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N-Hydroxysuccinimide

N-Hydroxysuccinimide
N-Hydroxysuccinimide structure
CAS No.
6066-82-6
Chemical Name:
N-Hydroxysuccinimide
Synonyms
NHS;HOSU;HONSU;HOSU/NHS;HOSU 25 G;AKOS 91864;NHS OR HONSU;HOSu Novabiochem;Hydroxysuccinimide;N-HYDROXYSUCCINIMDE
CBNumber:
CB0391283
Molecular Formula:
C4H5NO3
Formula Weight:
115.09
MOL File:
6066-82-6.mol

N-Hydroxysuccinimide Properties

Melting point:
95-98 °C(lit.)
Boiling point:
215.33°C (rough estimate)
Density 
1.4769 (rough estimate)
refractive index 
1.4080 (estimate)
storage temp. 
Store at +2°C to +8°C.
form 
Liquid or Solid
pka
7.81±0.20(Predicted)
color 
Clear yellow-brown to brown
PH
5-7 (50g/l, H2O, 20℃)
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
BRN 
113913
Stability:
Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture.
InChIKey
NQTADLQHYWFPDB-UHFFFAOYSA-N
CAS DataBase Reference
6066-82-6(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
MJE3791M4T
NIST Chemistry Reference
N-hydroxylsuccinimide(6066-82-6)
EPA Substance Registry System
2,5-Pyrrolidinedione, 1-hydroxy- (6066-82-6)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-26-36
WGK Germany  3
Hazard Note  Irritant
TSCA  Yes
HS Code  29251995
NFPA 704
1
2 1

N-Hydroxysuccinimide price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.51056 HOSu Novabiochem? 6066-82-6 25 g $18.8 2021-12-16 Buy
Sigma-Aldrich 8.04518 N-Hydroxysuccinimide for synthesis 6066-82-6 25 g $33.76 2021-12-16 Buy
Sigma-Aldrich 8.51056 HOSu Novabiochem? 6066-82-6 100 g $64.1 2021-12-16 Buy
Sigma-Aldrich 8.04518 N-Hydroxysuccinimide for synthesis 6066-82-6 100 g $104.52 2021-12-16 Buy
Sigma-Aldrich 8.04518 N-Hydroxysuccinimide for synthesis 6066-82-6 500 g $343.17 2021-12-16 Buy

N-Hydroxysuccinimide Chemical Properties,Uses,Production

Description

N-hydroxysuccinimide is a synthetic ingredient used in cosmetics as an ester to soften and condition skin. It's also a reagent, a substance used to trigger a reaction that leads to a new substance, such as peptides and polymers.
N-Hydroxysuccinimide is used in cosmetics and beauty products as an ester often seen in eye creams. N-hydroxysuccinimide activates the elimination of blood originated pigments responsible for dark color and inflammation that causes under eye circles. "Infra-orbital shadows are due to the accumulation of hemoglobin and its coloured degradation products - biliverdin, bilirubin and iron - in the dermis and epidermis ... N-hydroxysuccinimide renders the iron soluble for natural elimination" (source).

Chemical Properties

White to pale yellow

Uses

Reagent for preparation of active esters of amino acids.

Uses

N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide.

Uses

N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

Application

N-Hydroxysuccinimide has been used in the synthesis of intermediates such as:
N-succinimidyl 3-(di-tert-butylfluorosilyl)benzoate
4-[2,2-bis[(p-tolylsulfonyl)-methyl] acetyl]benzoic acid-NHS ester
N-succinimidyl 3-iodobenzoate
It has also been used in a protocol for the surface modification of microchannels of a microfluidic-integrated surface plasmon resonance (SPR) platform for the detection and quantification of bacterial pathogens.
Additive used in the carbodiimide method for improved amidations and peptide couplings.
N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid.

Purification Methods

Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.]

N-Hydroxysuccinimide Preparation Products And Raw materials

Raw materials

Preparation Products


N-Hydroxysuccinimide Suppliers

Global( 628)Suppliers
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Capot Chemical Co.,Ltd.
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+86-371-66670886
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Henan Tianfu Chemical Co.,Ltd.
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Fluoropharm Co., Ltd.
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ATK CHEMICAL COMPANY LIMITED
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AB PharmaTech,LLC
323-480-4688
323-480-4688 sales01@abpharmatechusa.com United States 989 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Zjartschem
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Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58

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View Lastest Price from N-Hydroxysuccinimide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 N-Hydroxysuccinimide
6066-82-6
US $9.00 / ASSAYS 1ASSAYS 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-11-30 N-Hydroxysuccinimide
6066-82-6
US $48.00 / KG 25Kg/Drum 99% 100T Baoji Guokang Bio-Technology Co., Ltd.
2021-09-04 N-Hydroxysuccinimide
6066-82-6
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

N-Hydroxysuccinimide Spectrum


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