1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL
- CAS No.
- 96960-92-8
- Chemical Name:
- 1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL
- Synonyms
- 1-C16-2-C1 DG;HEXADECYL METHYL GLYCEROL;3-methoxynonadecane-1,2-diol;1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL;1-O-hexadecyl-2-O-Methyl-sn-glycerol (PMG);1-Propanol, 3-(hexadecyloxy)-2-methoxy-, (2S)-;1-O-hexadecyl-2-O-methyl-sn-glycerol (PMG);1-O-Hexadecyl-2-O-methyl-sn-glycerol≥ 98% (HPLC);1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL (PMG);1-C16-2-C1 DG;1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL (PMG);1-C16-2-C1 DG
- CBNumber:
- CB0422354
- Molecular Formula:
- C20H42O3
- Molecular Weight:
- 330.55
- MDL Number:
- MFCD00079347
- MOL File:
- 96960-92-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H350 | |||||||||
| Precautionary statements | P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 60930 | Hexadecyl Methyl Glycerol ≥98% | 96960-92-8 | 10mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 60930 | Hexadecyl Methyl Glycerol ≥98% | 96960-92-8 | 50mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 60930 | Hexadecyl Methyl Glycerol ≥98% | 96960-92-8 | 100mg | $109 | 2024-03-01 | Buy |
| TRC | H290900 | 1-O-Hexadecyl-2-O-methyl-sn-glycerol | 96960-92-8 | 10mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | C5388 | HexadecylMethylGlycerol | 96960-92-8 | 100mg(solution) | $123 | 2021-12-16 | Buy |
1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
Hexadecyl methyl glycerol is a synthetic diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. It inhibits protein kinase C activity in human neutrophils, resulting in prevention of the respiratory burst induced by both phorbol 12,13-dibutyrate and fMLP.
Uses
1-O-Hexadecyl-2-O-methyl-sn-glycerol inhibits protein kinase C activity in human neutrophils.
Definition
ChEBI: 1-O-palmityl-2-O-methyl-sn-glycerol is an alkylglycerol having palmityl (hexadecyl) and methyl groups located at position2 1 and 2 respectively (the S-enantiomer).
Biological Activity
hexadecyl methyl glycerol, also known as amg-c16 with a hexadecyl chain at the sn-1 position, is a novel inhibitor of protein kinase c with ic50 value of about 80 μm [1].protein kinase c is a phospholipid-dependent kinase and the intracellular receptor for phorbol 12-myristate-13-acetate (pma), a substance that activates both the respiratory burst and protein kinase c. pkc enzymes are activated by signals such as increases in the concentration of diacylglycerol (dag) or calcium ions (ca2+) [1].hexadecyl methyl glycerol is a structural analog of diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. hexadecyl methyl glycerol inhibited the activation of purified protein kinase c by diacylglycerol in the presence of phosphatidylserine. in neutrophilic granulocytes, hexadecyl methyl glycerol inhibited the respiratory burst induced by pdbu in a dose-dependent way. in neutrophils, hexadecyl methyl glycerol inhibited the phosphorylation of purified 47-kda protein, an important substrate of protein kinase c [1].
References
[1]. kramer im1, van der bend rl, tool at, et al. 1-o-hexadecyl-2-q-methylglycerol, a novel inhibitor of protein kinase c, inhibits the respiratory burst in human neutrophils. j biol chem. 1989 apr 5;264(10):5876-84.
1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL Preparation Products And Raw materials
Raw materials
Preparation Products
1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Codow Chemical Co.,Ltd. | 18620099427 | amy@howeipharm.com | China | 17698 | 55 |
| Chengdu Dianchun Technology Co., Ltd | 400-1166-196 18502815961 | cdhxsj@163.com | China | 14623 | 60 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 400-400-400-9004166 18616739031 | 3007523370@qq.com | China | 52712 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 55023 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |