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Acetyl tributyl citrate

Chemical Name:
Acetyl tributyl citrate
ATBC;TRIBUTYL ACETYLCITRATE;Acetyltributylcitrat;TRIBUTYL O-ACETYLCITRATE;Tributyl citrate acetate;citroflexa4;Acetyl butyl citrate;tributylcitrateacetate;ACETYL TRI-N-BUTYL CITRATE;tributyl 2-acetoxypropane-1,2,3-tricarboxylate
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:

Acetyl tributyl citrate Properties

Melting point -59 °C
Boiling point 327 °C
Density 1.05 g/mL at 25 °C (lit.)
vapor pressure 0.26 psi ( 20 °C)
refractive index n20/D 1.443(lit.)
Flash point >230 °F
storage temp. Store below +30°C.
solubility Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride.
form neat
color Clear Colourless
Water Solubility <0.1 g/100 mL
FreezingPoint -80℃
JECFA Number 630
BRN 2303316
CAS DataBase Reference 77-90-7(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) TRIBUTYL ACETYLCITRATE
FDA 21 CFR 172.515; 175.105; 175.300; 175.320; 181.27
EWG's Food Scores 1
NIST Chemistry Reference 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7)
EPA Substance Registry System Acetyl tributyl citrate (77-90-7)
Cosmetics Info Acetyl Tributyl Citrate


Risk and Safety Statements

Safety Statements  24/25
WGK Germany  3
RTECS  TZ8330000
HS Code  29181500

Acetyl tributyl citrate price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1009901 Acetyltributyl citrate United States Pharmacopeia (USP) Reference Standard 77-90-7 500mg $450 2022-05-15 Buy
TCI Chemical A0822 Tributyl O-Acetylcitrate >97.0%(GC) 77-90-7 25mL $16 2022-04-27 Buy
TCI Chemical A0822 Tributyl O-Acetylcitrate >97.0%(GC) 77-90-7 500mL $50 2022-04-27 Buy
Sigma-Aldrich W308005 Tributyl 2-acetylcitrate ≥98%, FG 77-90-7 sample $53.8 2022-05-15 Buy
Sigma-Aldrich W308005 Tributyl 2-acetylcitrate ≥98%, FG 77-90-7 1kg $73.3 2022-05-15 Buy
Product number Packaging Price Buy
1009901 500mg $450 Buy
A0822 25mL $16 Buy
A0822 500mL $50 Buy
W308005 sample $53.8 Buy
W308005 1kg $73.3 Buy

Acetyl tributyl citrate Chemical Properties,Uses,Production

Chemical Properties

Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.

Chemical Properties

clear colorless liquid

Chemical Properties

Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.

Chemical Properties

Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.


plasticizer flavoring agent


Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.


Aqueous-based pharmaceutical coat- ings.

Production Methods

Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.


From citric acid via the tributyl ester followed by acetylation.

General Description

Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmaceutical Applications

Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes. ADD750


and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): >4 g/kg
LD50 (rat, oral): >31.5 g/kg


The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.


Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.


Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

Acetyl tributyl citrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 325)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418679 China 2995 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 22021 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 China 9383 55
career henan chemical co
+86-0371-86658258 China 29959 58
+86 18953170293 CHINA 2940 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254 CHINA 28229 58
Jinan Finer Chemical Co., Ltd
531-88989536 +8615508631887 China 2995 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 +86-19930503282 China 5953 58
Xiamen AmoyChem Co., Ltd
592-6051114 CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602 CHINA 23035 58

View Lastest Price from Acetyl tributyl citrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-02-19 Tributyl Acetylcitrate
US $0.00 / KG 1KG 99.1% 100 tons Honest Joy Holdings Limited
2021-12-25 Acetyl tributyl citrate
2021-12-01 Acetyl Tributyl Citrate
US $5.70 / Kg/Drum 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
Uniplex 84 butyl acetylcitrate TRIBUTYL ACETYLCITRATE 98+% CITROFLEX A4 FOR GAS CHROMATOGRAPHY & FEMA 3080 Tributyl O-acetylcitrate,Acetyl tributyl citrate, Tributyl 2-acetylcitrate Tributyl 2-acetylcitrate,Acetyl tributyl citrate Acetyltributyl Citrate (500 mg) O-ACETYLTRIBUTYLCITRATE TRI-N-BUTYLACETYLCITRATE Acetyl tributyl citrate, Tributyl 2-acetylcitrate O-ACETYLCITRIC ACID TRIBUTYL ESTER TRIBUTYL 2-ACETOXY-1,2,3-PROPANETRICARBOXYLATE TRIBUTYL 2-ACETYLCITRATE TRIBUTYLACETYL CITRATE FOR SYNTHESIS Tributyl O-acetylcitrate 98% Acetyl tributyl citrate Tributyl O-Acetylcitrate O-Acetylcitric Acid Tributyl Ester ATBC 2-acetyltributylcitrate Acetyl tributyl citrate1,2,3-propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester acetylbutylcitrate Acetylcitric acid, tributyl ester acetylcitricacid,tributylester acetylcitricacidtributylester Blo-trol Citric acid, tributyl ester, acetate citricacid,tributylester,acetate Citroflex A Citroflex A 4 citroflexa Estaflex Pfizer citroflex A-4 Tributyl 2-(acetyloxy)-1,2,3-propanetricarboxylate Tributyl 2-(acetyloxy)-1,2,3-propanetricarboxylic acid Tributyl acetylicitrate tributyl2-(acetyloxy)-1,2,3-propanetricarboxylate ACETYL TRIBUTYL CITRATE Tributyl-Acethylcitrate Acetyl tributyl citrate 10g [77-90-7] 1,2,3-Propanetricarboxylic acid, 2-acetoxy-, tributyl ester 1,2,3-Propanetricarboxylicacid,2-(acetyloxy)-,tributylester 2-(Acetyloxy)-1,2,3-propane tricarboxylic acid, tributyl ester 2,3-propanetricarboxylicacid,2-(acetyloxy)-tributylester 2-Acetoxy-1,2,3-propanetricarboxylic acid tributyl ester 2-acetoxy-1,2,3-propanetricarboxylicacidtributylester 1,2,3-Tributyl 2-acetyloxypropane-1,2,3-tricarboxylate 3-O-Acetylcitric acid tributyl ester Acetyl tributyl citrate,99% tributyl 2-acetyloxypropane-1,2,3-tricarboxylate Tributyl O-acetylcitrate, 98.5% Acetyl Tributyl Citrate(Reach) 2-acetyloxypropane-1,2,3-tricarboxylic acid tributyl ester 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, 1,2,3-tributyl ester Tributyl acetylcitrate for peak identification CRS Tributyl acetylcitrate CRS Tributyl O-Acetylcitrate > Acetyl tributyl citrate fandachem Acetyl tributyl citrate ISO 9001:2015 REACH Acetyl Tributyl Citrate, ATBC Platicizer CAS 77-90-7