[2-methanesulfonyl-4-(trifluorome thyl)benzoyl]-1,2-oxazole Isoxaflutole Solution in Acetonitrile, 1000μg/mL 141112-29-0