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5-BROMO-2-FLUOROANILINE

CAS No.
2924-09-6
Chemical Name:
5-BROMO-2-FLUOROANILINE
Synonyms
0/6/24;5-Bromo Aniline;5-BROMO-2-FLUOROANIL;5-Bromo-2-fuoroaniline;2-Fluoro-5-Bromoaniline;5-BROMO-2-FLUOROANILINE;2,4-di(propan-2-yl)phenol;5-Bromo-2-fluoroaniline ,98%;Benzenamine, 5-bromo-2-fluoro-;1-Amino-5-bromo-2-fluorobenzene
CBNumber:
CB0417457
Molecular Formula:
C6H5BrFN
Molecular Weight:
190.01
MDL Number:
MFCD03094181
MOL File:
2924-09-6.mol
Last updated:2025-07-24 18:13:53

5-BROMO-2-FLUOROANILINE Properties

Melting point 27℃
Boiling point 105 °C / 12mmHg
Density 1.694±0.06 g/cm3(Predicted)
refractive index 1.59
Flash point 27 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form Solid
pka 2.13±0.10(Predicted)
color White or Colorless to Yellow to Orange
Water Solubility Slightly soluble in water.
InChI InChI=1S/C6H5BrFN/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2
InChIKey ADWKOCXRCRSMLQ-UHFFFAOYSA-N
SMILES C1(N)=CC(Br)=CC=C1F
CAS DataBase Reference 2924-09-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS06
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H302-H312-H331-H335
Precautionary statements  P304+P340-P305+P351+P338-P405-P501a-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501
Hazard Codes  T,Xi,Xn
Risk Statements  22-36-52-36/37/38-20/21/22
Safety Statements  26-60-36/37-9
RIDADR  2811
Hazard Note  Toxic
HazardClass  IRRITANT, TOXIC
HazardClass  6.1
HS Code  29214990
NFPA 704
0
2 0

5-BROMO-2-FLUOROANILINE price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B3043 5-Bromo-2-fluoroaniline >95.0%(GC) 2924-09-6 5g $20 2025-07-31 Buy
TCI Chemical B3043 5-Bromo-2-fluoroaniline >95.0%(GC) 2924-09-6 25g $77 2025-07-31 Buy
Alfa Aesar H61678 5-Bromo-2-fluoroaniline, 98% 2924-09-6 25g $73 2025-07-31 Buy
Alfa Aesar H61678 5-Bromo-2-fluoroaniline, 98% 2924-09-6 100g $187 2025-07-31 Buy
TRC B961493 5-Bromo-2-fluoroaniline 2924-09-6 1g $45 2021-12-16 Buy
Product number Packaging Price Buy
B3043 5g $20 Buy
B3043 25g $77 Buy
H61678 25g $73 Buy
H61678 100g $187 Buy
B961493 1g $45 Buy

5-BROMO-2-FLUOROANILINE Chemical Properties,Uses,Production

Chemical Properties

Light yellow solid

Uses

5-Bromo-2-fluoroaniline is used as pharmaceutical intermediate.

Synthesis

4-Bromo-1-fluoro-2-nitrobenzene

364-73-8

5-BROMO-2-FLUOROANILINE

2924-09-6

General procedure for the synthesis of 5-bromo-2-fluoroaniline from 4-bromo-1-fluoro-2-nitrobenzene: 5-bromo-2-fluoro nitrobenzene (698 g) was dissolved in 95% ethanol (0.90 L), which was subsequently added to a mixed system of powdered iron (711 g) and saturated aqueous ammonium chloride (2.0 L). The reaction mixture was stirred continuously at 70°C for 24 hours (the reaction process was monitored by HPLC until complete). Upon completion of the reaction, the mixture was cooled to room temperature, filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to remove the solvent. The residue was subjected to liquid-liquid extraction with ethyl acetate (2 L) and water (2 L) to separate the organic and aqueous phases. The aqueous phase was further extracted once with ethyl acetate (1L). All organic phases were combined, washed with water (1 L), dried with anhydrous magnesium sulfate, filtered and the organic phase was concentrated under reduced pressure. Finally, 545.76 g of 5-bromo-2-fluoroaniline was obtained in 91% yield by high vacuum treatment for 5 h to completely remove the residual ethyl acetate.

References

[1] Patent: WO2006/48761, 2006, A2. Location in patent: Page/Page column 32
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 19, p. 4337 - 4341
[3] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 44
[4] Patent: WO2004/52847, 2004, A2. Location in patent: Page 171
[5] Patent: CN104530107, 2016, B. Location in patent: Paragraph 0022

364-73-8
2924-09-6
Synthesis of 5-BROMO-2-FLUOROANILINE from 4-Bromo-1-fluoro-2-nitrobenzene
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View Lastest Price from 5-BROMO-2-FLUOROANILINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-BROMO-2-FLUOROANILINE pictures 2025-07-07 5-BROMO-2-FLUOROANILINE
2924-09-6
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
5-BROMO-2-FLUOROANILINE pictures 2025-06-24 5-BROMO-2-FLUOROANILINE
2924-09-6
US $0.00-0.00 / KG 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
5-BROMO-2-FLUOROANILINE pictures 2021-08-12 5-BROMO-2-FLUOROANILINE
2924-09-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
5-BROMO-2-FLUOROANILINE 2-Fluoro-5-Bromoaniline 5-Bromo-2-fluoro Aniline 2924-9-6 5-Bromo-2-fluoroaniline ,98% 5-BROMO-2-FLUOROANIL 1-Amino-5-bromo-2-fluorobenzene 5-Bromo-2-fuoroaniline 5-Bromo-2-fluoroaniline≥ 99% (GC) Benzenamine, 5-bromo-2-fluoro- 5-BROMO-2-FLUOROANILINE ISO 9001:2015 REACH TIANFU-CHEM CAS:2924-09-6 5-BROMO-2-FLUOROANILINE 2,4-di(propan-2-yl)phenol 5-Bromo Aniline 0/6/24 2924-09-6 29424-09-6 374-25-9 2924-09-4 2924-9-6 2924-09-06 374259 C6H6BrCIFN Aniline series Benzenes Phenol&Thiophenol&Mercaptan Anilines, Aromatic Amines and Nitro Compounds