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Diethylene glycol

Diethylene glycol
Diethylene glycol structure
Chemical Name:
Diethylene glycol
DEG;Her;TL4N;Dicol;DIGOL;Digenos;DIGLYCOL;NSC 36391;brecolanendg;deactivatore
Molecular Formula:
Formula Weight:
MOL File:

Diethylene glycol Properties

Melting point:
−10 °C(lit.)
Boiling point:
245 °C(lit.)
1.118 g/mL at 25 °C(lit.)
vapor density 
2.14 (vs air)
vapor pressure 
0.01 mm Hg ( 20 °C)
refractive index 
n20/D 1.447(lit.)
Flash point:
143 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
H2O: 50 mg/mL at 20 °C, clear, colorless
Oily Liquid
Practically odorless.
Relative polarity
5.5-7.0 (25℃, 50mg/mL in H2O)
explosive limit
Water Solubility 
λ: 260 nm Amax: ≤0.02
λ: 280 nm Amax: ≤0.01
Indirect Additives used in Food Contact Substances
175.105; 175.300; 175.320; 177.2420; 177.2800
CAS DataBase Reference
111-46-6(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
Ethanol, 2,2'-oxybis-(111-46-6)
EPA Substance Registry System
Diethylene glycol (111-46-6)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H320-H302-H373
Precautionary statements  P264-P270-P305+P351+P338+P337+P313-P501-P301+P312a-P330-P501a-P260-P301+P312+P330
Hazard Codes  Xn,T,Xi
Risk Statements  22
Safety Statements  46
WGK Germany  1
RTECS  ID5950000
Autoignition Temperature 442 °F
Hazard Note  Toxic/Irritant
HS Code  29094100
Toxicity LD50 in rats, guinea pigs (g/kg): 20.76, 13.21 orally (Smyth)
NFPA 704
1 0

Diethylene glycol price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 93171 Diethylene glycol BioUltra, ≥99.0% (GC) 111-46-6 100 mL $52.2 2021-03-22 Buy
Sigma-Aldrich 03128 Diethylene glycol analytical standard 111-46-6 5ml-f $89.3 2020-08-18 Buy
Sigma-Aldrich 03128 Diethylene glycol analytical standard 111-46-6 5 mL $92.1 2021-03-22 Buy
Sigma-Aldrich 32160 Diethylene glycol puriss. p.a., ≥99.0% (GC), colorless 111-46-6 1l $121 2020-08-18 Buy
Sigma-Aldrich 93171 Diethylene glycol BioUltra, ≥99.0% (GC) 111-46-6 500 mL $136 2021-03-22 Buy

Diethylene glycol Chemical Properties,Uses,Production

Chemical Properties

Diethylene glycol is a clear colorless, odorless and stable oily liquid. It is also slightly viscous, noncorrosive and nonvolatile. Because of its ether and alcohol group, diethylene glycol exhibits chemical properties characteristic of both primary alcohols and ethers. Its boiling point is considerably higher than that of ethylene glycol, and its solvent is greater. Diethylene glycol is miscible with water, ethers, lower aliphatic alcohols, aldehydes and ketones and is partially soluble in benzene, carbon tetrachloride, monobenzene, orthodichlorobenzene and toluene. It dissolves many dyes, resins, oils, nitrocellulose and many organic substances. Because of its solvent power, low volatility and hygroscopicity, it is used in textile lubricants, cutting oils, dry cleaning soap, printing inks, steam-set inks, and nongrain wood stains. In the textile industry diethylene glycol is used as a conditioning agent for wool, rayon, and cotton. As a solvent for dyes it makes a valuable assistant in dyeing and printing. The high hygroscopicity of diethylene glycol makes it an efficient softening agent for tobacco, paper, synthetic sponges, glues and casein. Diethylene glycol is especially useful in the dehydration of natural gas. A mixture of diethylene glycol and monoethanolamine will remove moisture, hydrogen sulfide and carbon dioxide from natural gas.
diethylene glycol structure
diethylene glycol structure


In antifreeze solution for sprinkler systems, water seals for gas tanks, etc. (water with 40% diethylene glycol freezes at -18°; with 50% at -28°); as lubricating and finishing agent for wool, worsted, cotton, rayon, and silk; as solvent for vat dyes; in composition corks, glues, gelatin, casein, and pastes to prevent drying out.


Diethylene glycol is a colorless, odorless, clear liquid. It is miscible with water in any ratio. It has many industrial uses. It is a component of antifreeze, brake fluids, cosmetics, inks, and drying agents, and it is used as a plasticizer.


Diethylene glycol (DEG) is a commonly used solvent and ingredient in numerous commercial products. It is used as a dehydrating agent for natural gas processing; as a lubricating and finishing agent for textiles; a constituent in brake fluids, lubricants, antifreeze formulations, wallpaper strippers and in artificial fog solutions; a solvent for printing inks and textile dyes; and is used as an intermediate in the production of some resins, triethylene glycol, surfactants, and diethylene glycol esters and ethers.

