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Acetyl tributyl citrate

Acetyl tributyl citrate
Acetyl tributyl citrate structure
CAS No.
77-90-7
Chemical Name:
Acetyl tributyl citrate
Synonyms
ATBC;Blo-trol;Estaflex;FEMA 3080;citroflexa;Uniplex 84;Citroflex A;citroflexa4;Citroflex A 4;acetylbutylcitrate
CBNumber:
CB0408022
Molecular Formula:
C20H34O8
Formula Weight:
402.48
MOL File:
77-90-7.mol

Acetyl tributyl citrate Properties

Melting point:
-59 °C
Boiling point:
327 °C
Density 
1.05 g/mL at 25 °C(lit.)
vapor pressure 
0.26 psi ( 20 °C)
FEMA 
3080 | TRIBUTYL ACETYLCITRATE
refractive index 
n20/D 1.443(lit.)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride.
form 
neat
Water Solubility 
<0.1 g/100 mL
FreezingPoint 
-80℃
JECFA Number
630
BRN 
2303316
InChIKey
QZCLKYGREBVARF-UHFFFAOYSA-N
CAS DataBase Reference
77-90-7(CAS DataBase Reference)
FDA 21 CFR
172.515; 175.105; 175.300; 175.320; 181.27
Substances Added to Food (formerly EAFUS)
TRIBUTYL ACETYLCITRATE
EWG's Food Scores
1
FDA UNII
0ZBX0N59RZ
NIST Chemistry Reference
1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7)
EPA Substance Registry System
Acetyl tributyl citrate (77-90-7)
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
WGK Germany  3
RTECS  TZ8330000
HS Code  29181500

Acetyl tributyl citrate price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1009901 Acetyltributyl citrate United States Pharmacopeia (USP) Reference Standard 77-90-7 200mg $345 2019-12-02 Buy
Sigma-Aldrich 1009901 Acetyltributyl citrate United States Pharmacopeia (USP) Reference Standard 77-90-7 500mg $410 2019-12-02 Buy
TCI Chemical A0822 Tributyl O-Acetylcitrate >97.0%(GC) 77-90-7 25mL $14 2020-06-24 Buy
TCI Chemical A0822 Tributyl O-Acetylcitrate >97.0%(GC) 77-90-7 500mL $49 2020-06-24 Buy
Sigma-Aldrich 388378 Tributyl O-acetylcitrate 98% 77-90-7 500ml $51.2 2019-12-02 Buy

Acetyl tributyl citrate Chemical Properties,Uses,Production

Chemical Properties

clear colorless liquid

Chemical Properties

Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.

Chemical Properties

Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.

Chemical Properties

Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.

Uses

Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.

Uses

plasticizer flavoring agent

Definition

Aqueous-based pharmaceutical coat- ings.

Preparation

From citric acid via the tributyl ester followed by acetylation.

Production Methods

Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.

Pharmaceutical Applications

Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes. ADD750

Safety

and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): >4 g/kg
LD50 (rat, oral): >31.5 g/kg

Carcinogenicity

The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.

storage

Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.

Incompatibilities

Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

Acetyl tributyl citrate Preparation Products And Raw materials

Raw materials

Preparation Products


Acetyl tributyl citrate Suppliers

Global( 220)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2678 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21838 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10154 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23045 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58

View Lastest Price from Acetyl tributyl citrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-21 acetyl tributyl citrate
77-90-7
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2018-12-18 Acetyl tributyl citrate
77-90-7
US $1.00 / kg 1kg 97%min 1000kg career henan chemical co

Acetyl tributyl citrate Spectrum


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