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4-Amino-3,5-dichloroacetophenone

CAS No.
37148-48-4
Chemical Name:
4-Amino-3,5-dichloroacetophenone
Synonyms
1-(4-amino-3,5-dichlorophenyl)ethan-1-one;1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone;5-dichlorophenyl)-;TIMTEC-BB SBB003511;3,5-dichloro-4-amino;Clenbuterol EP Impurity C;4-ACETYL-2,6-DICHLOROANILINE;3, 5-dichloro-4-aminophenone;4-Anubi3,5-dichloroacetophenone;4-AMINO-3,5-DICHLOROACETOPHENONE
CBNumber:
CB0423917
Molecular Formula:
C8H7Cl2NO
Molecular Weight:
204.05
MDL Number:
MFCD00238535
MOL File:
37148-48-4.mol
MSDS File:
SDS
Last updated:2024-03-19 17:34:45

4-Amino-3,5-dichloroacetophenone Properties

Melting point 162-166 °C(lit.)
Boiling point 351.5±42.0 °C(Predicted)
Density 1.2748 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka -1.72±0.10(Predicted)
form Solid
color Light Tan to Brown
InChI InChI=1S/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3
InChIKey JLPKZJDZXIKSCP-UHFFFAOYSA-N
SMILES C(=O)(C1=CC(Cl)=C(N)C(Cl)=C1)C
CAS DataBase Reference 37148-48-4(CAS DataBase Reference)
FDA UNII EC3RI6O2DB

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
HS Code  29223990
NFPA 704
0
2 0

4-Amino-3,5-dichloroacetophenone price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 536148 4′-Amino-3′,5′-dichloroacetophenone 97% 37148-48-4 25g $109.2 2024-03-01 Buy
TCI Chemical A1967 4'-Amino-3',5'-dichloroacetophenone >98.0%(GC) 37148-48-4 5g $44 2024-03-01 Buy
TCI Chemical A1967 4'-Amino-3',5'-dichloroacetophenone >98.0%(GC) 37148-48-4 25g $125 2024-03-01 Buy
TRC A604690 1-(4-Amino-3,5-dichlorophenyl)-2-ethanone 37148-48-4 10g $230 2021-12-16 Buy
Biosynth Carbosynth FA17498 1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone 37148-48-4 250g $250 2021-12-16 Buy
Product number Packaging Price Buy
536148 25g $109.2 Buy
A1967 5g $44 Buy
A1967 25g $125 Buy
A604690 10g $230 Buy
FA17498 250g $250 Buy

4-Amino-3,5-dichloroacetophenone Chemical Properties,Uses,Production

Description

 4-Amino-3,5-dichloroacetophenone is an intermediate in the synthesis of the antitussive and antiasthmatic drug gramtin.

Storage

4-Amino-3,5-dichloroacetophenone should be stored in a cool, dry place in a small, well filled, well-closed container, protected from light. When a partially filled container is used, the air should be replaced by nitrogen or another inert gas.
4-Amino-3,5-dichloroacetophenone oxidizes on exposure to air, resulting in an increase in the peroxide value.

Chemical Properties

4-Amino-3,5-dichloroacetophenone is a white to light yellow crystal powder. Insoluble in cold water, slightly soluble in hot water.

Uses

4-Amino-3,5-dichloroacetophenone is used to synthesize the drug Clenbuterol. Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals'lungs.

Application

4-Amino-3,5-dichloroacetophenone is a compound useful in organic synthesis.

Preparation

4-Amino-3,5-dichloroacetophenone was synthesized by chlorination of 4-aminoacetophenone. Add 4-aminoacetophenone and acetic acid (80%) into the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, the temperature of the addition is 5°C. After the addition is completed, immediately put into ice water to precipitate, filter, and wash with water to obtain the crude product. Recrystallize with ethanol to obtain the finished product of 4-Amino-3,5-dichloroacetophenone.

Application

4-Amino-3,5-dichloroacetophenone has active chemical properties and has been widely used in industrial chemistry, agricultural chemistry, and pharmaceutical chemistry. As a selective oxidant and green coupling reagent, it participates in a variety of oxidation reactions, rearrangement reactions, and amination reactions. In industry, it can also be used as a raw material for the synthesis of drugs, disinfectants, dyes, food seasonings, adhesives, explosives, etc.

75-36-5
608-31-1
37148-48-4
Synthesis of 4-Amino-3,5-dichloroacetophenone from Acetyl chloride and 2,6-Dichloroaniline
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View Lastest Price from 4-Amino-3,5-dichloroacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-3,5-dichloroacetophenone pictures 2024-03-19 4-Amino-3,5-dichloroacetophenone
37148-48-4
US $10.00-100.00 / kg 1kg 99% 5000 Metric Ton/Month Wuhan Xinhao Biotechnology Co., Ltd
4-Amino-3,5-dichloroacetophenone pictures 2024-03-19 4-Amino-3,5-dichloroacetophenone
37148-48-4
US $10.00-1.00 / kg 1kg 99% 300tons Hebei Dangtong Import and export Co LTD
4'-Amino-3',5'-dichloroacetophenone pictures 2024-03-19 4'-Amino-3',5'-dichloroacetophenone
37148-48-4
US $0.00 / KG 1KG ≥99% 200mt/year Jinan Finer Chemical Co., Ltd
1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone 5-AMINO-3,5-DICHLORO ACETOPHENONE 4''-AMINO-3'',5''-DICHLOROACETOPHENONECLENBUTEROL 4-Amino-3,5-dichloroacetophenone,98% 4′-Amino-3′,5′-dichloroacetophenone,1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone 3,5-dichloro-p-aMino acetophenone 4-AMino-3,5-dichloroacetophenone, 98% 5GR 4'-AMino-3',5'-dichloroacetophenone SynonyMs 4-Acetyl-2,6-dichloroaniline 4'-Amino-3',5'-dichloroacetophenone 97% TIMTEC-BB SBB003511 1-(4-AMINO-3,5-DICHLOROPHENYL)-ETHANONE 4'-AMINO-3',5'-DICHLOROACETOPHENONE 4-AMINO-3,5-DICHLOROACETOPHENONE 4-ACETYL-2,6-DICHLOROANILINE 3,5-DICHLORO-4-AMINOACETOPHENONE Clenbuterol Impurity 3(Clenbuterol EP Impurity C) Clenbuterol EP Impurity C 4-Anubi3,5-dichloroacetophenone 4-Amino-3,5-dichloroacetophenone CAS: 37148-48-4 CAS 37148-48-4 4-Amino-3,5-dichloroacetophenone High Quality 4-Amino-3, 5-Dichloroacetophenone 4'-Amino-3',5'-dichloroacetophenone > Ethanone, 1-(4-amino-3,5-dichlorophenyl)- Bromo-1-Phenyl-Pentan-1-One 2-Bromovalerophenone Yellow Liquid CAS Pharmaceutical Chemical 2-Bromo-4′-Methylpropiophenone 99% Purity 2-Bromo-1-Phenyl-Pentan-1-One 5-dichlorophenyl)- 3,5-dichloro-4-amino 4-Amino-3,5-dichloroacetophenone Basic information 1-(4-Amino-3,5-dichlorphenyl)ethan-1-on 3, 5-dichloro-4-aminophenone 1-(4-amino-3,5-dichlorophenyl)ethan-1-one 1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone 37148-48-4 H2NC6H2Cl2COCH3 Organic Building Blocks Ketones C7 to C8 Carbonyl Compounds Building Blocks Chemical Amines Amines Aromatics Aromatic Acetophenones & Derivatives (substituted) (intermediate of leflunomide) 37148-48-4