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ChemicalBook >> CAS DataBase List >>N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Structure
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine structure
CAS No.
381168-77-0
Chemical Name:
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
Synonyms
ML367;ML-367,ML367,inhibit,ML 367,Inhibitor;N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine;4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
CBNumber:
CB04248334
Molecular Formula:
C19H12F2N4
Molecular Weight:
334.32
MDL Number:
MOL File:
381168-77-0.mol
Last updated:2023-05-21 10:59:17
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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Properties

storage temp. Store at -20°C
solubility DMSO: ≥ 125 mg/mL (373.89 mM)

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Axon Medchem Axon2995 ML367-CID921541 99% 381168-77-0 10mg $137.5 2021-12-16 Buy
American Custom Chemicals Corporation HCH0275430 N-(3,4-DIFLUOROPHENYL)-2-PYRIDIN-4-YLQUINAZOLIN-4-AMINE 95.00% 381168-77-0 5MG $503.57 2021-12-16 Buy
DC Chemicals DC26162 ML367 >98% 381168-77-0 100mg $650 2021-12-16 Buy
DC Chemicals DC26162 ML367 >98% 381168-77-0 1g $2200 2021-12-16 Buy
Product number Packaging Price Buy
Axon2995 10mg $137.5 Buy
HCH0275430 5MG $503.57 Buy
DC26162 100mg $650 Buy
DC26162 1g $2200 Buy

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties,Uses,Production

Biological Activity

ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.

in vitro

ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.

Western Blot Analysis

< table class="zh_use_1"> Cell Line: HEK293T cells Concentration: 0-40 μM in the presence or absence of 20 μM 5-Furd Incubation Time: 16 hours Result: Inhibited the increased ATAD5 protein levels induced by 5-Furd.

target

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Suppliers

Global( 23)Suppliers
TargetValue
ATAD5
()
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4121 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9440 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29797 68
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
DC Chemicals 58

381168-77-0(N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine)Related Search:

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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML367 4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)- ML-367,ML367,inhibit,ML 367,Inhibitor 381168-77-0 C19H12F2N4