Production Methods

Diethylene glycol is produced commercially as a by-product of ethylene glycol production. It can also be produced directly by reaction between ethylene glycol and ethylene oxide .

General Description

A colorless liquid. Denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Diethylene glycol is incompatible with strong oxidizing agents. Diethylene glycol is also incompatible with strong bases. Diethylene glycol can react with sulfuric acid and other dehydrating agents, nitric acid, oxygen, hydrogen peroxide, perchloric acid and strong acids. Mixtures with sodium hydroxide decompose exothermically when heated to 446° F.

Health Hazard

Ingestion of large amounts may cause degeneration of kidney and liver and cause death. Liquid may cause slight skin irritation.

Fire Hazard

Diethylene glycol is combustible.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pert.


The toxicity of diethylene glycol is similar to ethylene glycol and clearly is a CNS depressant. It has a low inhalation hazard because of its low vapor pressure; however, inhalation of the mist or aerosol is to be avoided. Workplace levels for vapors and aerosols cannot exceed 50 ppm. In case of accidental release of diethylene glycol, use of a full-face positive air pressure respirator is recommended. Even though the toxicokinetics in humans is not completely understood, its toxic nature is confirmed by animal studies. Several human cases were reported in the medical literature. Several children in Haiti died in 1995 and 1996 following the consumption of medication containing diethylene glycol. Similar other cases in children were reported in other countries as well. A 24-year-old man developed encephalopathy and rapidly became quadriplegic following ingestion of a solution containing diethylene glycol . Thus, the toxicity of diethylene glycol is well established.

Safety Profile

Moderately toxic to humans by ingestion. Poison experimentally by inhalation. Moderately toxic by ingestion and intravenous routes. Questionable carcinogen with experimental carcinogenic,tumorigenic, and teratogenic data. An eye and human skin irritant. Combustible when exposed to heat or flame; can react with oxidning materials. To fight fire, use alcohol foam, water, Con, dry chemical. Mixtures with sodium hydroxide decompose exothermically when heated to 230℃ and release explosive hydrogen gas. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.


Weil et al. , in their longterm studies on rats of three different age levels, found only one bladder tumor in those fed diets that contained 4% diethylene glycol. This tumor was in a rat that also had bladder stones . To clarify the question of the cause of the tumor, Weil et al. implanted calcium oxalate stones or glass beads into the bladders of rats. They found that bladder tumors never developed without the presence of a foreign body in the bladder. This led to the conclusion that diethylene glycol essentially free of ethylene glycol is not a primary carcinogen.

Environmental Fate

Diethylene glycol is metabolized by alcohol dehydrogenase to toxic metabolites predominantly, HEAA and DGA. DEG can cause an anion gap metabolic acidosis, cortical necrosis resulting in permanent renal failure and neurotoxicity. DGA, not HEAA, was recently identified as being the primary nephrotoxic agent causing proximal tubule cell death. The neurotoxicity seen after DEG poisoning is only recently described. The neurotoxicity is delayed and has cranial and peripheral demyelinating sensorimotor polyneuropathy pattern. The exact mechanism of the neurotoxicity remains unclear and in the cases described in the literature, it appears to be prolonged but does show evidence of reversibility.

Toxicity evaluation

Diethylene glycol is miscible with water, has a low vapor pressure of 0.008 hPa at 25°C, a very low log Kow of 1.98, and also a low Koc. Consequently, water is the most relevant environmental compartment. Calculation according to Mackay, Level I indicates the following distribution among environmental compartments: air 0.75%, water 99.25%, soil 0%, sediment 0%; confirming the relevance of the pelagic systems.
The substance is readily biodegradable and the very low log Kow suggests a low potential for bioaccumulation.

Diethylene glycol Preparation Products And Raw materials

Raw materials

Preparation Products

Diethylene glycol Suppliers

Global( 548)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37127788 CHINA 497 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 8882 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 3001 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 29960 58
Hebei Zhuangkai Biotechnology Co.,Ltd.
0311-89850048 China 299 58
+86 18953170293
+86 0531-67809011 CHINA 2858 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 China 5460 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58

View Lastest Price from Diethylene glycol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Diethylene glycol
US $1.52 / g 1KG 99% 500Tons Wuhan wingroup Pharmaceutical Co., Ltd
2021-10-14 99.9% Diethylene Glycol (DEG)
US $1800.00 / Kg/Drum 25Kg/Drum 99% 20ton Hebei Dongdu Import and Export Co. LTD
2021-10-14 Diethylene Glycol
US $11000.00 / Kg/Drum 1KG 99.9% 20tons Hebei Dongdu Import and Export Co. LTD

Diethylene glycol Spectrum

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