4-Amino-3,5-dichloroacetophenone
- CAS No.
- 37148-48-4
- Chemical Name:
- 4-Amino-3,5-dichloroacetophenone
- Synonyms
- 1-(4-amino-3,5-dichlorophenyl)ethan-1-one;1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone;5-dichlorophenyl)-;TIMTEC-BB SBB003511;3,5-dichloro-4-amino;Clenbuterol EP Impurity C;4-ACETYL-2,6-DICHLOROANILINE;3, 5-dichloro-4-aminophenone;4-Anubi3,5-dichloroacetophenone;4-AMINO-3,5-DICHLOROACETOPHENONE
- CBNumber:
- CB0423917
- Molecular Formula:
- C8H7Cl2NO
- Molecular Weight:
- 204.05
- MDL Number:
- MFCD00238535
- MOL File:
- 37148-48-4.mol
- MSDS File:
- SDS
Melting point | 162-166 °C(lit.) |
---|---|
Boiling point | 351.5±42.0 °C(Predicted) |
Density | 1.2748 (rough estimate) |
refractive index | 1.5500 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | -1.72±0.10(Predicted) |
form | Solid |
color | Light Tan to Brown |
InChI | InChI=1S/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3 |
InChIKey | JLPKZJDZXIKSCP-UHFFFAOYSA-N |
SMILES | C(=O)(C1=CC(Cl)=C(N)C(Cl)=C1)C |
CAS DataBase Reference | 37148-48-4(CAS DataBase Reference) |
FDA UNII | EC3RI6O2DB |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-37/39 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 29223990 | |||||||||
NFPA 704 |
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4-Amino-3,5-dichloroacetophenone price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 536148 | 4′-Amino-3′,5′-dichloroacetophenone 97% | 37148-48-4 | 25g | $109.2 | 2024-03-01 | Buy |
TCI Chemical | A1967 | 4'-Amino-3',5'-dichloroacetophenone >98.0%(GC) | 37148-48-4 | 5g | $44 | 2024-03-01 | Buy |
TCI Chemical | A1967 | 4'-Amino-3',5'-dichloroacetophenone >98.0%(GC) | 37148-48-4 | 25g | $125 | 2024-03-01 | Buy |
TRC | A604690 | 1-(4-Amino-3,5-dichlorophenyl)-2-ethanone | 37148-48-4 | 10g | $230 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA17498 | 1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone | 37148-48-4 | 250g | $250 | 2021-12-16 | Buy |
4-Amino-3,5-dichloroacetophenone Chemical Properties,Uses,Production
Description
4-Amino-3,5-dichloroacetophenone is an intermediate in the synthesis of the antitussive and antiasthmatic drug gramtin.
Storage
4-Amino-3,5-dichloroacetophenone should be stored in a cool, dry place
in a small, well filled, well-closed container, protected from light.
When a partially filled container is used, the air should be replaced by
nitrogen or another inert gas.
4-Amino-3,5-dichloroacetophenone
oxidizes on exposure to air, resulting in an increase in the peroxide
value.
Chemical Properties
4-Amino-3,5-dichloroacetophenone is a white to light yellow crystal powder. Insoluble in cold water, slightly soluble in hot water.
Uses
4-Amino-3,5-dichloroacetophenone is used to synthesize the drug Clenbuterol. Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals'lungs.
Application
4-Amino-3,5-dichloroacetophenone is a compound useful in organic synthesis.
Preparation
4-Amino-3,5-dichloroacetophenone was synthesized by chlorination of 4-aminoacetophenone. Add 4-aminoacetophenone and acetic acid (80%) into the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, the temperature of the addition is 5°C. After the addition is completed, immediately put into ice water to precipitate, filter, and wash with water to obtain the crude product. Recrystallize with ethanol to obtain the finished product of 4-Amino-3,5-dichloroacetophenone.
Application
4-Amino-3,5-dichloroacetophenone has active chemical properties and has been widely used in industrial chemistry, agricultural chemistry, and pharmaceutical chemistry. As a selective oxidant and green coupling reagent, it participates in a variety of oxidation reactions, rearrangement reactions, and amination reactions. In industry, it can also be used as a raw material for the synthesis of drugs, disinfectants, dyes, food seasonings, adhesives, explosives, etc.
4-Amino-3,5-dichloroacetophenone Preparation Products And Raw materials
Raw materials
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Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 | ada@sh-teruiop.com | China | 893 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 | hanson@sdhanjiang.com | China | 1527 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 359 | 58 |
Shijiazhuang Jianxin Biotechnology Co., LTD | +undefined+86-17692708569 | liyingjian1997@gmail.com | China | 787 | 58 |
.GZ HONESTCHEM CO.,LTD | +86-15013270415 | honestchemical@foxmail.com | China | 247 | 58 |
Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 | Ethan@dornechem.com | China | 294 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 436 | 58 |
Related articles
- Synthesis and application of 3,5-dichloro-4-aminoacetophenone
- 3, 5-dichloro-4-aminoacetophenone is an intermediate in the synthesis of the antitussive and antiasthmatic drug gramtin.
- Aug 26,2022
View Lastest Price from 4-Amino-3,5-dichloroacetophenone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-25 | 4-Amino-3,5-dichloroacetophenone
37148-48-4
|
US $10.00 / ASSAYS | 1ASSAYS | 99% | 100kg | Dorne Chemical Technology co. LTD | ||
2024-04-25 | 4'-Amino-3',5'-dichloroacetophenone
37148-48-4
|
US $0.00 / KG | 1KG | ≥99% | 200mt/year | Jinan Finer Chemical Co., Ltd | ||
2024-04-25 | 4-Amino-3,5-dichloroacetophenone
37148-48-4
|
US $0.00 / G | 1G | 99% | 20 | CONTIDE BIOTECH CO.,LTD |
- 4-Amino-3,5-dichloroacetophenone
37148-48-4
- US $10.00 / ASSAYS
- 99%
- Dorne Chemical Technology co. LTD
- 4'-Amino-3',5'-dichloroacetophenone
37148-48-4
- US $0.00 / KG
- ≥99%
- Jinan Finer Chemical Co., Ltd
- 4-Amino-3,5-dichloroacetophenone
37148-48-4
- US $0.00 / G
- 99%
- CONTIDE BIOTECH CO.,LTD
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