BuforMin Hydrochloride
- CAS No.
- 1190-53-0
- Chemical Name:
- BuforMin Hydrochloride
- Synonyms
- BUTYL-BIGUANIDE HYDROCHLORIDE;Andere;Adebit;TideMol;Biforon;Sindiatil;PanforMin;Ziavetine;NSC528218;Aids126511
- CBNumber:
- CB0407151
- Molecular Formula:
- C6H16ClN5
- Molecular Weight:
- 193.68
- MDL Number:
- MFCD00045591
- MOL File:
- 1190-53-0.mol
- MSDS File:
- SDS
| Melting point | 177-179?C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| CAS DataBase Reference | 1190-53-0 |
| FDA UNII | D947SXO87P |
| NCI Drug Dictionary | buformin hydrochloride |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338+P310-P332+P313-P403+P233-P405-P501 | |||||||||
| Risk Statements | 22-43-36 | |||||||||
| Safety Statements | 36/39-46 | |||||||||
| HS Code | 29212900 | |||||||||
| Toxicity | LD50 i.p. in mice: 380 mg/kg (Rikimaru) | |||||||||
| NFPA 704 |
|
BuforMin Hydrochloride price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B6007 | Buformin Hydrochloride | 1190-53-0 | 50MG | $45 | 2024-03-01 | Buy |
| TCI Chemical | B6007 | Buformin Hydrochloride | 1190-53-0 | 250MG | $154 | 2024-03-01 | Buy |
| Cayman Chemical | 18507 | Buformin (hydrochloride) ≥95% | 1190-53-0 | 100mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 18507 | Buformin (hydrochloride) ≥95% | 1190-53-0 | 250mg | $188 | 2024-03-01 | Buy |
| Cayman Chemical | 18507 | Buformin (hydrochloride) ≥95% | 1190-53-0 | 500mg | $356 | 2024-03-01 | Buy |
BuforMin Hydrochloride Chemical Properties,Uses,Production
Description
Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
Chemical Properties
White Solid
Originator
Silubin,Protochemie,Switz.
Uses
Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.
Uses
BuforMin Hydrochloride is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. BuforMin Hydrochloride has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
Manufacturing Process
105.6 g of n-butylamine hydrochloride and 79.3 g of dicyandiamide were ground intimately and mixed. The mixture was heated by means of an oil bath, gradually with stirring, and after thirty minutes when the internal temperature had reached 150°C, an exothermic reaction ensued with internal pressure rising to 178°C. The reaction mixture was removed from the oil bath until the internal temperature had fallen to 150°C and then heating was resumed at 150°C for one hour. The cooled fusion mixture was dissolved in 3 liters of acetonitrile and on cooling n-butyl-biguanide hydrochloride precipitated.
Therapeutic Function
Antidiabetic
BuforMin Hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| LY Global chemicals co.,ltd . | +8618939937369 | info@lychems.cn | China | 969 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
View Lastest Price from BuforMin Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-16 | BuforMin Hydrochloride
1190-53-0
|
US $0.00-0.00 / g | 10g | 98%Min | 1000kg | LY Global chemicals co.,ltd . | |
 |
2020-02-11 | Buformin Hydrochloride
1190-53-0
|
US $9.80 / KG | 1g | ＞98% | 20 tons | Career Henan Chemical Co |
-
- BuforMin Hydrochloride
1190-53-0
- US $0.00-0.00 / g
- 98%Min
- LY Global chemicals co.,ltd .
-
- Buformin Hydrochloride
1190-53-0
- US $9.80 / KG
- ＞98%
- Career Henan Chemical Co
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