ChemicalBook >> CAS DataBase List >>BETA-AMANITIN
BETA-AMANITIN
- CAS No.
- 21150-22-1
- Chemical Name:
- BETA-AMANITIN
- Synonyms
- b-Amanitin;β-Amanitin;B-Amanitine;β-Amanitine;BETA-AMANITIN;beta-amatoxin;beta-Amanitine;β-Amanitin DISCONTINUED;1-l-asparticacid-alpha-amaniti;α-Amanitin, 1-L-aspartic acid-
- CBNumber:
- CB0383204
- Molecular Formula:
- C39H53N9O15S
- Molecular Weight:
- 919.95
- MDL Number:
- MFCD00151212
- MOL File:
- 21150-22-1.mol
Last updated:2023-06-08 09:02:24
| Melting point | 300° |
|---|---|
| Boiling point | 1599.6±65.0 °C(Predicted) |
| Density | 1.1725 (rough estimate) |
| refractive index | 1.7400 (estimate) |
| storage temp. | −20°C |
| solubility | Water: 1 mg/ml |
| pka | 4.02±0.10(Predicted) |
| form | White to off-white powder. |
| FDA UNII | G729YPP47L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330 | |||||||||
| Precautionary statements | P260-P262-P264-P280-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28 | |||||||||
| Safety Statements | 7-28-36/37/39-45 | |||||||||
| RIDADR | UN 3462 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NJ8324000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 2934999090 | |||||||||
| Toxicity | LD50 i.p. in albino mice: 0.4 mg/kg (Wieland, Wieland) | |||||||||
| NFPA 704 |
|
BETA-AMANITIN price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A1304 | β-Amanitin from Amanita phalloides ~90% (HPLC) | 21150-22-1 | 1mg | $865 | 2024-03-01 | Buy |
| Cayman Chemical | 18142 | β-Amanitin ≥95% | 21150-22-1 | 1mg | $241 | 2024-03-01 | Buy |
| Biosynth Carbosynth | FA57612 | b-Amanitin | 21150-22-1 | 1mg | $300 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA57612 | b-Amanitin | 21150-22-1 | 2mg | $400 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA57612 | b-Amanitin | 21150-22-1 | 5mg | $600 | 2021-12-16 | Buy |
BETA-AMANITIN Chemical Properties,Uses,Production
Acute toxicity
peritoneal-mouse LD50: 0.4 mg/kg; unnamed-mouse LD50: 0.4 mg/kg
Uses
β-Amanitin from Amanita phalloides has been used:
- as a calibration standard for the quantification of β-Amanitin using liquid chromatography-high resolution-mass spectrometry/mass spectrometry (LC-HR-MS/MS) method.
- to determine its concentration in urine samples by capillary zone electrophoresis (CZE).
- in the analysis of β-amanitin in toxic mushrooms by liquid chromatography coupled to time-of-flight mass spectrometry.
Mechanism of action
β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi. It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis. The biological activity of this toxin is similar to that of α-amanitin but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions.
Uses
As a tool in molecular biology.
General Description
β-Amanitin belongs to the family of amatoxins. Amanitins are made of bicyclic octapeptides. β-Amanitin is composed of a carboxyl group and is acidic in nature.
Biochem/physiol Actions
Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.
BETA-AMANITIN Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 48)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18457 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
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21150-22-1
C39H53N9O15S
DNA-RNA Transcription Regulators
Gene Regulation and Expression
BioChemical
Cell Signaling and Neuroscience
Cell Biology
Cell Signaling and Neuroscience
DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience
Gene Regulation and Expression
Mushroom
Toxins and Venoms